DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and Wwc1

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_002727807.1	Gene:	Wwc1 / 303039	RGDID:	1308329	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	107/517 - (20%)
Similarity:	178/517 - (34%)	Gaps:	135/517 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VQSLGGASHTCDRDTVIRKA--ALERQKRNELRQKENGAVVLQSYARSFIHRQRRKRAEREVF-- 73
            |..:.|:|.:...|..|.||  |..:.:.|:|:             |..:|.|...:.:...|
  Rat   143 VSLVSGSSSSSKYDPEILKAEIATAKSRVNKLK-------------REMVHLQHELQFKERGFQT 194

  Fly    74 ----DIYLMGHKDGIVEDESLTFLLRRLNFFYSIREAKDSERLIEVC-----QQILRQPARL--- 126
                |..:...:.|...||:...|          ||.|..::.| .|     |.:::..|.|
  Rat   195 LKKIDERMSDAQGGYKLDEAQAVL----------RETKAIKKAI-TCGEKEKQDLIKSLAMLKDG 248

  Fly   127 --LQHSSPDSLWLLRLCKLLDTCLLQLSLSHTAQAIPLRMLE---------TFTTVSSVQQYMKD 180
              ....|...||           ....||..::..:|.:.|:         :|:| ||..|..:.
  Rat   249 FRTDRGSHSDLW-----------SSSSSLESSSFPVPKQFLDVSSQTDISGSFST-SSSNQLAEK 301

  Fly   181 EAVLFQYME---RVFGFLIARNYFVRLRRLLDDKCP-PLDGETLHAPSPLAEALLQL-----LLR 236
            ..:..:|.|   |:      .|..::|.:|..:..| .||.|        .:.|:.:     ||:
  Rat   302 VRLRLRYEEAKRRI------ANLKIQLAKLDSEAWPGVLDSE--------RDRLILINEKEELLK 352

  Fly   237 PLE-VAKRASAGGQMSSMSMAVCRNFTRDILATPHTDPLRYFVLPCFALNVDFPFDLLMRSLYDA 300
            .:. ::.|....|::..:.|| .|...:|:.|...|.....    ...|.::...:.|:|.|.:|
  Rat   353 EMRFISPRKWTQGEVEQLEMA-RRRLEKDLQAARDTQSKAL----TERLKLNSKRNQLVRELEEA 412

  Fly   301 LESAGPAESD--STSSRRSFLFYGVETGHKTTRMDSIFSSFLLNSLMVLDRRQLATLHQSPLLVI 363
            ........|.  |.||....|..|...|..|:...|:.:|.|.:|...    ....|:..|
  Rat   413 TRQVAALHSQLKSLSSSMQSLSSGSSPGSLTSSRGSLAASSLDSSTSA----SFTDLYYDP---- 469

  Fly   364 YVRLIAEMMPNI--LQLPKST-LRGHANAPHRHRDGDDDSEESEDEDEELPAARTLDYDMEQTCR 425
            :.:|.:|:...:  |.|..:| .|........|.|....::::|. ...|.|.|:|    ..|.|
  Rat   470 FEQLDSELPSKVELLFLEGATGFRPSGCITTIHEDEVAKTQKAEG-GSRLQALRSL----SGTPR 529

  Fly   426 TSGELSVKE-------------RECLLESIAILNETERVDFIVQQLDPHIENTHLIYALCEI 474
            :...||.:.             .:.||...|.|...|            .|:|.|...|||:
  Rat   530 SMTSLSPRSSLSSPSPPCSPLIADPLLAGDAFLTPLE------------FEDTELSPTLCEL 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523
Wwc1	XP_002727807.1	WW	9..39	CDD:238122
		WW	55..84	CDD:278809
		ALDH-SF	378..>420	CDD:299846	8/45 (18%)
		C2_Kibra	661..784	CDD:176062
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900