DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG3356 and Arel1

DIOPT Version :9

Sequence 1:NP_611896.1 Gene:CG3356 / 37876 FlyBaseID:FBgn0034989 Length:1122 Species:Drosophila melanogaster
Sequence 2:NP_001100214.1 Gene:Arel1 / 299197 RGDID:1307597 Length:823 Species:Rattus norvegicus


Alignment Length:637 Identity:174/637 - (27%)
Similarity:266/637 - (41%) Gaps:121/637 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   547 CMLFGRLLPTLHDVEFVENKLLLQVHSTINHVRLMPFSIAE--IIQMSKTLKDI-----SMGLVE 604
            |.:|.||  |||....        .|:.|:: :..|.:..|  ||.:|:..|:|     |...|.
  Rat   241 CQVFLRL--TLHSRGC--------FHACISY-QNQPINNGEFDIIVLSENEKNIVERNVSTSGVS 294

  Fly   605 LAFPETRSNLANYRKVLGH------------------TEADD--------KKLRHQKQIWANL-- 641
            :.|.....|..:|.....|                  .|.:|        :|::..|:::..:  
  Rat   295 IYFEAYLYNANSYSSAPWHLPPMHMSSSQRRPSTALEEEEEDSPSECHTPEKVKKPKKVYCYVSP 359

  Fly   642 --LNVVVFVLNQIHTRDLRLGFCPEDHWTVTRLDLPLDRPTDLPLTHSSRLRGIRPFQPIRDFTR 704
              .:|..|.|..|..|......||...::....| |:.:...|.:..     ||:|  |:....:
  Rat   360 KQFSVKEFYLKIIPWRLYTFRVCPGTKFSYLGPD-PVHKLLTLVVDD-----GIQP--PVELSCK 416

  Fly   705 EDFENGPPMSTKQIRSITILREIPFVV----PFNKRVSILQSLVAASKMRVQGNMQAFLQGP--S 763
            |          :.|.:.|.:|.:...:    .|..:|:..|     .::|     |..::.|  .
  Rat   417 E----------RNILAATFIRSLHKNIGGSETFQDKVNFFQ-----RELR-----QVHMKRPHSK 461

  Fly   764 VLITVRRSHLYEDAYDKLRPDNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDP 828
            |.:.|.|..|.|.:....|..:..|....|.:.|     .||..:|.||..||:...:.|..||.
  Rat   462 VTLKVSRHALLESSLKATRNFSISDWSKNFEVVF-----QDEEALDWGGPRREWFELICKALFDT 521

  Fly   829 NRGFFMVTTDNK---LYPNPN-VADLFEDYEKHYYFIGRILGKSIYENLL----VELPLAEF--- 882
            ....|...:||.   ::|||| .|.|   ..|.|.|.||::||.:||:.|    .:|..|.|   
  Rat   522 TSQLFTRFSDNNQALVHPNPNRPAHL---RLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRS 583

  Fly   883 FLTKLAG-----KYSDVDIHQLASLDPELYRN-LLYLKDYSGDVSELNLDFTVAS-SSLGQ-TQI 939
            ||.::.|     ||.:.|       |||.|:: :.::  .:.|:||:.|.|.... :..|| .:|
  Rat   584 FLAQIIGLRMHYKYFETD-------DPEFYKSKVCFI--LNNDMSEMELVFAEEKYNKSGQLDKI 639

  Fly   940 VELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILI 1004
            |||...|...||||:|:..||.|:|.|:|..|::.....|.|||:.::|...|.:|...||::|:
  Rat   640 VELMTGGAQTPVTNANKTFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLM 704

  Fly  1005 SGAEIPIDLEDLKKHC-EYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKD 1068
            .|.. .|.:.|.|.|. ..||.:......:..||.|:......:..:||:|.|..|:.|..||..
  Rat   705 CGTG-DISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAA 768

  Fly  1069 LDPPFFIQNTGDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGA-GF 1119
            |.|.|.|........||||.||.|.|.||.:.:.|::...|..||..|. ||
  Rat   769 LCPSFQIIAAPTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG3356NP_611896.1 HECTc 766..1120 CDD:238033 123/375 (33%)
HECTc 788..1119 CDD:214523 116/351 (33%)
Arel1NP_001100214.1 Filamin 56..154 CDD:395505
HECTc 486..820 CDD:214523 116/351 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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