DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and Nedd4l

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_038952600.1	Gene:	Nedd4l / 291553	RGDID:	735047	Length:	1259	Species:	Rattus norvegicus

Alignment Length:	499	Identity:	151/499 - (30%)
Similarity:	247/499 - (49%)	Gaps:	68/499 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   665 DH------WTVTRLDLPLD-------RPTDL-PL-----------------THSSRL----RGIR 694
            ||      |...||..|:.       .|.|| ||                 .|||::    ...|
  Rat   783 DHNTKTTTWEDPRLKFPVHMRSKASLNPNDLGPLPPGWEERIHLDGRTFYIDHSSQVLCGENDTR 847

  Fly   695 PFQPIRDFTREDFENGPPMSTKQIRSITILREIPFVVPFNKRVSILQSLVAASKMRVQGNMQAFL 759
            ...|:.|.....:|: |.:....|..    ..:|:...|.::....:     .|::...::....
  Rat   848 ESVPLYDSKITQWED-PRLQNPAITG----PAVPYSREFKQKYDYFR-----KKLKKPADIPNRF 902

  Fly   760 QGPSVLITVRRSHLYEDAYDKLRPDNEPD-LRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIK 823
            :     :.:.|::::|::|.::.....|| |:.:..|:|.|     |.|:|.|||.||:...|.|
  Rat   903 E-----MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFES-----EKGLDYGGVAREWFFLLSK 957

  Fly   824 TAFDPNRGFFMVT-TDN-KLYPNPNVADLFEDYEKHYYFIGRILGKSIYENLLVELPLAEFFLTK 886
            ..|:|..|.|..: ||| .|..|||.....||:..::.||||:.|.:::...|::......|...
  Rat   958 EMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKM 1022

  Fly   887 LAGKYSDVDIHQLASLDPELYRNLLYLKDYSGDVSELNLDFTVASSSLGQTQIVELKPQGQSIPV 951
            :.||  .:.::.:.|:|.|.|.:|.::.:  .|.:||:|.|.:...:.|||..|:|||.|..|.|
  Rat  1023 MLGK--QITLNDMESVDSEYYNSLKWILE--NDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMV 1083

  Fly   952 TNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDL 1016
            ||.|:.||:.|:..::...::::..|||.:|.:.:|||:.:.:|...||::|:.|.. .:|:.|.
  Rat  1084 TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG-DVDVNDW 1147

  Fly  1017 KKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDL----DPPFF-IQ 1076
            ::|..|...:.|.||.|..||:.:...|..:|.:||:|||..||.|:.||.:|    .|..| |:
  Rat  1148 RQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIE 1212

  Fly  1077 NTGDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGFE 1120
            ..|..|:||.|.||.|.|.|||::|.|.:|||||.|:::..|||
  Rat  1213 QWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 1256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	126/361 (35%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	121/338 (36%)
Nedd4l	XP_038952600.1	C2	<365..418	CDD:417471
		WW	463..489	CDD:395320
		WW	653..682	CDD:395320
		WW	766..796	CDD:238122	3/12 (25%)
		WW	815..865	CDD:197736	10/50 (20%)
		HECTc	926..1255	CDD:214523	121/338 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810