DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and Hecw1

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_017455974.1	Gene:	Hecw1 / 291209	RGDID:	1561038	Length:	1603	Species:	Rattus norvegicus

Alignment Length:	996	Identity:	227/996 - (22%)
Similarity:	380/996 - (38%)	Gaps:	233/996 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 PPLDGETLHAPSPLAEALLQLLLRPLEVAKRASAGGQMSSMSMAVCRNFTRDILATPHTDPLRYF 277
            |.||.|:.:...|..:.|             |:.||..:.         |.:.|.:|...|....
  Rat   753 PELDPESTNGAGPWQDEL-------------AAPGGNAAR---------TTEGLDSPMAGPSNRR 795

  Fly   278 VLPCFALNVDFPFDLLMRSL------YDALESAGPAESDSTSSRRSFLFYGVETGHKTTRM---- 332
            ...|..|:...|...| .||      |..::...|...::.......:|| |:..::||..
  Rat   796 EGDCPMLHNSQPISQL-PSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFY-VDHVNRTTTWQRPS 858

  Fly   333 -----DSIFSSFLLNSLMVLDRRQLATLHQSPLLVIYVRLIAEMMPN--ILQLPKSTLRGHANAP 390
                 |.:..|..::.:..|:||     :|:....|......|...|  ..|:|.....|
  Rat   859 MAPTPDGMIRSGSVHQMEQLNRR-----YQNIQRTIATERSEEDSGNQSCEQIPDGGAGG----- 913

  Fly   391 HRHRDGDDDSEESEDEDEELPAARTLDYDMEQTCRTSGELSVKERECLLESIAILNETERVDFIV 455
                .|.|...||...:.:|              |..|.||....    :.:.:|.::..|.||.
  Rat   914 ----GGSDSEAESSQSNLDL--------------RREGSLSPVNS----QKVTLLLQSPAVKFIT 956

  Fly   456 QQLDPHIENT-HLIYALCEICHNLMIYNKHAVFEYKLLYTLAFTPKFIR------AVWFKLAAES 513
               :|..... |..|:.      ..::......::.:|........|.|      .|.|......
  Rat   957 ---NPEFFTVLHANYSA------YRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFAD 1012

  Fly   514 TQLGFSAPLTLISKG--VVPKHQG----VDRTIPLLATFCMLFGRLLPTLHD---VEFVENKLLL 569
            |:|.       :.:|  :...|||    ||                    |:   ..|::.::.|
  Rat  1013 TRLE-------LPRGWEIKTDHQGKSFFVD--------------------HNSRATTFIDPRIPL 1050

  Fly   570 QVHSTINHV-------RLMPFSIAEIIQMSKTLKDISMGLVELAFPETRSNLANYRKVLGHTEAD 627
            |.....||:       ||..:|..|..::|:     :.|...||.|             ||:...
  Rat  1051 QNGRLPNHLTHRQHLQRLRSYSAGEASEVSR-----NRGASLLARP-------------GHSLIA 1097

  Fly   628 DKKLRHQKQIWANLLN--VVVFV---------------LNQIHTRDLRLGFCPEDHWTVTRLDLP 675
            ..:.:||.:......|  :|.|:               |.:.||...::      |:..|..:..
  Rat  1098 AIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKI------HYIRTEGNHG 1156

  Fly   676 LDR---PTDLPLTHSSRLRGIRPFQPIRDFTREDFENGP-------PMSTKQIRSITILREIPFV 730
            |::   ..||.:..|.....|..:.|::......:...|       |.::..::..:.....|:.
  Rat  1157 LEKLSCDADLVILLSLFEEEIMSYVPLQSAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYR 1221

  Fly   731 VPFNKRVSILQSLVAASKMRVQGNMQAFLQGP-SVLITVRRSHLYEDAYDKLRPDNEPDL-RFKF 793
            ..|..::....     .|:..:|    |.||| .:.:.:||.||.|..::::...:..:| |.|.
  Rat  1222 RDFEAKLRNFY-----RKLEAKG----FGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKL 1277

  Fly   794 RIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDN----KLYPNPNVADLFEDY 854
            .|.||.     |.|:|..|..|||...|.:..|:|..|.|..:.::    ::.|   ::...|:|
  Rat  1278 YITFVG-----EEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISP---MSAFVENY 1334

  Fly   855 EKHYYFIGRILGKSIYENLLVELPLAEFF-------LTKLAGKYSDVDIHQLASLDPELYRNLLY 912
            .:.:.|.|||||.::....|::    .||       |.||     ..|:..|..||.|.:::|.:
  Rat  1335 LEWFRFSGRILGLALIHQYLLD----AFFTRPFYKGLLKL-----PCDLSDLEYLDEEFHQSLQW 1390

  Fly   913 LKDYSGDVSE-LNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHC 976
            :||  .:::: |:|.|||.....||....|||..|.:..||..|:.||::.:..:::...:.:..
  Rat  1391 MKD--NNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQT 1453

  Fly   977 NAFRKGLSNVLPIEWLYMFSNKELQILISG-AEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVL 1040
            .|..:|...|:....:.:|..:||:::|:| ||  |||.|.:.:.||.|.:...|..|..||..:
  Rat  1454 EALVRGFYEVVDSRLVSVFDARELELVIAGTAE--IDLNDWRNNTEYRGGYHDGHLVIRWFWAAV 1516

  Fly  1041 EGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPP-----FFIQNTGDMERLPTASTCTNLLKLPPFK 1100
            |.|::.||.:||:|||..|..|..||..|...     |.|:..|.:..||.|.||.|.|.|||:.
  Rat  1517 ERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYP 1581

  Fly  1101 TVEQMREKLLYAIQSGAGFEL 1121
            :...:.||||.|::..:.|.|
  Rat  1582 SYSTLYEKLLTAVEETSTFGL 1602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	115/372 (31%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	110/349 (32%)
Hecw1	XP_017455974.1	HECW_N	66..185	CDD:293170
		C2_NEDL1-like	206..342	CDD:176073
		WW	827..857	CDD:197736	6/30 (20%)
		WW	1017..1048	CDD:197736	8/50 (16%)
		HECTc	1247..1601	CDD:238033	115/374 (31%)
		HECTc	1271..1600	CDD:214523	110/349 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810