DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and HERC4

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_011537894.1	Gene:	HERC4 / 26091	HGNCID:	24521	Length:	1081	Species:	Homo sapiens

Alignment Length:	668	Identity:	178/668 - (26%)
Similarity:	287/668 - (42%)	Gaps:	113/668 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   507 FKLAAESTQLGFSAPLTLISKGVVPKHQGVDRTIPLLATFCMLFGRLLP----TLHDVEFVENKL 567
            ::.....:.:..:|...|..|.:.|.|..:.:.:.     ..|...|:|    :|.|||
Human   473 YRTGTRFSGVDMNAARLLFHKLIQPDHPQISQQVA-----ASLEKNLIPKLTSSLPDVE------ 526

  Fly   568 LLQVHSTINHVRLM-----------PFSIAEIIQMSKT-LK-----------DISMGLVELAFPE 609
            .|:.:.|:....||           ||..| ::.:.|. ||           .:.:.:||| |.|
Human   527 ALRFYLTLPECPLMSDSNNFTTIAIPFGTA-LVNLEKAPLKVLENWWSVLEPPLFLKIVEL-FKE 589

  Fly   610 TRSNLANYRKVLGHTEADDKKLRHQKQIWANLLNVVVFVLNQIHTRDLRLG-FCPEDHWTVTRLD 673
            ...:|....|: |...:       :::|:.:.|:..:.||..:|..:.::| ....|.:.:..:.
Human   590 VVVHLLKLYKI-GIPPS-------ERRIFNSFLHTALKVLEILHRVNEKMGQIIQYDKFYIHEVQ 646

  Fly   674 LPLDRPTDLPLTHSSRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILREIPFVV---PF-- 733
            ..:|...|.......:..|:            |..:|          :|.|.:||..:   ||
Human   647 ELIDIRNDYINWVQQQAYGM------------DVNHG----------LTELADIPVTICTYPFVF 689

  Fly   734 --------NKRVSILQSLVAASKMRVQGNMQAFLQ-----GPSVLITVRRSHLYEDAYDKLRPDN 785
                    .:..::||..:|..:...|.....||.     .|.:::.|||.::..||.:.||...
Human   690 DAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTK 754

  Fly   786 EPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKL--YPNPNVA 848
            ..|.:...::.||.     |..:|.|||.:||...:::...||..|.|....|::|  :.:..
Human   755 NIDYKKPLKVIFVG-----EDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKT-- 812

  Fly   849 DLFEDYEKHYYFIGRILGKSIYENLLVEL--PLAEFFLTKLAGKYSDVDIHQLASLDPELYRNLL 911
              |||.:. ::.||.|.|.:||...:|:|  |||.:  .||..|...:|  .|..|.|::.|::.
Human   813 --FEDSDL-FHLIGVICGLAIYNCTIVDLHFPLALY--KKLLKKKPSLD--DLKELMPDVGRSMQ 870

  Fly   912 YLKDY-SGDVSE-LNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRR 974
            .|.|| ..|:.| ..|:||:...:.|.|::.||...|....|...||.|::....||..|..:..
Human   871 QLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVAS 935

  Fly   975 HCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEV 1039
            ..:||..|...|...:.|.:|...|||.::.| ....|.::|:|:.||.||:..|||:|..||||
Human   936 LFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG-NTNYDWKELEKNTEYKGEYWAEHPTIKIFWEV 999

  Fly  1040 LEGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPPFFIQNTGDMER-LPTASTCTNLLKLPPFKTVE 1103
            .......:::|.|.|:|...|.|:||.|.|  ...||:||..|. ||.:.||.|||.||.:...|
Human  1000 FHELPLEKKKQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKE 1062

  Fly  1104 QMREKLLYAIQSGAGFEL 1121
            .:|.||:.||....||.|
Human  1063 TLRSKLIQAIDHNEGFSL 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	121/360 (34%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	113/337 (34%)
HERC4	XP_011537894.1	RCC1	2..368	CDD:332518
HERC4	XP_011537894.1	HECTc	733..1079	CDD:238033	121/362 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810