Protein Alignment CG3356 and MAGI3

DIOPT Version :9

• Sequence 1: NP_611896.1
• Gene: CG3356 / 37876
• FlyBaseID: FBgn0034989
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: NP_001136254.1
• Gene: MAGI3 / 260425
• HGNCID: 29647
• Length: 1481
• Species: Homo sapiens
• Alignment Length: 391
• Identity: 77/391 - (19%)
• Similarity: 140/391 - (35%)
• Gaps: 117/391 - (29%)

  Fly   629 KKLRHQKQIWANLLNV----VVFVLNQIHT-RDLRL----GFCP-------------EDHWTVTR 671
            |::.||     |:.|:    ||.||.|... .|:.|    |..|             |:..::..
Human   620 KEIYHQ-----NVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEA 679

  Fly   672 LDLPLDRPTDLPLTHSSRLRGIRP-FQPIRDFTRED--FENGPPMSTKQIRSITILREIPF---- 729
            ::.|:.:|...|   .|.:|...| ..|...:.:..  :|:.|| :||.:......:|..|
Human   680 INEPIPQPMPFP---PSIIRSGSPKLDPSEVYLKSKTLYEDKPP-NTKDLDVFLRKQESGFGFRV 740

  Fly   730 --------------VVPF-----NKRVSILQSLVAASKMRVQGN--------MQAFLQGPSVLIT 767
                          ::|.     :.|:.....|:....:.|:|.        |....:...||:|
Human   741 LGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLT 805

  Fly   768 VRRSHLYEDAYDKLRPDNEPDLRFKFRIQFVS----SLGLDEAGIDGGGVFREFLSELIKTAFDP 828
            |||...|.:.    :|:::...      .|:|    |..|:.|.:......:|....:::...:.
Human   806 VRRKIFYGEK----QPEDDSSQ------AFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENE 860

  Fly   829 NRGFFMVTTDNKLYPNPNVADLFEDYEKHYYFIGRILGKSIYENLLVELPLAEFFLTKLAGKYSD 893
            ..||.::|:.||  |.|.|..         :.|||::..|         |.......|:....|.
Human   861 GFGFVILTSKNK--PPPGVIP---------HKIGRVIEGS---------PADRCGKLKVGDHISA 905

  Fly   894 VDIHQLASLDPELYRNLLYLKDYSGDVSELNLDFTV-----------ASSSLGQTQIVELKPQGQ 947
            |:...:..|.   :.|::.|...:|    :.:..||           .::|..|:..::.:|.||
Human   906 VNGQSIVELS---HDNIVQLIKDAG----VTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQ 963

  Fly   948 S 948
            |
Human   964 S 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	40/198 (20%)
		HECTc	788..1119	CDD:214523	34/176 (19%)
MAGI3	NP_001136254.1	Interaction with ADRB1 and TGFA. /evidence=ECO:0000250	18..106
		PDZ_signaling	24..101	CDD:238492
		NK	123..>197	CDD:327404
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..273
		WW	294..326	CDD:197736
		WW	342..372	CDD:238122
		Interaction with PTEN. /evidence=ECO:0000269|PubMed:10748157	410..492
		PDZ	413..493	CDD:214570
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..570
		PDZ	575..656	CDD:214570	12/40 (30%)
		Interaction with ADGRB1. /evidence=ECO:0000269|PubMed:10748157	726..808		12/81 (15%)
		PDZ_signaling	726..807	CDD:238492	11/80 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	821..843		5/27 (19%)
		PDZ_signaling	849..935	CDD:238492	21/112 (19%)
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000269|PubMed:10748157, ECO:0000269|PubMed:16904289	851..938		22/113 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	939..976		6/26 (23%)
		PDZ_signaling	1022..1100	CDD:238492
		Red1	<1132..1461	CDD:311769
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1170..1481

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900