DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and SPAC167.07c

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_593378.1	Gene:	SPAC167.07c / 2542770	PomBaseID:	SPAC167.07c	Length:	1029	Species:	Schizosaccharomyces pombe

Alignment Length:	1205	Identity:	322/1205 - (26%)
Similarity:	512/1205 - (42%)	Gaps:	266/1205 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FDGEYRRRPVQSLGGASHTCDRDTVIRKAALERQKRNELRQKENGAVVLQSYARSFIHRQRRKRA 68
            |:|.::.:...:|||...:.||..::||||:||:.|.|.|:.||.:|.:||.:|.|:.|::.|:.
pombe     5 FEGTFKAKRNVNLGGKRVSNDRAQLLRKAAMERKNREEERKAENNSVAVQSLSRGFLARRKFKQD 69

  Fly    69 EREVFDIYLMGHKDGIVEDESLTFLLRRLNFFYSIREAKDSERLI--------------EVCQQI 119
            .||.: ||.. .|.|           |....|.::.:.|.|..|:              :|...|
pombe    70 FRERW-IYKY-TKSG-----------RTSIRFNTLEDIKCSISLLVLFAEPDIDLPFVSQVAHNI 121

  Fly   120 L-------------------------RQPARLLQHSSPDSLWLLRLCKLLDTCLLQLSLSHTAQA 159
            |                         .:....|.:|:...|| .|...||..||:....||
pombe   122 LVWLENLIPLSNGMDDTPKSHLKVKILKVQETLSNSNDSWLW-QRFSSLLLNCLVSSINSH---- 181

  Fly   160 IPLRMLETFTTVSS--------VQQYMKDEAVLFQYMERVFGFLIARNYFVRLRRLLDDKCPPLD 216
               |:..|.|:..:        |..|:| .:.|..|.:.|..| .|:.|             |..
pombe   182 ---RIEGTDTSAETSLLHCLAYVAPYLK-SSELSTYYDSVMTF-YAQIY-------------PKQ 228

  Fly   217 GETLHAPSPLAEALLQLLLRPLEVAKRASAGGQMSSMSMAVCRNFTRDILATPHTDPLRYFVLPC 281
            ..|     .|.:.:...||.|  |:.:.......||.       |...:||:           .|
pombe   229 NMT-----NLEDIMSLSLLTP--VSSKTDENANSSSA-------FLFHVLAS-----------DC 268

  Fly   282 F-ALNVDFPFDLLMRSLYDALESAGPAESDSTSSR------RSFLFYG-----VETGHKTTRMDS 334
            | ::....|.||::..::.:  |...:|....||.      :.|...|     :.|.:|.:.:..
pombe   269 FSSIENCIPPDLIIDKVFSS--SLQLSEEACISSLLNLGMIKVFSLAGNCLHLLHTEYKNSSLWK 331

  Fly   335 IFSSFLLNSLMVLDRRQLATLHQSPLLVIYVRLIAEMMPNILQLPKSTLRGHANAPHRHRDGDDD 399
             |.|::|::|.|.....:.:         .:::::::                       |.|:|
pombe   332 -FCSYILDALYVFSGESVNS---------RIQVVSDV-----------------------DDDED 363

  Fly   400 SEESEDEDEELPAARTLDYDMEQTCRTSGELSVKERECLLESIAILNETERVDFIVQQLDPHIEN 464
            .|.:..::..........:..:.....||.:.....|| :.|..|....:.|.....|...|...
pombe   364 DENAFSQNYYSHLQMVAKHFSKNYANQSGIVQRSFAEC-ISSTFITKAFKLVSSNTLQAMSHFYA 427

  Fly   465 THLIYALCEICHNLMIYNKHAVFEYKLLYTL---AFTPKFIRAVWFKLAAESTQLGFSAPLTLIS 526
            |.:         .|...|:.::..|..|...   :.|..|.|..|...:.......|.....:
pombe   428 TMI---------KLFPSNRTSILMYISLVETNEGSLTRSFSRFSWDMFSESPVYQLFHKKFDV-- 481

  Fly   527 KGVVPKHQGVDRTIPLLATFCMLFGRLLPTLHDVEFVENKLLLQVHSTINHVRLMPFSIAEIIQM 591
            :.|:....|....:.||..   ::.|:|.|:.|.||..:|          ...|.|.    :.:.
pombe   482 QNVLKNDSGYWFQLQLLID---VYSRMLFTMIDDEFHNDK----------QNPLYPV----MAEF 529

  Fly   592 SKTLKDISMGLVELAFPETRSNLANYRKVLGHTEADDKKLRHQKQIWANLLNVVVFVLNQIHTRD 656
            ...||::.:||              |..|....:.|.|.:....|:..:..:    :|.|::..:
pombe   530 CTVLKNLVLGL--------------YWDVQAAKDVDCKSVVDISQLRVSSTS----LLQQLYRIN 576

  Fly   657 LRLGFCPEDHWTVTRL--------------DLPLDRPTDLPLTHSSRLRGIRPFQPIRDFTREDF 707
            .|..|.|||.:.::..              :|......::.:|:..                ::|
pombe   577 SRKQFLPEDFFLMSEYFNLNEFEANALQESELASHAEAEINITYKF----------------DNF 625

  Fly   708 ENGPPMSTKQIRSITILREIPFVVPFNKRVSILQSLVAASKMRVQGNMQAFLQGPSVLITVRRSH 772
            ....|       .:.||....|.:||:.|:.:||.|:...| :..|..|.|  |......:||:.
pombe   626 SESRP-------RLNILNNCSFFLPFHFRIHLLQQLLLLDK-QANGYAQPF--GHLKHAVIRRNR 680

  Fly   773 LYEDAYD------KLRPDNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRG 831
            :::|.:|      ||       |:...||.||...|:.|.||||||:.:|||:.:.||.||.|.|
pombe   681 IFDDGFDAFYNFGKL-------LKGPIRITFVDEHGVVEEGIDGGGLTKEFLTSICKTVFDINYG 738

  Fly   832 FFMVTTDNKLYPNPNVADLFEDYE--KHYYFIGRILGKSIYENLLVELPLAEFFLTKLAGKYSDV 894
            .|..|..:.||||.:.  ..:|.|  :.|.|:|.::||.|||.:.::...|.||:.|..|..|..
pombe   739 LFSETKAHLLYPNTHA--YAQDVERLRCYEFLGMLIGKCIYEGIQIDAAFASFFVAKWLGHPSYF 801

  Fly   895 DIHQLASLDPELYRNLLYLKDYSGDV-SELNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIE 958
            |  .|.||||.||..|::||:|.||| :::.|:|||.....|...:::|.|.|.:|.|||.||::
pombe   802 D--DLTSLDPNLYEGLVFLKNYDGDVENDMALNFTVVHEEFGVRNVIDLIPNGSNISVTNENRLQ 864

  Fly   959 YLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLKKHCEYG 1023
            |:.|:::|.||.::.|.|.||..|.:.::...||.||...|:|||:.|..:|||::||::|..|.
pombe   865 YIHLVSNYYLNARLSRQCRAFTNGFTQIIDPHWLAMFHESEIQILVGGDPVPIDIDDLRRHTVYA 929

  Fly  1024 GEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPPFFIQNTGDME-RLPTA 1087
            |.:.|..|:||.|||||..|::..:|..:|||||.:|||:||||.|.|.|.|:..|:.| |||||
pombe   930 GGYEPNSPTIVLFWEVLREFEEEDKRSFVKFVTSVARPPILGFKALMPSFCIRVNGEDETRLPTA 994

  Fly  1088 STCTNLLKLPPFKTVEQMREKLLYAIQSGAGFELS 1122
            |||.||||||.:.|.:.:|:|||.|::||.||..|
pombe   995 STCVNLLKLPMYSTKQTLRDKLLTAVRSGVGFGFS 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	158/363 (44%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	151/334 (45%)
SPAC167.07c	NP_593378.1	HUL4	155..1029	CDD:227354	281/1040 (27%)
SPAC167.07c	NP_593378.1	HECTc	676..1027	CDD:238033	158/361 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	273	1.000	Domainoid score	I324
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	375	1.000	Inparanoid score	I432
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005112
OrthoInspector	1	1.000	-	-		oto101739
orthoMCL	1	0.900	-	-		OOG6_100865
Panther	1	1.100	-	-	LDO	PTHR45700
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1831
SonicParanoid	1	1.000	-	-		X3631
TreeFam	1	0.960	-	-
	12	11.850