DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and Plekha5

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_647556.1	Gene:	Plekha5 / 246237	RGDID:	621175	Length:	1281	Species:	Rattus norvegicus

Alignment Length:	984	Identity:	166/984 - (16%)
Similarity:	318/984 - (32%)	Gaps:	303/984 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FGFDGEYRRRPVQSLGGASHTCDRDTVIRKAALERQKRNELRQKENGAVVLQSYARSFIHRQRR- 65
            :....:|...|:..:|..|...      :|.....::.|.:::..|..||    .|.::::|..
  Rat   129 YNMASDYTVHPMSPVGRTSRAS------KKVHNFGKRSNSIKRNPNAPVV----RRGWLYKQDST 183

  Fly    66 -----KRAEREVFDIYLMGHKD----GIVEDESL-TFLLRRL------NFFYSIREAKDSERLIE 114
                 |:....:.|:.|..::|    ||:....| :|.:..|      |..|:.:.|..:.|...
  Rat   184 GMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIAMLTAEDHINRKYAFKAAHPNMRTYY 248

  Fly   115 VCQQILRQPARLLQHSSPDSLWLLRLCKLLDTCLLQLSLSHTAQAIPLRML------ETFTTVSS 173
            .|....::.          .||:.   .:||..|:|..        |::.:      :..||.|:
  Rat   249 FCTDTGKEM----------ELWMK---AMLDAALVQTE--------PVKRITFNFRVDKITTESA 292

  Fly   174 ------------------VQQYMKDEAVLFQYMERV-----FGFL-------IARNYFVRLRRLL 208
                              ||...|::.:.....:|.     :||.       :.:...|:|..|.
  Rat   293 STKETNNIPNHRVLIRPEVQNNQKNKEISKIEEKRALEAERYGFQKDGQDRPLTKINSVKLNSLP 357

  Fly   209 DD-----KCPPLDGETLHAPSPLAEALLQLLLRPLEVAKRASAGGQMSSMSMAVCRNFTRDILAT 268
            .:     .|||   :.:|             .||:.|   .::..:..::|:|..|..:.
  Rat   358 SEYESGPACPP---QNIH-------------YRPINV---NNSDSKAVNVSLADVRGGSH----- 398

  Fly   269 PHTDPLRYFVLPCFALNVD-------------------------------FPFDLLMRSL----- 297
            |:|.||        |...|                               ..:..|.|::
  Rat   399 PNTGPL--------ATEADRVIQRTNSMQQLEQWIKVQKGRGLEEEPRGVISYQTLPRNMPSHRA 455

  Fly   298 ---------YDALESAGPAESDS----TSSRRSFLFYGVETGHKTTRMDSIFSSF---------- 339
                     |..|........:|    |.|.......|.|...::.|.|:::..:
  Rat   456 QILARYPEGYRTLPRNSKTRPESICSVTPSGHEKTGPGAEEKRRSMRDDTMWQLYEWQQRQFYHK 520

  Fly   340 --------LLNSLMVLDRRQLATLHQSPLLVIYVRLIAEMMPNILQLPKSTLRGHANAP------ 390
                    .|:|...:.:....|:|..|....:|...|....:    |:.|.|...::|
  Rat   521 QSTLPRHSCLSSPKAMGKVSDQTMHSIPTSPSHVPAAAYQGFS----PQRTYRSEVSSPIQRGDV 581

  Fly   391 ---HRHRDGDDDSEESEDEDEELPAARTLDYDMEQTC--RTSGELS-----VKERECLLESIAIL 445
               .|||..........|. ..:||...|.....|:.  ||..||:     ::.::..|.||
  Rat   582 TIDRRHRPHHPKHVYVPDR-RSMPAGLALQAVSPQSLHGRTPEELTLLLIKLRRQQAELSSI--- 642

  Fly   446 NETERVDFIVQQLDPHIENTHLIYALCEICHNLM---IYNKHAVFEYKLLYTLAFTPKFIRAVWF 507
            .|......:..:|:.|.....:      :.|:|.   ||..|.:.|.:.:.|:..|.....|:..
  Rat   643 REHTLAQLMQLKLEAHSPKNEI------LSHHLQRNTIYLDHQMKENEPIITMVHTMIENSALRP 701

  Fly   508 KLAAESTQLGFSAPLTLIS----KGVVPKHQGVDRTIPL-LATFC------MLFGRLLPTLHDVE 561
            :|..:..:......|..:|    :|.:.|::..:..|.. |:..|      ......|..||..:
  Rat   702 QLYQQFLRQKNKISLYCLSQDECRGTLYKYRPEEVDIDAKLSRLCEQDKVVRALEEKLQQLHKEK 766

  Fly   562 FVENKLLLQVHSTINHVRLMPFSIAEII--------QMSKTLKDISMGLVEL--AFPE------- 609
            :...:.||.....|......|.:|..::        .:..|.:::|....||  |:.|
  Rat   767 YTLEQALLSASQEIEMNADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYD 831

  Fly   610 ---TRSNLANYRKVLGHTEADD---KKLRHQKQIWANLLNVVVFVLNQIHTRDLRLGFCPEDHWT 668
               ||:.:.:....||..:::.   ::.:.||::|              ..:|:..|
  Rat   832 VTVTRNQMQDQLDRLGEVQSESAGIQRAQIQKELW--------------RIQDVMEG-------- 874

  Fly   669 VTRLDLPLDRPTDLPLTHSSRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILREIPFVVPF 733
                   |.:......:..:.|.|.:||..:: :..|:.|..||..           .:|....|
  Rat   875 -------LSKHKQQRGSSETGLAGPKPFPAVK-YKSEEEEVVPPRP-----------PLPRSYDF 920

  Fly   734 NKRVSILQSLVAASKMRVQGNMQAFLQGPSVLITVRRSHLYEDAYDKLRPDNEPDLR-FKFRIQF 797
            .::..|:..|.:.|     .::..:.:||..|...::||..: .|.:......||.| :|...:.
  Rat   921 TEQPPIIPPLPSDS-----SSLLCYSRGPVHLPEEKKSHQVQ-GYPRNGSHCGPDYRLYKSEPEL 979

  Fly   798 VSSLGLDEA 806
            .:...:||:
  Rat   980 TTVAEVDES 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	9/42 (21%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	5/20 (25%)
Plekha5	NP_647556.1	WW	13..42	CDD:278809
		WW	59..88	CDD:278809
		PH_PEPP1_2_3	165..268	CDD:270068	23/119 (19%)
		PH	171..267	CDD:278594	21/112 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900