DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and Magi3

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_620784.3	Gene:	Magi3 / 245903	RGDID:	621362	Length:	1470	Species:	Rattus norvegicus

Alignment Length:	1056	Identity:	181/1056 - (17%)
Similarity:	316/1056 - (29%)	Gaps:	434/1056 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 RNYFVRLRRLLDD------KCPPLDGETLHAPSPLAEALLQLLLRPLEVAKRASAGGQMSSMSMA 256
            |..|..|.||.|:      .|..:.|:   |||| .:.||::...|:        .|..:..::|
  Rat    39 RGEFPYLGRLRDEPGGGGGTCCVVSGK---APSP-GDVLLEVNGTPV--------SGLTNRDTLA 91

  Fly   257 VCRNFTRDILATPHTDP-------LRYFV-------------------------LPCFAL----- 284
            |.|:| |:.:......|       ||:::                         :||...
  Rat    92 VIRHF-REPIRLKTVKPGKVINKDLRHYLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDG 155

  Fly   285 ---NVDFPFDLLMRSLYDALESAGPAESDSTSSRRSFLFYGV---ETGHKTTRMDSIFSSFLLNS 343
               .||:.|  :....:.|||.:|......|....   |||.   .......:.|.:......|.
  Rat   156 EVPGVDYNF--ISVEQFKALEESGALLESGTYDGN---FYGTPKPPAEPSPFQPDPVDQVLFDNE 215

  Fly   344 LMVLDRRQLATLHQSPLLVIYVRLIAEMMPNILQLPKSTLRGHANAPHRHRDGDDDSEESEDEDE 408
            .....:|:..|            .:::|......||                     ||.||||:
  Rat   216 FDTESQRKRTT------------SVSKMERMDSSLP---------------------EEEEDEDK 247

  Fly   409 ELPAARTLDYDMEQTCRTSGELSVKE-----RECLLESIAILNETER-VDF-----IVQQLDPHI 462
            |             ....||.:..:|     .:|.::::...|:|.| :||     ..:.|:|..
  Rat   248 E-------------AVNGSGSMETREMHSESSDCWMKTVPSYNQTNRSMDFRNYMMRDENLEPLP 299

  Fly   463 ENTHLIYA---------------------LC------EICHNLMI-------------------Y 481
            :|..:.|.                     ||      |.|.:..:                   .
  Rat   300 KNWEMAYTDTGTIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHL 364

  Fly   482 NKHAVFEYKL--------------------LYTLAFT--PKFIRAVWFKLAAESTQLGFSAPLTL 524
            |:...||..:                    :....||  |..::.|..:.:.:.:.:||.  .|:
  Rat   365 NQKTQFENPVEEAKRKKQIGQAETHSAKTDVERAHFTRDPSQLKGVLVRASLKKSTMGFG--FTI 427

  Fly   525 ISKGVVPKHQGVDRTIPLLATFCML-------FGRLLPTLHDVEFVENKLLLQVHS-TINHVRLM 581
            |         |.||....|....:|       .|::.|....|:...|.:|...|: .:...:|:
  Rat   428 I---------GGDRPDEFLQVKNVLKDGPAAQDGKMAPGDVIVDINGNCVLGHTHADVVQMFQLV 483

  Fly   582 PFS--------------------IAEIIQMSKTL--------------KDISMGLV--------- 603
            |.:                    :.:|:..:..:              :|..:|.:
  Rat   484 PVNQYVNLTLCRGYALPDDSEDPVVDIVAATPVINGQSLAKGEACMSTQDFKLGAMVLDQNGKSG 548

  Fly   604 ------ELAFP----ETRSNLANY---------------RKVLGHTEADD--------------- 628
                  .|..|    |.|::||:.               .|..|...||.
  Rat   549 KLLSSDHLNGPSDSNEQRASLASSGSSQPELVTIPLVKGPKGFGFAIADSPTGQKVKMILDSQWC 613

  Fly   629 ---------KKLRHQKQIWANLLNV----VVFVLNQ------IHTRDLRLGFCPEDHWTVTRLDL 674
                     |::.||     |:.|:    ||.||.|      :....||.|.|........:.|.
  Rat   614 QGLQKGDIIKEIYHQ-----NVQNLTHLQVVEVLKQFPVGADVPLLILRGGPCSPTKTAKMKTDT 673

  Fly   675 --------PLDRPTDLPLTHSSRLRGIRPFQP--IRD------------FTREDFENGPPMSTKQ 717
                    .::.||..|:          ||.|  ||.            .::..:|:.|| :||.
  Rat   674 KETSGSLETINEPTPQPM----------PFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPP-NTKD 727

  Fly   718 IRSITILREIPF------------------VVPF-----NKRVSILQSLVAASKMRVQGN----- 754
            :......:|..|                  ::|.     :.|:.....|:....:.|:|.
  Rat   728 LDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQV 792

  Fly   755 ---MQAFLQGPSVLITVRRSHLYEDAYDKLRPDNEPDLRFKFRIQFVSSLG---LDEAGIDGGGV 813
               |....:...||:||||...|.:.    :|::|....|       |..|   |:...:.....
  Rat   793 LDLMTTAARNGHVLLTVRRKIFYGEK----QPEDESPQAF-------SQSGSPRLNRTELPTRSA 846

  Fly   814 FREFLSELIKTAFDPNRGFFMVTTDNKLYPNPNVADLFEDYEKHYYFIGRILGKSIYENLLVELP 878
            .:|....:::...:...||.::|:.:|  |.|.|..         :.|||::..|         |
  Rat   847 PQESYDVILQRKENEGFGFVILTSKSK--PPPGVIP---------HKIGRVIDGS---------P 891

  Fly   879 LAEFFLTKLAGKYSDVDIHQLASLDPELYRNLLYLKDYSGDVSELNLDFTV-----------ASS 932
            .......|:....|.|:...:..|.   :.|::.|...:|    :.:..||           .::
  Rat   892 ADRCGRLKVGDHISAVNGQSIVDLS---HDNIVQLIKDAG----VTVTLTVVAEEEHHGPPSGTN 949

  Fly   933 SLGQTQIVELKPQGQS 948
            |..|:..::.:|.||:
  Rat   950 SARQSPALQHRPMGQA 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	38/197 (19%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	31/175 (18%)
Magi3	NP_620784.3	Interaction with ADRB1 and TGFA. /evidence=ECO:0000269\|PubMed:16316992	18..108		21/81 (26%)
		PDZ_signaling	24..103	CDD:238492	21/76 (28%)
		NK	125..>199	CDD:418433	13/78 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..266		21/130 (16%)
		HUL4	<211..>373	CDD:227354	33/207 (16%)
		WW	299..329	CDD:238122	2/29 (7%)
		WW	345..375	CDD:238122	3/29 (10%)
		Interaction with PTEN. /evidence=ECO:0000250	413..495		17/92 (18%)
		PDZ	416..496	CDD:214570	17/90 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	550..575		6/24 (25%)
		PDZ	578..659	CDD:214570	16/85 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	665..700		8/44 (18%)
		PDZ	729..812	CDD:214570	13/82 (16%)
		Interaction with ADGRB1. /evidence=ECO:0000250	729..811		12/81 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..847		6/39 (15%)
		PDZ_signaling	851..936	CDD:238492	20/111 (18%)
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250	852..939		21/113 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..976		5/27 (19%)
		PDZ_signaling	1023..1101	CDD:238492
		PTZ00112	1115..>1405	CDD:240274
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1124..1146
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1167..1470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900