DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and Plekha7

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_017177675.1	Gene:	Plekha7 / 233765	MGIID:	2445094	Length:	1359	Species:	Mus musculus

Alignment Length:	816	Identity:	161/816 - (19%)
Similarity:	256/816 - (31%)	Gaps:	317/816 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 PHTDPLRYFVLPCFALNVDFPFDLLMRSLYDALESAGP-------AESDSTSSRRSFLFYGVETG 326
            |||...|..|.|        |   ..|...|......|       |::.|...|||....|..|
Mouse   584 PHTPAERVTVKP--------P---EQRRSVDISLGGSPRKARGHAAKNSSHVDRRSMPSMGYMT- 636

  Fly   327 HKTTRMDSIFSSFLLNSLMVLDRRQLATLHQSPLLVIYVRLIAEMMPNILQLPKSTLRGHANAPH 391
             .|....|:....|....::|.|.|   .|||.|..:....:.:::.:.|..|
Mouse   637 -HTVSAPSLHGKSLEELSLLLTRLQ---RHQSKLASVRNFAVGQLLHHYLTFP------------ 685

  Fly   392 RHRDGDDDSEESEDEDEELPAARTLDY-DME-------------------QTCR----TSGELSV 432
                      ..:.:|..|...:.|:| |::                   :.||    .:|...:
Mouse   686 ----------ACQADDTYLQLKKDLEYLDLKIKNNEPLINVLYKVLKKSARGCRPGRSMTGRDLL 740

  Fly   433 KEREC----LLES-----IAILNETERVDFIVQQLDPHI----ENTHLIYALCEICHNL------ 478
            |:|..    :.||     ::|..|.:|   |:|.|:..|    ||...:.::.|:.|..
Mouse   741 KDRSLKPMKIAESDIDVKLSIFCEQDR---ILQDLEDKIRALKENKDQLESVLEVLHRQTEQYRD 802

  Fly   479 ------MIYNKHAVFEYKLLYTLAFTPKFIRAVWFKLAAESTQLGFSAPLTLISKGVVPKHQGVD 537
                  .|..:..:.:..|::        |||   :|..|||::..:
Mouse   803 QPQHLEKITCQQRLLQEDLVH--------IRA---ELCRESTEMENA------------------ 838

  Fly   538 RTIPLLATFCMLFGRLLPTLHDVEFVENKLLLQVHSTINHVRLMPFSIAEIIQMSKTL---KDIS 599
                        :...|....|||        |:..|:.......|...|..|:.|.|   :|:.
Mouse   839 ------------WNEYLKLEKDVE--------QLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVM 883

  Fly   600 MGLVELAFPETRSNLANYRKVLGHTEADDKKLRHQKQIWANLLNVVVFVLNQIHTRDLRLGFCPE 664
            .||        .:|..|||.::|..:..::|            .|.:|
Mouse   884 AGL--------SANKENYRVLVGSVKNPERK------------TVPLF----------------- 911

  Fly   665 DHWTVTRLDLPLDRPTDLPLTHSSRLR---GIRPFQPIRDFTREDFENGPPMSTKQIRSITILRE 726
            .|.:|..|.....:|...|...:|.:|   .:|.|..::.:.  .:...||    |:|.:
Mouse   912 PHPSVPSLSPTESKPALQPSPPTSPVRTPLEVRLFPQLQTYV--PYRPHPP----QLRKV----- 965

  Fly   727 IPFVVPFNKRVSILQSLVAASKMRVQGNMQAFLQGPSVLITVRRSHLYEDAYDKLRPDNEPDLRF 791
                      :|.|||   .:|.:.|...:|..:.|       ...||.       |:::|..
Mouse   966 ----------MSPLQS---PTKAKPQAEDEAPPRPP-------LPELYS-------PEDQPPA-- 1001

  Fly   792 KFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKLYPNPNVADLFEDYEK 856
                  |..|..:...|....|                ||....:.:.|           .|.|:
Mouse  1002 ------VPPLPREATIIRHTSV----------------RGLKRQSDERK-----------RDREQ 1033

  Fly   857 HYYFIGRILGKSIYENLLVELPLAEFFLTKLAGKYSDVDIHQLASLDPELYRNLLYLKDYSGDVS 921
                     |:.:..:|.|||             .|.|...:||||              ||||.
Mouse  1034 ---------GQCVNGDLKVEL-------------RSYVSEPELASL--------------SGDVP 1062

  Fly   922 ELNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNV 986
            :.:|.. |.|.|..||    |..:|.|   .:::|::....||.|   |.:||..||.....:..
Mouse  1063 QPSLSL-VGSESRYQT----LPGRGLS---GSTSRLQQSSTIAPY---VTLRRGLNAENSSATFS 1116

  Fly   987 LP---IEWLYMFSNKELQILISGAEIPIDLEDLKKH 1019
            .|   :|.||  |....:..:|..|   .||.:|:|
Mouse  1117 RPKSALERLY--SGDHQRGKMSAEE---QLERMKRH 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	57/257 (22%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	53/235 (23%)
Plekha7	XP_017177675.1	WW	10..39	CDD:366073
		WW	55..84	CDD:366073
		PH_PEPP1_2_3	158..280	CDD:270068
		Smc	<692..>894	CDD:224117	47/261 (18%)
		PHA03247	<903..1009	CDD:223021	30/180 (17%)
		PRK10263	<912..>1118	CDD:236669	67/325 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900