DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and NEDD4L

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_006722489.1	Gene:	NEDD4L / 23327	HGNCID:	7728	Length:	1019	Species:	Homo sapiens

Alignment Length:	499	Identity:	151/499 - (30%)
Similarity:	246/499 - (49%)	Gaps:	68/499 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   665 DH------WTVTRLDLPLD-------RPTDL-PL-----------------THSSRL----RGIR 694
            ||      |...||..|:.       .|.|| ||                 .|||::    ...|
Human   543 DHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHSSQVLCGENDTR 607

  Fly   695 PFQPIRDFTREDFENGPPMSTKQIRSITILREIPFVVPFNKRVSILQSLVAASKMRVQGNMQAFL 759
            ...|..|.....:|: |.:....|..    ..:|:...|.::....:     .|::...::....
Human   608 ESVPSYDSKITQWED-PRLQNPAITG----PAVPYSREFKQKYDYFR-----KKLKKPADIPNRF 662

  Fly   760 QGPSVLITVRRSHLYEDAYDKLRPDNEPD-LRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIK 823
            :     :.:.|::::|::|.::.....|| |:.:..|:|.|     |.|:|.|||.||:...|.|
Human   663 E-----MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFES-----EKGLDYGGVAREWFFLLSK 717

  Fly   824 TAFDPNRGFFMVT-TDN-KLYPNPNVADLFEDYEKHYYFIGRILGKSIYENLLVELPLAEFFLTK 886
            ..|:|..|.|..: ||| .|..|||.....||:..::.||||:.|.:::...|::......|...
Human   718 EMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKM 782

  Fly   887 LAGKYSDVDIHQLASLDPELYRNLLYLKDYSGDVSELNLDFTVASSSLGQTQIVELKPQGQSIPV 951
            :.||  .:.::.:.|:|.|.|.:|.::.:  .|.:||:|.|.:...:.|||..|:|||.|..|.|
Human   783 MLGK--QITLNDMESVDSEYYNSLKWILE--NDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMV 843

  Fly   952 TNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDL 1016
            ||.|:.||:.|:..::...::::..|||.:|.:.:|||:.:.:|...||::|:.|.. .:|:.|.
Human   844 TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG-DVDVNDW 907

  Fly  1017 KKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDL----DPPFF-IQ 1076
            ::|..|...:.|.||.|..||:.:...|..:|.:||:|||..||.|:.||.:|    .|..| |:
Human   908 RQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIE 972

  Fly  1077 NTGDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGFE 1120
            ..|..|:||.|.||.|.|.|||::|.|.:|||||.|:::..|||
Human   973 QWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	126/361 (35%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	121/338 (36%)
NEDD4L	XP_006722489.1	C2_NEDD4_NEDD4L	21..179	CDD:175999
		WW	224..250	CDD:278809
		WW	413..442	CDD:278809
		WW	526..556	CDD:238122	3/12 (25%)
		WW	575..625	CDD:197736	10/50 (20%)
		HECTc	662..1016	CDD:238033	126/368 (34%)
		HECTc	686..1015	CDD:214523	121/338 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810