DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and Nedd4

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_001344927.1	Gene:	Nedd4 / 17999	MGIID:	97297	Length:	1207	Species:	Mus musculus

Alignment Length:	365	Identity:	118/365 - (32%)
Similarity:	198/365 - (54%)	Gaps:	26/365 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   768 VRRSHLYEDAYDKLRPDNEPD-LRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRG 831
            :||:::.||:|.::......| |:.:..|:|..     |.|:|.|||.||:...:.|..|:|..|
Mouse   854 LRRANILEDSYRRIMGVKRADLLKARLWIEFDG-----EKGLDYGGVAREWFFLISKEMFNPYYG 913

  Fly   832 FFMVT-TDN-KLYPNPNVADLFEDYEKHYYFIGRILGKSIYENLLVE----LPLAEFFLTKLAGK 890
            .|..: ||| .|..|||.....||:..::.||||:.|.::|...|::    .|..:..|.||
Mouse   914 LFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLQKL--- 975

  Fly   891 YSDVDIHQLASLDPELYRNLLYLKDYSGDVSELNLDFTVASSSLGQTQIVELKPQGQSIPVTNSN 955
               :.:|.:.|:|.|.|.:|.::.:  .|.:||:|.|.:.....|||...|||..|..|.|||.|
Mouse   976 ---ITLHDMESVDSEYYSSLRWILE--NDPTELDLRFIIDEELFGQTHQHELKTGGSEIVVTNKN 1035

  Fly   956 RIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLKKHC 1020
            :.||:.|:..::...:|::...||::|...::|.:.:.:|...||::|:.|.. .:|:.|.::|.
Mouse  1036 KKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLG-DVDVNDWREHT 1099

  Fly  1021 EYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDL-----DPPFFIQNTGD 1080
            :|...:|..|..|..||:.:...|..:|.:||:|||..||.|:.||.:|     ...|.::..|.
Mouse  1100 KYKNGYSMNHQVIHWFWKAVWMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGT 1164

  Fly  1081 MERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGFE 1120
            .::||.|.||.|.|.|||:::.:::.:||..||::..||:
Mouse  1165 PDKLPRAHTCFNRLDLPPYESFDELWDKLQMAIENTQGFD 1204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	117/363 (32%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	111/342 (32%)
Nedd4	NP_001344927.1	C2	<477..530	CDD:326325
		WW	574..602	CDD:238122
		WW	727..756	CDD:306827
		WW	781..813	CDD:197736
		HECTc	874..1203	CDD:214523	111/342 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810