DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and hecd-1

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_001368365.1	Gene:	hecd-1 / 177486	WormBaseID:	WBGene00016405	Length:	2650	Species:	Caenorhabditis elegans

Alignment Length:	1212	Identity:	250/1212 - (20%)
Similarity:	383/1212 - (31%)	Gaps:	418/1212 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 SLSHTAQAIPLRMLETFTTVSSVQQYMKDEAVLFQYMERVFGFLIARNYFVRLRRLLDDKCP--- 213
            |::.|.||.....|:        .|....|.:|.:.|...||            |:.:::.|
Worm  1616 SVASTGQAASAESLQ--------HQTPSLENLLARAMPHAFG------------RIAENQEPEDE 1660

  Fly   214 PLDGETLHAPSPLAEALLQLLLRPLEVAKRASAGGQMSSMSMAVCRN------FTRDILATPHT- 271
            |:.||...:.:.:..|              ||:..|||..|.:..:.      ..||...||.|
Worm  1661 PMGGEESDSAASMRSA--------------ASSNSQMSMGSSSQQQQQQDSDMTPRDSAGTPSTP 1711

  Fly   272 -DPLRYFVLPCFALNVDFPFDLLMRSLYDALESAGPAESDSTSSRRSFLFYGVETGHKTTRMDSI 335
             |....      .|:|..|.....|....:.|:.|.|::|.|:|.           .||...|
Worm  1712 RDDKNQ------TLSVSAPDLAAARQRQASAETDGDADADETNSE-----------DKTVGAD-- 1757

  Fly   336 FSSFLLNSLMVLDRRQLATLHQSPLLVIYVRLIAEMMPNILQLPKSTLRGHANAPHRHRDGDDDS 400
                   ..|..|..:..|:..                                  ...|.|||.
Worm  1758 -------DAMEEDDEEEETMED----------------------------------EEDDDDDDD 1781

  Fly   401 EESEDEDEE-----LPAARTLDYDMEQTCRTSGEL-----SVKERECLLESIAILNETERVDFIV 455
            :||.:|::|     |...|.| :|..:...|...|     |.|:        |..||.::..
Worm  1782 DESSNENQEKLVELLGGERGL-FDKLKEVITGESLSDASSSAKD--------ATTNEAQKKG--- 1834

  Fly   456 QQLDPHIENTHLIYALCEICHNLMIYNKHAVFEYKLLYTLAFTPKFIRAVWFKLAAESTQLGFSA 520
                                                    ...||    .|||..:..|.
Worm  1835 ----------------------------------------GKKPK----KWFKKMSSYTD----- 1850

  Fly   521 PLTLISKGVVPKHQGVDRTIPLLATFCM----------LFGRLLPTLHDVEFVENK----LLLQV 571
                :.||::.....|....|..|...|          .|....|  .|.:.||::    |.:.|
Worm  1851 ----VLKGLMQNRYPVALLDPAAAGIEMDEMMDDDDYYDFSEDGP--DDGDSVEDEVAAHLGMPV 1909

  Fly   572 HSTINHV------------RLMPFSIAEIIQMSK--------------TLKDISMGLVELAFPET 610
            .|..:.|            .||..|..|...|::              |:|.....|:....|..
Worm  1910 DSFASMVAARTPITWRQFSELMSGSNRERAAMARAVASSRGSPWEDDATVKCTFEALIPAFDPRP 1974

  Fly   611 -RSN--------LANYRKVLGHTEADDKKLRHQKQI----------------------WANLLNV 644
             |||        |....|..|.|:|...|:....|:                      .|:|...
Worm  1975 GRSNVNQTLEVELPTVVKDFGSTKASSSKIDKDDQMRFFLRGPNMSGVDNVTIEMNDDSASLFRY 2039

  Fly   645 VVFVLNQIH--TRDLR----------LGFCPEDHWTVTRLDLPLDRPTDLP------LTHSSRLR 691
            :..:.|.::  |:..|          :.:|..|...|....:| |..:..|      |.....|.
Worm  2040 MQIINNSVNWATKSDRSRRIWEPTYSICYCSADQTNVEVSKIP-DEESSTPCQVNQCLETIGLLS 2103

  Fly   692 GIRPFQPIRDFTREDF-ENGPPMSTKQIRS---ITILREIP-------------FVVP------- 732
            .|:...|..:.|...| .:...:...|:.|   :...|.:|             |.|.
Worm  2104 RIQQAMPEAEITPNVFISDKLTLKVTQVLSDALVVAARSLPEWCSRLVYKYPCLFTVETRNMYMQ 2168

  Fly   733 -----FNKRVSILQSLVAASKMRVQGNMQA------------------FLQGPSVLITVRRSHLY 774
                 .::.:..||....|:..|.:|:.||                  .|:...|.:|.....|.
Worm  2169 ATAFGVSRTIVWLQQRRDAAVERARGSAQAGNSSAARQHDRYHEYRVGRLRHERVKVTRAEETLL 2233

  Fly   775 EDAYD--KLRPDNEPDLRFKF----------RIQFVS---------SLGL-----DEAGIDGGGV 813
            :.|..  |...|.:..|..::          .::|.:         ||.|     |:......|.
Worm  2234 DQAIRLMKFHADRKAVLEIEYTNEEGTGLGPTLEFYALVAAELQRKSLALWVCDDDDTHASKSGE 2298

  Fly   814 FREF-LSELIKTAFDPNRGFFMVTTDNKLYPNP---------NVADLFEDYEKHYYFIGRILGKS 868
            .||. |.|..|..     |:: |.....|:|.|         ..||:|.       .:|..|.|.
Worm  2299 EREVDLGEGKKPI-----GYY-VRRVGGLFPAPLPPGTDETKRAADMFR-------VLGVFLAKV 2350

  Fly   869 IYENLLVELPLAEFFLTKLAGKYSDVD-----IHQLASLD----------------------PEL 906
            :.:..||:|||:..||..|.......|     :|::.|||                      ..|
Worm  2351 LLDGRLVDLPLSRPFLKLLVHPQIGDDARGPNLHKILSLDDFEEVNPVKGSFLKELRALAQRKRL 2415

  Fly   907 YRN----------------LLYLKDYSGDVSELNLDFTV-ASSSLGQTQIVELKPQGQSIPVTNS 954
            ..|                .|::|..:..|.:|.|:||| ..|.:.|...:||...|..|.||..
Worm  2416 IENDTSIDSNSKRRKIAELKLHIKGSTCRVEDLALNFTVNPPSKVFQYAEMELVDGGSDIDVTID 2480

  Fly   955 NRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIP-IDLEDLKK 1018
            |..:|::...::.||..|.....|||.|...|.|:..|..:|.:|:|.|:||.:.| ...:|:..
Worm  2481 NVEQYVEKCEEFYLNTGIAYQMRAFRDGFDRVFPLRTLRAYSPEEVQRLLSGEQCPEWSRDDILN 2545

  Fly  1019 HCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPPFFI---QNTGD 1080
            :.|....::.|.|..:.|.:|:|.....:|:..|:|.|.||..|..|..:|.|...|   ..:||
Worm  2546 YTEPKLGYTRESPGFLRFVDVMEALTAQERKNFLQFATGCSSLPPGGLANLHPRLTIVRKVESGD 2610

  Fly  1081 MERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGFELS 1122
             ...|:.:||.:.||||.:.:...:||:||.||.. .||.|:
Worm  2611 -GSYPSVNTCVHYLKLPEYSSSAILRERLLTAINE-KGFHLN 2650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	112/437 (26%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	106/412 (26%)
hecd-1	NP_001368365.1	Ank_2	345..436	CDD:403870
		ANK repeat	345..372	CDD:293786
		ANK repeat	374..403	CDD:293786
		PTZ00322	383..>497	CDD:140343
		ANK repeat	405..436	CDD:293786
		F5_F8_type_C	1243..1365	CDD:419973
		MIB_HERC2	1452..1509	CDD:399589
		HECTc	2221..2648	CDD:238033	113/441 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900