DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and hecw-1

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_001317872.1	Gene:	hecw-1 / 175438	WormBaseID:	WBGene00009738	Length:	1247	Species:	Caenorhabditis elegans

Alignment Length:	406	Identity:	110/406 - (27%)
Similarity:	186/406 - (45%)	Gaps:	33/406 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   737 VSILQSLVAASKMRVQG---NMQAFLQ---------GPSVLI-TVRRSHLYEDAYDKLRPDNEPD 788
            :::..|::.::..::.|   |::.|.:         |||.|. .|.|..|.:||: ::..:.:|.
Worm   853 ITLALSMLDSNTEKLAGEGDNIKMFYEDMKKEKLGKGPSRLCWKVSRDRLLDDAF-RIILNVDPF 916

  Fly   789 LRFKFR--IQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVT-TDNKLYPNPNVADL 850
            :..|.|  |:|...|.||.     ||:.|||...|.:..|.|..|:|... .|..|...|...:.
Worm   917 VLKKSRLHIRFEGELALDY-----GGLSREFFILLSRELFHPKNGYFEYEGNDYHLQLRPRGCET 976

  Fly   851 FEDYEKHYYFIGRILGKSIYENLLVELPLAEFFLTKLAGKYSDVDIHQLASLDPELYRNLLYLKD 915
             |..:|.....||:|..::.....:::.....|...|..:  .|.:......|.|.|:::.:|.:
Worm   977 -EKEKKWLILCGRVLALAVIHRCYIDVFFTNVFYKSLQKR--PVTLMDFKESDAEFYKSMNWLLE 1038

  Fly   916 YSGDVSELNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFR 980
              .||.:|.:.|..:|...|:....||.|.|:|..||.:|:.|::.|:...|....:.:......
Worm  1039 --NDVVDLEMSFVYSSMVNGKLAEQELVPGGESQMVTEANKAEFIDLMCQKKAIRGVEKPLEILL 1101

  Fly   981 KGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDD 1045
            ...:.:|....|....:.:|:.::||: :.:||.|.:.:..|.|.:|..|..:..||||:|...:
Worm  1102 TSFNQILNDNLLNSLESSDLKRILSGS-LELDLNDWRTNTIYKGGYSDCHIVVEWFWEVIETMTN 1165

  Fly  1046 MQRRQLLKFVTSCSRPPLLGFKDLD-----PPFFIQNTGDMERLPTASTCTNLLKLPPFKTVEQM 1105
            .:|..||.|||..|..|..||..|.     ..|.|:..||....|.|.||.|.|:||.:.|.:|:
Worm  1166 QERFDLLLFVTGSSSVPFEGFSALRGNEEISKFCIEKWGDATSFPRAHTCFNRLQLPSYNTKQQL 1230

  Fly  1106 REKLLYAIQSGAGFEL 1121
            :.||..||.:|..:.:
Worm  1231 KSKLQQAIVNGMSYSI 1246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	102/362 (28%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	96/338 (28%)
hecw-1	NP_001317872.1	FBA_2	230..285	CDD:311601
		WW	603..634	CDD:197736
		WW	746..777	CDD:197736
		HECTc	918..1244	CDD:214523	96/336 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810