DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and etc-1

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_495842.1	Gene:	etc-1 / 174388	WormBaseID:	WBGene00008429	Length:	1001	Species:	Caenorhabditis elegans

Alignment Length:	1165	Identity:	319/1165 - (27%)
Similarity:	503/1165 - (43%)	Gaps:	236/1165 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DRDTVIRKAALERQKRNELRQKENGAVVLQSYARSFIHRQRRKRAEREVFDIYLMGHKDGIVEDE 88
            :||..:.:......||.:..::|..|..:|.:.|....:..::...|..||. :...:.|:.|..
Worm     7 ERDNFLNRLREMEHKREKDEKQEKAARKVQKFWRGHRVQHNQRLLFRAEFDA-VSDRQRGLEETI 70

  Fly    89 SLTFLLRRLNFFYSIREAKDSERLIEVCQQI-------------LRQPARLLQHSSPDSLWLLRL 140
            .:..||  :||:   ...||.|||:....::             :|:..|||         |.|.
Worm    71 KMAQLL--VNFY---ETNKDEERLVMTLSELVKLKTSDKEFEKRIRETQRLL---------LARC 121

  Fly   141 C-KLLDTCLLQLSLSHTAQAIPLRMLETFTTVSSVQQYMKDEAVLFQYMERVFGFLIARNYFVRL 204
            | |.|..........|.     .|.||.:.|..|         .||:...:: |...|..:
Worm   122 CIKFLKNATENTIFFHI-----FRYLEDYVTCHS---------KLFEASSKL-GLFNAEFH---- 167

  Fly   205 RRLLDDKCPPLDGETLHAPSPLAEALLQLLLRPLEVAKRASAGGQMSSMSMAVCRNFTRDILATP 269
              ||:.......|:|:...| |...:||||.|..|.....|   :.:|:|:.|.....:.|
Worm   168 --LLEALIGKPTGKTVERAS-LNPRILQLLTRIFETFVNPS---RSTSVSVNVANRLLKTI---- 222

  Fly   270 HTDPLRYFVLPCFALNV-DFPF-DLLMRSLYDALESAGPAESDSTSSRRSFLFYGVETGHKTTRM 332
                         .:|: |..| :.::..:.|.::...|                    :.|...
Worm   223 -------------CVNITDLNFSNYILYYIKDHIKPTSP--------------------NFTNLF 254

  Fly   333 DSIFSSFLLNSLMVLDRRQLATLHQSPLLVIYVRLIAEMMPNILQLPKSTLRGHANAPHRHRDGD 397
            :::.|..:||:..|  |.::|......|..|:|..|..:
Worm   255 EAMKSVDILNNWKV--RPEIAETASLRLQSIFVSQIVHV-------------------------- 291

  Fly   398 DDSEESEDEDEELPAARTLDYDMEQTCRTSGELSVKERECLLESIAILNETERVDFIVQQLDPHI 462
             .:.:|||..:..   .:|...:|...:....|:|||.         |:|..|:...|
Worm   292 -SNTQSEDVKQYF---NSLAVFLEHHSKIMRSLNVKED---------LSEFGRLRTSV------- 336

  Fly   463 ENTHLIYALCEICHNLMIYN--KHAVFEYKLL-----YTLAFTPKFIRAVWFKLAAESTQLGFSA 520
             |.|    |.:.|..::|.|  :.|...|..|     .|:....|:.......|||.:|   |..
Worm   337 -NNH----LKQYCEEMLISNEFRRAACIYANLPGVQVETIISLRKYFSQFLDLLAASNT---FVE 393

  Fly   521 PLTLISKGVVP--KHQGVDRTIP---LLATFCMLFGRLLPTLHDVEFVENKLLLQVHSTINHVRL 580
            .|......:.|  :...:|...|   .|..||....:.:.::.|.:||...:.:....|:
Worm   394 ALYAFIARLCPNGEFDPIDAKSPKVNALELFCNCLNKRVSSVADSDFVPTDIFVDFDHTV----- 453

  Fly   581 MPFSIAEIIQMSKTLKDISMGLVELAFPE-TRSNL--ANYRKVLGHTEADDKKLRHQKQIWANLL 642
                        :.|:|:|:.|:.|.||. .|.:|  .|.::.:...|.|          |.::.
Worm   454 ------------EFLRDVSIKLIHLMFPTMARGDLYSGNLKEKMYKAETD----------WKDVT 496

  Fly   643 NVVVFVLNQIHTRDLRLGFCPEDHWT---------------VTRLDLP-----LDRPTDLPLTHS 687
            ..|..:|..|:.:|:||.:.||:.||               :.|..:|     ::|..|....
Worm   497 ESVFSILGAIYQKDIRLKYFPEEFWTNHGREVLSGIGEHRRMPRRRMPNGRLQIERTMDTEFV-- 559

  Fly   688 SRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILREIPFVVPFNKRVSILQSLVAASKMR-V 751
            .||..|.......:...||.:|..|...:  |:|.:::.|||:|||..||.:...|:...|.: .
Worm   560 ERLAAIYEMDSDSENDDEDEDNNLPAVLR--RAICVMKHIPFIVPFMDRVKLFTRLLNQDKEKHY 622

  Fly   752 QGNMQAFLQGPSVLITVRRSHLYEDAYD----KLRPDNEPDLRFKFRIQFVSSLGLDEAGIDGGG 812
            .........||||  ||||..:|.||::    |::.|...||:...|::.|:..|::|:||||||
Worm   623 TSTFGMGFNGPSV--TVRRDQVYMDAFETFAPKMQGDKVNDLKSMVRVKMVNWAGMNESGIDGGG 685

  Fly   813 VFREFLSELIKTAFDPNRGFFMVTTDNKLYPNPNVADLF-EDYEKHYYFIGRILGKSIYENLLVE 876
            :||||||||:||||:..||||..|....|||||....|. .|...|:.||||::||.|||..|.|
Worm   686 IFREFLSELLKTAFNVERGFFTFTESKLLYPNPTAPFLLGVDCLAHFQFIGRMIGKLIYERQLQE 750

  Fly   877 LPLAEFFLTKL--AGKYSDVDIHQLASLDPELYRNLLYLKDYSG-DVSELNLDFTVASSSLGQTQ 938
            :..||||:.::  ..|..|||:..:.|.||.::::|..|:..:. ::.||.|||:|.:|.:|..:
Worm   751 VRFAEFFIAQIFETDKNKDVDLQHMKSFDPIIFKHLKALQKMNNRELDELQLDFSVVTSDMGLVR 815

  Fly   939 IVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQIL 1003
            .|.|||.|....||..|..||::|..:|.|..:|....:|.|||:|.::.|||:.||:..||||:
Worm   816 NVNLKPNGSKFRVTVENVHEYVRLYVNYHLKQRIASMVDAVRKGISEIISIEWMRMFAPHELQIM 880

  Fly  1004 ISGAEIPIDLEDLKKHCEYGGEFSPEHPSI---VTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLG 1065
            |:|.|.....::|:|.||.  .|:.....|   ..||:|::...:..::.||||||.|||.|:.|
Worm   881 IAGYEEVFTAKELRKFCEL--RFAAGTQDINYEEMFWDVIDKLSNDDKKALLKFVTGCSRAPVDG 943

  Fly  1066 FKDLDP---PFFIQNTGDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGFELS 1122
            ||.:.|   ...|.::.|  .|||::||.|:|::|.:....::.|||.|||.|||||||:
Worm   944 FKSIQPRMGVLVIPSSDD--ELPTSATCMNMLRIPKYSNRTKLEEKLRYAINSGAGFELA 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	152/367 (41%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	142/340 (42%)
etc-1	NP_495842.1	HECTc	661..998	CDD:214523	142/340 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167079
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	1.000	Inparanoid score	I1501
Isobase	1	0.950	-	0	Normalized mean entropy	S2801
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1163565at2759
OrthoFinder	1	1.000	-	-		FOG0005112
OrthoInspector	1	1.000	-	-		oto18372
orthoMCL	1	0.900	-	-		OOG6_100865
Panther	1	1.100	-	-	LDO	PTHR45700
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1831
SonicParanoid	1	1.000	-	-		X3631
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.740