DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and PLEKHA7

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_024304124.1	Gene:	PLEKHA7 / 144100	HGNCID:	27049	Length:	1365	Species:	Homo sapiens

Alignment Length:	857	Identity:	166/857 - (19%)
Similarity:	274/857 - (31%)	Gaps:	289/857 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 PHTDPLRYFVL-PCFALNVDFPFDLLMRSLYDALESA-GPAESDSTS-SRRSFLFYGVETGHKTT 330
            |||...|..|. |....:||.       ||.|:...| |.|..:|:. .|||....|..|  .|.
Human   587 PHTPAERVTVKPPDQRRSVDI-------SLGDSPRRARGHAVKNSSHVDRRSMPSMGYMT--HTV 642

  Fly   331 RMDSIFSSFL--LNSLMVLDRRQLATLHQSPLLVIYVRLIAEMMPNILQLPKSTLRGHANAPHRH 393
            ...|:....|  |:.|:...||     ||:.|..:....|::::.:.|..|
Human   643 SAPSLHGKSLEELSLLLTRLRR-----HQAKLASVRNFAISQLLQHQLTFP-------------- 688

  Fly   394 RDGDDDSEESEDEDEELPAARTLDY-DME-------------------QTCR----TSGELSVKE 434
                    ..:.:|..|...:.|:| |::                   :.||    .:|...:|:
Human   689 --------TCQADDTYLQLKKDLEYLDLKIKNNEPLINVLYKVLKKSARGCRPRRSMTGRDLLKD 745

  Fly   435 REC----LLES-----IAILNETERVDFIVQQLDPHI----ENTHLIYALCEICHNLM-IYNKHA 485
            |..    :.||     ::|..|.:||   :|.|:..|    ||...:.::.|:.|..| .|....
Human   746 RSLKPVKIAESDTDVKLSIFCEQDRV---LQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQP 807

  Fly   486 VFEYKLLYTLAFTPKFIRAVWFKLAAESTQLGFSAPLTLISKGVVPKHQGVDRTIPLLATFCMLF 550
            ....|:.|......:.:..:..:|:.|||::..:                              :
Human   808 QHLEKIAYQQKLLQEDLVHIRAELSRESTEMENA------------------------------W 842

  Fly   551 GRLLPTLHDVEFVENKLLLQVHSTINHVRLMPFSIAEIIQMSKTL---KDISMGLVELAFPETRS 612
            ...|...:|||        |:..|:.......|...|..|:.|.|   :|::.||        .:
Human   843 NEYLKLENDVE--------QLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGL--------SA 891

  Fly   613 NLANYRKVLGHTEADDKKLRHQKQIWANLLNVVVFVLNQIHTRDLRLGFCPEDHWTVTRLDLPLD 677
            |..|:|.::...:..::|            .|.:|                 .|..|..|.....
Human   892 NKENFRILVESVKNPERK------------TVPLF-----------------PHPPVPSLSTSES 927

  Fly   678 RPTDLPLTHSSRLR---GIRPFQPIRDFTREDFENGPPMSTKQIRSITI---------------- 723
            :|...|...:|.:|   .:|.|..::.:.  .:...||    |:|.:|.
Human   928 KPPPQPSPPTSPVRTPLEVRLFPQLQTYV--PYRPHPP----QLRKVTSPLQSPTKAKPKVQEDE 986

  Fly   724 ------LREI-------PFVVPFNKRVSILQSLVAASKMR--------------VQGNMQAFLQG 761
                  |.|:       |.|.|..:..:|::........|              |.|:.:..|
Human   987 APPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDRELGQCVNGDSRVEL-- 1049

  Fly   762 PSVLITVRRSHLYEDAYDKLRPD-NEPDLRF---KFRIQFVSSLGLDEAGIDGGGVFREFLSELI 822
                    ||::.|.....|..| .:|.|..   :.|.|.:...||      .|...|...|..|
Human  1050 --------RSYVSEPELATLSGDMAQPSLGLVGPESRYQTLPGRGL------SGSTSRLQQSSTI 1100

  Fly   823 KTAFDPNRGFFMVTTDNKLYPNPNVA-----------------DLFEDYEKHYYFIGRILGKSIY 870
            .......|| ....:....:|.|..|                 :..|..::|...:.|...:::.
Human  1101 APYVTLRRG-LNAESSKATFPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLG 1164

  Fly   871 ENLLVELPLAEFFLTKLAG------KYSDVDIHQLASL------DPELYRNLLYLKDYSGDVSEL 923
            :.....||.:.:....|.|      :..|.|:..|..:      |.|   ...:||..:..|:||
Human  1165 QGERTGLPSSRYLSRPLPGDLGSWKREQDFDLQLLERVVQGEKKDKE---ENGWLKVQAMPVTEL 1226

  Fly   924 NL---DFTVASSSLGQTQIVEL-KPQGQSIP-------VTNSNRIEYLQLIADYKLNVQIRRHCN 977
            :|   |:.:..|.       || ||:..|||       ......:|.||  |.|:...:||   |
Human  1227 DLEPQDYDLDISR-------ELSKPEKVSIPERYVELDPEEPPSLEELQ--ARYRKAEKIR---N 1279

  Fly   978 AF-RKGLSNVLP 988
            .. |..:.|:.|
Human  1280 ILARSSMCNLQP 1291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	58/268 (22%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	52/245 (21%)
PLEKHA7	XP_024304124.1	WW	11..40	CDD:306827
		WW	56..85	CDD:306827
		PH_PEPP1_2_3	159..281	CDD:270068
		NESP55	<299..460	CDD:115071
		DUF1640	779..905	CDD:311647	30/171 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900