DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and HECTD2

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_001271203.2	Gene:	HECTD2 / 143279	HGNCID:	26736	Length:	780	Species:	Homo sapiens

Alignment Length:	1000	Identity:	227/1000 - (22%)
Similarity:	346/1000 - (34%)	Gaps:	319/1000 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 ETLHAPSPLAEALLQLLLRPLEVAKRA------------------SAG------------GQMSS 252
            |.:..|||..         ||.||..|                  |||            ||:|:
Human     3 EAVRVPSPAT---------PLVVAAPAPEERKGKESEREKLPPIVSAGAGATAGLDRGAKGQIST 58

  Fly   253 MSMAVCRNFTRDILATPHTDPLRYFVLPCFALNVDFPFDLLM------RSLYDALESAGPA---- 307
            .|..:.....:...|...:.| .:.|.|... ||..|..:.:      |:..||..|...|
Human    59 FSSFISAVSPKKEAAENRSSP-AHLVFPNIK-NVREPPPICLDVRQKQRTSMDASSSEMKAPVLP 121

  Fly   308 --------------ESDSTSSRRSFLFYGVETGHKTTRMDSIFSSF-LLNSLMVLD-RRQLATLH 356
                          :.|....:.|..:..|...:.||     |.|| .||:....| .....|:.
Human   122 EPILPIQPKTVKDFQEDVEKVKSSGDWKAVHDFYLTT-----FDSFPELNAAFKKDATASFNTIE 181

  Fly   357 QSPLLVIYVRLIAEMMPNILQ-LPKSTLRGHANAPHRHRDGDDDSEESEDEDEELPAARTLDYDM 420
            .|.:...:|..:.:.:.|..| :.|:.|:|..|:..|...|.
Human   182 DSGINAKFVNAVYDTLLNTPQDVQKTVLKGIINSLLREWKGP----------------------- 223

  Fly   421 EQTCRTSGELSVKERECLLESIAILNETERVDFIVQQLDPHIEN--THLIYA--------LCEIC 475
                ||..:|                   |..||:.| :|...|  |::|||        |.|..
Human   224 ----RTKDDL-------------------RAYFILLQ-NPQFNNTSTYVIYAHLLRQIATLVEAD 264

  Fly   476 HNLMIYNKHAVFEYKLLYTLAFTPKFIRAVWFKLAAESTQLGFSAPLTLISKGVVPKHQGVDRTI 540
            |:.:::                        |||  .:.::|.
Human   265 HHFLVH------------------------WFK--KQYSRLS----------------------- 280

  Fly   541 PLLATFCMLFGRLLPTLHDVEFVENKLLLQVHSTINHVRLMPFSIAEIIQMSKTLKDISMGLVEL 605
              ...|..|..|||      :|:.             :||.|....|...::|....|......|
Human   281 --QKRFKQLVERLL------QFIS-------------LRLFPAKPEEFPPITKCSWWIPSAAKVL 324

  Fly   606 AFPETRSNLAN---------YRKVLGHTEADDKKLRHQKQIWANLLNVVVFVLNQIHTRDLRLGF 661
            |...|.:||.:         |...|.|.:     |..:...|.|..|            ..|..|
Human   325 ALLNTANNLVHPPLIPYTDFYNSTLDHID-----LMEEYHTWQNFGN------------SHRFSF 372

  Fly   662 CPEDHWTVTRLDLPLDRPTDLPLTHSSRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILRE 726
            |                  ..|...|...:.|        ..:.|.|.         :.|.|.|
Human   373 C------------------QYPFVISVAAKKI--------IIQRDSEQ---------QMINIAR- 401

  Fly   727 IPFVVPFNKRVSILQSLVAASKMRVQGNMQ-AFLQGPSVLITVRRSHLYEDAYDKLRPDNEPDLR 790
                          ||||.....|.:.:|. .||.     :.|||:||..|:.|:| .....||:
Human   402 --------------QSLVDKVSRRQRPDMNILFLN-----MKVRRTHLVSDSLDEL-TRKRADLK 446

  Fly   791 FKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKLYPNPNVADLFEDYE 855
            .|.::.||.     |||:|.||:.:|:...||:..|.|:.|.|....|:..:       .|..::
Human   447 KKLKVTFVG-----EAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCH-------WFSSFK 499

  Fly   856 ----KHYYFIGRILGKSIYENLLVELPLAEFFLTKLAGK------------YSDVDIHQLASLDP 904
                ..:..:|.::|.::|.::.:::........||...            ..:|.:..|..:.|
Human   500 CDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMP 564

  Fly   905 ELYRNLLYLKDYSGDVSE-LNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKL 968
            ||...|..|..:.|:|.| ....|.|.....|..:...|||.|..|.|||.||.||:||..|:.|
Human   565 ELAHGLSELLSHEGNVEEDFYSTFQVFQEEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLL 629

  Fly   969 NVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLKKHCEYGGEFSPEHPSI 1033
            |..|.:...||..|..:|.....|.:...:|::||:.|:. .:|:..|::..:|.| ::....:|
Human   630 NKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSP-DLDMHALQRSTQYDG-YAKTDLTI 692

  Fly  1034 VTFWEVLEGFD-DMQRRQLLKFVTSCSRPPLLGFKDLDPPFFI-QNTGDMERLPTASTCTNLLKL 1096
            ..||:|:.||. |:|:: ||.|.|...|.|:.|..||:  |.| :|......||.|.||.|.|.|
Human   693 KYFWDVVLGFPLDLQKK-LLHFTTGSDRVPVGGMADLN--FKISKNETSTNCLPVAHTCFNQLCL 754

  Fly  1097 PPFKTVEQMREKLLYAIQSGAGFEL 1121
            ||:|:.:.:::||:..|.:..||.|
Human   755 PPYKSKKDLKQKLIIGISNSEGFGL 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	112/372 (30%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	103/349 (30%)
HECTD2	NP_001271203.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		12/51 (24%)
HECTD2	NP_001271203.2	HECTc	421..778	CDD:238033	113/379 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810