DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and WWP2

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_001257383.1	Gene:	WWP2 / 11060	HGNCID:	16804	Length:	870	Species:	Homo sapiens

Alignment Length:	370	Identity:	122/370 - (32%)
Similarity:	188/370 - (50%)	Gaps:	26/370 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   762 PS-VLITVRRSHLYEDAYDKLRPDNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTA 825
            || |.|:|.|..|:||::.::......|||   |..::...|  |.|:|.||:.||:...|....
Human   512 PSHVKISVSRQTLFEDSFQQIMNMKPYDLR---RRLYIIMRG--EEGLDYGGIAREWFFLLSHEV 571

  Fly   826 FDPNRGFFMVTTDNK--LYPNPNVADLFEDYEKHYYFIGRILGKSIYENLLVE----LPLAEFFL 884
            .:|....|.....|.  |..|| .:.:..|:..::.||||.:..::|....::    ||..:..|
Human   572 LNPMYCLFEYAGKNNYCLQINP-ASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRML 635

  Fly   885 TKLAGKYSDVDIHQLASLDPELYRNLLYLKDYSGDVSELNLDFTVASSSLGQTQIVELKPQGQSI 949
            .|..      .:..|.|:|||.|.:::::|:.:.:...|.|.|......||:....|||..|:||
Human   636 NKRP------TLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESI 694

  Fly   950 PVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLE 1014
            .||..|:.||:.|:.|::....:.....||..|.:.|.|:|||..|..|||::::.|.: .||:.
Human   695 RVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQ-EIDMS 758

  Fly  1015 DLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDL-----DPPFF 1074
            |.:|...| ..::.....|..||:|::..|:.:|.:||:|||...|.|:.||.:|     ...|.
Human   759 DWQKSTIY-RHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFC 822

  Fly  1075 IQNTGDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGF 1119
            |...|....||.:.||.|.|.|||:|:.||:||||||||:...||
Human   823 IDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	119/365 (33%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	111/341 (33%)
WWP2	NP_001257383.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..299
		Atrophin-1	<164..343	CDD:331285
		WW	302..331	CDD:306827
		WW	332..361	CDD:306827
		WW	407..435	CDD:306827
		WW	447..477	CDD:238122
		HECTc	516..868	CDD:238033	119/366 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810