DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and itcha

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_001274024.1	Gene:	itcha / 100331274	ZFINID:	ZDB-GENE-120919-4	Length:	851	Species:	Danio rerio

Alignment Length:	423	Identity:	129/423 - (30%)
Similarity:	212/423 - (50%)	Gaps:	42/423 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   704 REDFENGPPMSTKQIRSITILREIPFVVPFNKRVSILQSLVAASKMRVQGNMQAFLQGPSVLITV 768
            :...||||              :|.:|..|..:|...:..           .|.......:.|.|
Zfish   461 KSSLENGP--------------QITYVRDFKAKVHYFRFW-----------CQQLSMPQHIKIHV 500

  Fly   769 RRSHLYEDAYDKLRPDNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFF 833
            .|..|:||::.::...:..|||.:..|.|..     |.|:|.|||.||:...|.....:|....|
Zfish   501 SRKTLFEDSFQQIMGCHPQDLRRRLWIIFPG-----EEGLDYGGVAREWFFLLSHEVLNPMYCLF 560

  Fly   834 -MVTTDNK-LYPNPNVADLFEDYEKHYYFIGRILGKSIYENLLVELPLAEFFLTKLAGKYSDVDI 896
             ....||. |..|| .:.:..|:.|::.||||.:..:::....::...:..|..::..|  .:.:
Zfish   561 EYAGKDNYCLQINP-ASSINPDHLKYFKFIGRFIAMALFHGKFIDTGFSLPFYKRILNK--PLAL 622

  Fly   897 HQLASLDPELYRNLLYLKDYSGDVSELNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQ 961
            ..|.|:|||.|.:|:::||.:.:...|.:.|:|....||:....||||.|.:|.||..|:.||::
Zfish   623 KDLESIDPEFYNSLIWIKDNNIEECGLEMFFSVDKEILGEVTTHELKPDGGNIQVTEENKEEYIR 687

  Fly   962 LIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLKKHCEYGGEF 1026
            |:|:::|:..:.....||.:|.::|||.::|..|..|||::::.|.: .|||.|.:::..| ..:
Zfish   688 LVAEWRLSRGVEEQTQAFLEGFNDVLPQQYLQYFDAKELEVMLCGMQ-EIDLGDWQRNSIY-RHY 750

  Fly  1027 SPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDL-----DPPFFIQNTGDMERLPT 1086
            :.....||.||:.::..|:.:|.:||:|||...|.|:.||.||     ...|.|:..|....||.
Zfish   751 ARSSKQIVWFWQFVKEMDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPR 815

  Fly  1087 ASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGF 1119
            :.||.|.|.|||:|:.||::||||:||:...||
Zfish   816 SHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	120/361 (33%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	112/337 (33%)
itcha	NP_001274024.1	C2_E3_ubiquitin_ligase	2..125	CDD:175988
		WW	276..305	CDD:278809
		WW	308..337	CDD:278809
		WW	387..418	CDD:197736
		WW	427..458	CDD:197736
		HECTc	496..849	CDD:238033	120/363 (33%)
		HECTc	520..848	CDD:214523	112/337 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910