DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and herc5.4

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_005160166.1	Gene:	herc5.4 / 100148091	ZFINID:	ZDB-GENE-090311-7	Length:	995	Species:	Danio rerio

Alignment Length:	664	Identity:	155/664 - (23%)
Similarity:	262/664 - (39%)	Gaps:	163/664 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   532 KHQGVDRTIPLLATFCMLFG--------------RLLPTLH----DVEFVENKLLLQVHSTINHV 578
            :|.|:|..: :..:|..||.              .|||:|:    .||.:  :|.|.:...||.:
Zfish   416 EHCGLDFDL-VKTSFAKLFASKSLISEVVKVVQQTLLPSLNPNPTGVEAL--RLYLLLPELINGL 477

  Fly   579 RLMPFSIAEIIQMSKTLKDISMGLVELAFPETRSNLANYRKVLG------------------HTE 625
            :.         |.:|.::.::..::||       |.| .||||.                  |.|
Zfish   478 KK---------QRTKLIEALASKILEL-------NSA-ARKVLEMYWSRLPDDWFERLIKLFHKE 525

  Fly   626 A-----------DDKKLRHQKQIWANLLNVVVFVLNQIHTRDLRLGF---CPEDHWTVTRLDLPL 676
            :           |.:..||.|    |:|.:            |::.:   |..|   :|..|..:
Zfish   526 STDLIDQICDETDHQSTRHLK----NILEI------------LQMAYQISCSTD---ITHHDFII 571

  Fly   677 DRPT---DLPLTHSSRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILREIPFVVPF---NK 735
            .:..   ||..|.::.|..:..:..|    .|||.:...:.....|::.||.:.||...|   .:
Zfish   572 HKINDLLDLLQTITADLLRMELYMQI----NEDFHDMVKLEEYYFRTVKILVKFPFASDFITKQR 632

  Fly   736 RVSILQSLVAASKMRVQGNMQAFLQGPSV--------LITVRRSHLYEDAYDKLRPDNEPDLRFK 792
            ..::||.             :.|...|::        |:.:.|..:..|....|| .|.......
Zfish   633 MFNLLQE-------------ECFRNVPNLAMGNSFSNLLHINRESVLTDTLQYLR-QNTHSFMHP 683

  Fly   793 FRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKLYPNPNVADLFEDYEKH 857
            .::.|:.     |.|||..|:..||.|.:.|:..:.::....|...:.::.||:    .....|:
Zfish   684 LQVAFIG-----EDGIDMRGLSAEFFSLISKSFIEWDKKILEVHESSLVWFNPH----HTRGNKN 739

  Fly   858 YYFIGRILGKSIY--ENLLVELPLAEFFLTKLAGKYSDVDIHQLASLDPELYRNLLYLKDYSGDV 920
            :|::|.|.|.::|  .::.::.||| .|...|..|.|..|:.:|:.::....:|||. :|....|
Zfish   740 FYYLGVICGMALYNRHHINIDFPLA-LFKKLLQQKPSLDDLEELSPVEARSLKNLLE-EDEEEVV 802

  Fly   921 SELNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSN 985
            :..:||||..    ||    ||.|.|..|.|...||.:|:.|..|.:.|..::.....|.:|.|.
Zfish   803 NLQHLDFTCK----GQ----ELVPNGSQIQVNKVNRQKYVDLYVDLEFNKSVKTQFEQFTRGFSK 859

  Fly   986 VLPIEWLYMFSNKELQILISGAEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQ 1050
            ..|::...||..:|||.|:.|:. ..:.::|::...|.| .|.....|..||.|.....:..:::
Zfish   860 GCPLDAWTMFHPEELQELLHGSP-QYNWKELQQSASYEG-CSASDELIKNFWTVFFELSEENKKK 922

  Fly  1051 LLKFVTSCSRPPLLGFKDL----------DPPFFIQNTGDMERLPTASTCTNLLKLPPFKTVEQM 1105
            .|.|:....|.|..|....          ||.         :.||.|.||...|.||.:..:..:
Zfish   923 FLMFLYGTERVPAGGLSKRALKISQTDCPDPD---------DHLPEAQTCFERLVLPKYSDINTL 978

  Fly  1106 REKLLYAIQSGAGF 1119
            .:||::||.|.|.|
Zfish   979 HDKLIHAINSCAVF 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	97/366 (27%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	91/342 (27%)
herc5.4	XP_005160166.1	RCC1_2	117..146	CDD:290274
		RCC1	133..183	CDD:278826
		RCC1	186..235	CDD:278826
		RCC1	239..286	CDD:278826
		RCC1	294..343	CDD:278826
		HECTc	658..993	CDD:294058	97/366 (27%)
		HECTc	682..992	CDD:214523	91/339 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810