DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and herc3

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_001139096.1	Gene:	herc3 / 100003587	ZFINID:	ZDB-GENE-090313-139	Length:	1046	Species:	Danio rerio

Alignment Length:	661	Identity:	172/661 - (26%)
Similarity:	277/661 - (41%)	Gaps:	135/661 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   531 PKHQGVD-RTIPLLATFCM--LFGRLLPTLHDVEFVENKLLLQVHSTINHVRLMPFSIAEIIQMS 592
            ||..|:| ..:.||....|  .|.|||..:  .:..|:.|:.|:..:...|..|  .|..|:...
Zfish   450 PKVPGIDFNAVRLLFETLMKPAFARLLEQI--TKSFESLLIPQLPCSPPDVEAM--RIYLILSEC 510

  Fly   593 KTLKDISMGLVELAFPETRSNL---ANYRKVLGHTEADDKKLRHQKQIWANLLNVVVF------- 647
            ...:| |...:.|..|...:.|   ||..|||.:              |.:|::..||
Zfish   511 PAFQD-SKNYITLTIPLAMAILRLDANPSKVLDN--------------WWSLMDCTVFTRLVEMY 560

  Fly   648 -----------------------------VLNQIHTRDLRLGFCPEDHWTV----TRLDLPLD-- 677
                                         :|.::|..:|:......:|:.:    |.:|:..|
Zfish   561 KSIVVFLLTGGKALLMPVFLESYTSAALRLLEKLHKVNLKAHRVEYNHFYIPDIATLVDIQEDYL 625

  Fly   678 ----RPTDLPLTHSSRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILREIPFVVPFNKRVS 738
                |..|:.:.:                        ||:.    .|:| |...||::....:.:
Zfish   626 KWFLRKADIKMRY------------------------PPVQ----GSVT-LCAYPFILNAQAKTT 661

  Fly   739 ILQS-LVAASKMRVQG----------NMQAFL-QGPSVLITVRRSHLYEDAYDKLRPDNEPDLRF 791
            :||: .....:|.|.|          .|:..| :.|.:::.|||:||..||..:|...|:.||:.
Zfish   662 VLQTDAELQMQMAVSGANLHNVFMLLTMEPLLARNPFLVLHVRRNHLVSDALRELTIYNDVDLKK 726

  Fly   792 KFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKLYPNPNVADLFED--Y 854
            ..::.|..     |..:|.|||.:||...|:|...:|..|.|...:::.|.       .|.|  :
Zfish   727 PLKVIFDG-----EEAVDAGGVTKEFFLLLLKELMNPIYGMFTQYSESNLL-------WFSDKCF 779

  Fly   855 EKHYYF--IGRILGKSIYENLLVELPLAEFFLTKLAGKYSDVDIHQLASLDPELYRNLLYLKDYS 917
            .:|.:|  ||.|.|.:||.:.:|:|........||......:|  .|..|.|...|:|..|.::.
Zfish   780 VEHNWFHLIGIICGLAIYNSTVVDLHFPLVLYKKLLEISPTLD--DLKELSPTEGRSLQQLLEFE 842

  Fly   918 GDVSE-LNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRK 981
            |||.| ..|:|.:.....|.|::.||...|::|.|..:||.|::|....|..:..::...:||..
Zfish   843 GDVEETFCLNFAITREYYGITEVKELVQGGKTIAVDKTNRKEFVQAYLQYVFSDAVQEQYSAFSS 907

  Fly   982 GLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDM 1046
            |...|...|.|.:|...||..::.|.. ..:.|:::|:..|.||||..||::..||||...|...
Zfish   908 GFLKVCGGEILSLFQPSELMAMVVGNN-NYNWEEMEKNASYKGEFSATHPTVKMFWEVFHEFSLE 971

  Fly  1047 QRRQLLKFVTSCSRPPLLGFKDLDPPFFIQNTGDMER-LPTASTCTNLLKLPPFKTVEQMREKLL 1110
            :::|.|.|:|...|.|:.|...|  ...||:|...|. ||.|.||.|:|.:|.::|.|.:|::|.
Zfish   972 KKKQFLLFLTGSDRIPIHGMASL--RIVIQSTAAEEHYLPVAHTCYNMLDMPCYQTKETLRQRLT 1034

  Fly  1111 YAIQSGAGFEL 1121
            .|::...||.|
Zfish  1035 QAVEQYEGFSL 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	114/359 (32%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	104/336 (31%)
herc3	NP_001139096.1	RCC1	4..49	CDD:278826
		RCC1_2	37..65	CDD:290274
		RCC1	52..99	CDD:278826
		RCC1	103..152	CDD:278826
		RCC1	155..205	CDD:278826
		RCC1	208..257	CDD:278826
		RCC1	260..308	CDD:278826
		RCC1	314..374	CDD:278826
		HECTc	699..1044	CDD:238033	114/361 (32%)
		HECTc	723..1043	CDD:214523	104/336 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810