DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cN-IIIB and Nt5c3

DIOPT Version :9

Sequence 1:	NP_611895.1	Gene:	cN-IIIB / 37875	FlyBaseID:	FBgn0034988	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_080280.3	Gene:	Nt5c3 / 107569	MGIID:	1927186	Length:	331	Species:	Mus musculus

Alignment Length:	302	Identity:	113/302 - (37%)
Similarity:	188/302 - (62%)	Gaps:	9/302 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FDEKREPTGGRLR-LQDIPALTQDHCRMRDPAEVERIINEFVIGGPERMQIVSDFDYTITKQRTE 66
            |..||: ||.:.: ::.:|...:...|:::|..||.||...:.||..::||::|||.|::: .:.
Mouse    31 FTLKRK-TGRKTKIIEMMPEFQKSSVRIKNPTRVEEIICGLIKGGAAKLQIITDFDMTLSR-FSY 93

  Fly    67 DGGAVPSSFGIFNACQSLPENFKAETDKLYHKYRPIEIDPHMPIAEKVQYMIEWWTKSGEL--TS 129
            :|...|:...|.:.|:.:.:..:.:..:|..:|..||:||.:.:.||..||:||:|||..|  ..
Mouse    94 NGKRCPTCHNIIDNCKLVTDECRRKLLQLKEQYYAIEVDPVLTVEEKFPYMVEWYTKSHGLLIEQ 158

  Fly   130 GFPFDQSEIDQIASKYTHALRDRTHEFFADLQRLGIPTLVFSAGLGNSVVSVLRQANVLHPNVKV 194
            |.|  ::::.:|.:.....|::....||..||:.|||..:||||:|:.:..|:|||.|.|.||||
Mouse   159 GIP--KAKLKEIVADSDVMLKEGYENFFGKLQQHGIPVFIFSAGIGDVLEEVIRQAGVYHSNVKV 221

  Fly   195 VSNFLQF-RDGLLDGFQQPMIHTFNKNETVLNETSEYYDLVHTRDHIIVMGDSIGDADMASGVPA 258
            ||||:.| .:|:|.||:..:||.|||::..|..| :|:..:....:||::|||.||..||.||..
Mouse   222 VSNFMDFDENGVLKGFKGELIHVFNKHDGALKNT-DYFSQLKDNSNIILLGDSQGDLRMADGVAN 285

  Fly   259 SSHIMKIGFLFDHVEANMKKYMDTFDIVLVDDQTMDVPRTLL 300
            ..||:|||:|.|.|:..::||||::|||||.:::::|..::|
Mouse   286 VEHILKIGYLNDRVDELLEKYMDSYDIVLVKEESLEVVNSIL 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cN-IIIB	NP_611895.1	HAD-SF-IE	22..303	CDD:273683	107/282 (38%)
Nt5c3	NP_080280.3	HAD_like	50..329	CDD:304363	107/282 (38%)
Nt5c3	NP_080280.3	Substrate binding. /evidence=ECO:0000269\|PubMed:16672222	198..200		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839994
Domainoid	1	1.000	200	1.000	Domainoid score	I3032
eggNOG	1	0.900	-	-		E1_KOG3128
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	227	1.000	Inparanoid score	I3462
Isobase	1	0.950	-	0	Normalized mean entropy	S4406
OMA	1	1.010	-	-		QHG57847
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003221
OrthoInspector	1	1.000	-	-		otm42964
orthoMCL	1	0.900	-	-		OOG6_103467
Panther	1	1.100	-	-	O	PTHR13045
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2376
SonicParanoid	1	1.000	-	-		X2179
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740