DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ocm and EOMES

DIOPT Version :9

Sequence 1:	NP_001188998.1	Gene:	ocm / 37874	FlyBaseID:	FBgn0266083	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_001265111.1	Gene:	EOMES / 8320	HGNCID:	3372	Length:	705	Species:	Homo sapiens

Alignment Length:	477	Identity:	86/477 - (18%)
Similarity:	148/477 - (31%)	Gaps:	176/477 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1468 QTSLLMKNRSRDLKRKSQADERLLPSGPSMTKSSKPSAGGYPIAASVATSTTSAFASSSGKSTPV 1532
            ||.:::..:.|          |:.|..........|:| .|.:...|..:..:.:....||....
Human   284 QTEMIITKQGR----------RMFPFLSFNINGLNPTA-HYNVFVEVVLADPNHWRFQGGKWVTC 337

  Fly  1533 CTAKTNSASTK----NKSSATG---IRSNIEFRKV--------NHNDVDELQIPELHQTDHRWVV 1582
            ..|..|....|    .:|..||   :|..|.|.|:        |:|:...:.:..||:...|..:
Human   338 GKADNNMQGNKMYVHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHI 402

  Fly  1583 LDIFDD-FSHIFVPSFSDMISLTRIHSVMQVAEERQKVVKLQFFPNA-------PYDAFVTPSSK 1639
            :::.:| ...:..||.:...:.:....:...|.:...:.:|:...|.       .||:..|.|..
Human   403 VEVTEDGVEDLNEPSKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSMYTASEN 467

  Fly  1640 KKIYFGPLSLDMP-------------------PPVLVLLQSVDRKMMLREVYQREHSIPVQRHRR 1685
            .::  .|...|.|                   |.|..|.|:        ..|..|.::|
Human   468 DRL--TPSPTDSPRSHQIVPGGRYGVQSFFPEPFVNTLPQA--------RYYNGERTVP------ 516

  Fly  1686 SMAFWVLQINGQVHFEIDTESTAKLAAQQKNAIGTP-----------PGLNVLKI---------- 1729
                   |.||            .|:.||...:..|           ||.|.|.|
Human   517 -------QTNG------------LLSPQQSEEVANPPQRWLVTPVQQPGTNKLDISSYESEYTSS 562

  Fly  1730 ----------PSQLSVEIEKNQDEVPPVVVIDSDEEDDDG-------ERQL-------------V 1764
                      |.|.|..:....|...|.:.         |       :|::             |
Human   563 TLLPYGIKSLPLQTSHALGYYPDPTFPAMA---------GWGGRGSYQRKMAAGLPWTSRTSPTV 618

  Fly  1765 IDEQDDEQAETDVKQEVERTGFTIQTLPSSGAL---------------QITISDSAETSSHPAK- 1813
            ..|  |:.::..||:|:..:  .|:|.||..:|               :::.|:|:..:|...|
Human   619 FSE--DQLSKEKVKEEIGSS--WIETPPSIKSLDSNDSGVYTSACKRRRLSPSNSSNENSPSIKC 679

  Fly  1814 -DVNTCHFS-------GGFMPF 1827
             |:|...:|       ||:..|
Human   680 EDINAEEYSKDTSKGMGGYYAF 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ocm	NP_001188998.1	DUF4801	771..821	CDD:292677
EOMES	NP_001265111.1	TBOX	267..460	CDD:238106	33/186 (18%)
EOMES	NP_001265111.1	T-box_assoc	482..703	CDD:292794	47/266 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141554
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830