DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ocm and TBXT

DIOPT Version :9

Sequence 1:	NP_001188998.1	Gene:	ocm / 37874	FlyBaseID:	FBgn0266083	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_001353214.1	Gene:	TBXT / 6862	HGNCID:	11515	Length:	436	Species:	Homo sapiens

Alignment Length:	423	Identity:	87/423 - (20%)
Similarity:	131/423 - (30%)	Gaps:	152/423 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1626 PNAPYDAFVTPSSKKKIYFGPLSLDMPPPVLVLLQSVDRKM------MLREVYQREHSIPVQRHR 1684
            |.||...::.|.|..   ||  :..|..||......:..|:      ||..:::.|..|.:.|
Human   117 PQAPSCVYIHPDSPN---FG--AHWMKAPVSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVR-- 174

  Fly  1685 RSMAFWVLQING-----QVHFEIDTESTAKLAAQQKNAIGTPPGLNVLKIPSQLSVEIEKNQDEV 1744
                     :.|     ..|...:|:..|..|.|.:.       :..|||......:
Human   175 ---------VGGPQRMITSHCFPETQFIAVTAYQNEE-------ITALKIKYNPFAK-------- 215

  Fly  1745 PPVVVIDSDEEDDDGERQLVIDEQDDEQAETDVKQEVERTGFTIQ---TLPSS------------ 1794
               ..:|:.|..|..|   :::|..|.|          :.|::..   .||.:
Human   216 ---AFLDAKERSDHKE---MMEEPGDSQ----------QPGYSQSGGWLLPGTSTLCPPANPHPQ 264

  Fly  1795 --GALQITISDSAE---------TSSHPAKDVNTCHFSGGFMPFIANVPAKFGETAPTTQFLTP- 1847
              |||.:..:.|.:         :|.:|:                   |......:||....:|
Human   265 FGGALSLPSTHSCDRYPTLRSHRSSPYPS-------------------PYAHRNNSPTYSDNSPA 310

  Fly  1848 -----QVQVTTSQSG----PETLTSSSSSHLPASKSAYPKINESLQELFSSGVPPGGITITKVDS 1903
                 |.....|..|    |..|..|.::..|.|.|.||    ||..:.:..|.||        |
Human   311 CLSMLQSHDNWSSLGMPAHPSMLPVSHNASPPTSSSQYP----SLWSVSNGAVTPG--------S 363

  Fly  1904 QEKTLPNETVQVVKNKKSIAITGIHKQVTKAASSTATVTAARAPVVKPQSTSVSKVAPPIRPGAT 1968
            |...:.|               |:..|..:  .|.|..|....||..|.|:     ..|:..||.
Human   364 QAAAVSN---------------GLGAQFFR--GSPAHYTPLTHPVSAPSSS-----GSPLYEGAA 406

  Fly  1969 TQPKTLVRLYPKPALAAGRKSLPANAKTPVATP 2001
            .....:...|  .|.|.||  |.| :.|||:.|
Human   407 AATDIVDSQY--DAAAQGR--LIA-SWTPVSPP 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ocm	NP_001188998.1	DUF4801	771..821	CDD:292677
TBXT	NP_001353214.1	T-box	44..219	CDD:307177	25/135 (19%)
TBXT	NP_001353214.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..309		5/47 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141546
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830