DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ocm and tbr1b

DIOPT Version :9

Sequence 1:	NP_001188998.1	Gene:	ocm / 37874	FlyBaseID:	FBgn0266083	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_001108562.1	Gene:	tbr1b / 58042	ZFINID:	ZDB-GENE-000323-1	Length:	676	Species:	Danio rerio

Alignment Length:	718	Identity:	134/718 - (18%)
Similarity:	227/718 - (31%)	Gaps:	222/718 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1488 ERLLPSGPSMTKSSKPS--AGGYPIAASVATSTTSAFASSSG----KSTPVCTAKTNSASTKNKS 1546
            ||.:  .|::.:|.|..  ..|||.|.:...:.......|.|    :|:|:   |.|||...|:|
Zfish     4 ERCI--SPALARSKKCMIVGSGYPNAQASELALQDYPIISIGDNLERSSPL---KKNSAGMTNQS 63

  Fly  1547 SATGIRSNIEFRKVNHNDVDELQI-PELHQTDHRWVVLDIFDDFSHIFVPSFSDMISLTR----- 1605
            .|    .|....|.:..||...:: |:          ||...|..|.|..|..:...|::
Zfish    64 EA----DNFADSKDSSGDVQRGKLSPD----------LDGVADSRHTFDGSAGERYLLSQSSQVQ 114

  Fly  1606 ---------------IHSVMQVAEERQKVVKLQFFPNAPYDAFVTPSSKK--------------K 1641
                           .|....:|...:.:.......|..|::.::.||.:              .
Zfish   115 PSPTTMFPYPSQHGPTHPAFSIASPSRYMAHHPVITNGAYNSLLSNSSPQGYATAGYPYAQQYGH 179

  Fly  1642 IYFGPLSLD--------MPPPVLVLLQSVDRKMMLREVYQREHSIPVQRHRRSMAFWVLQING-- 1696
            .|.|.....        :|....|.|  .:|.:.|:....:...|..::.||...|....|:|
Zfish   180 AYQGTAFYQFSSAQAGLVPGKAQVYL--CNRALWLKFHRHQTEMIITKQGRRMFPFLSFNISGLD 242

  Fly  1697 -QVHFEI-------------------------DTESTAKLAAQQKNAIGTPPGLNVLKIPSQLSV 1735
             ..|:.|                         ||..|........::..|  |.:.::
Zfish   243 PTAHYNIFVDVILADPNHWRFQGGKWVPCGKADTNVTGNRVYMHPDSPNT--GAHWMR------- 298

  Fly  1736 EIEKNQDEVPPVVVIDSDEEDDDGERQLVIDEQDDEQAETDVKQEVERTG--FTIQTL----PSS 1794
                              :|...|:.:|           |:.|.....||  ..:|:|    |..
Zfish   299 ------------------QEISFGKLKL-----------TNNKGATNNTGQMVVLQSLHKYQPRL 334

  Fly  1795 GALQITISDSAETSSHPAKDVNTCHFSGGFMPFIANVPAKFGETAPTTQFLTPQVQVTTSQSGPE 1859
            ..:|:. .|..|.:|.|.: |.|..|                   |.|||    :.||..|:  .
Zfish   335 HVVQVN-EDGTEDTSQPGR-VQTFTF-------------------PETQF----IAVTAYQN--T 372

  Fly  1860 TLTSSSSSHLPASKSAYPKINESLQELFSSGVPPGGITITKVDS-QEKTLPNE----TVQVVKNK 1919
            .:|.....|.|.:|.    ..::...:: :|.....:|.:..|| :.:.:|:.    |...::::
Zfish   373 DITQLKIDHNPFAKG----FRDNYDTVY-TGCDIDRLTPSPGDSPRSQIMPSARYAMTGSFLQDQ 432

  Fly  1920 --KSIAITGIHKQVTKAASSTATVTAARAPVVKPQSTSVSKVAPPIRPGATTQPKTLVRLYPKPA 1982
              .|.|.:..|..|..|..:..:|..:.: ::.||.|..:.||.|.|...|
Zfish   433 FVSSYAKSRFHPGVGGAPGTDRSVPLSNS-LLSPQQTEETTVASPQRWFVT-------------- 482

  Fly  1983 LAAGRKSLPANAKTPVATPRQSQPVACDKPPLVSGSTLPALVEPSAR-KSLP-------SKPLAA 2039
                    |||.:...|........|.|    .:|:....|...:|. |:||       ::||
Zfish   483 --------PANNRLDFAASAYDAAAAAD----FAGNAATLLSYAAAGVKALPLPGAGCSNRPL-- 533

  Fly  2040 GEHLRPRQSLPAKVTANPPAAARPDAASTSAQNLTNVSKAQLAKEEICYGIMVAKDLPRFRAKVE 2104
            |.:..|    |...|..||......::..|.....:|.....|...:..|:.....:...|:.:.
Zfish   534 GYYGEP----PGWGTRTPPQYCSKSSSVLSCWPSNSVGSRTTASSYLVPGLEDGDPIAPERSPLG 594

  Fly  2105 GSD 2107
            |:|
Zfish   595 GAD 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ocm	NP_001188998.1	DUF4801	771..821	CDD:292677
tbr1b	NP_001108562.1	TBOX	200..393	CDD:238106	46/263 (17%)
tbr1b	NP_001108562.1	T-box_assoc	415..673	CDD:292794	43/216 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574534
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830