DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ocm and H15

DIOPT Version :9

Sequence 1:	NP_001188998.1	Gene:	ocm / 37874	FlyBaseID:	FBgn0266083	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_608926.2	Gene:	H15 / 33769	FlyBaseID:	FBgn0016660	Length:	660	Species:	Drosophila melanogaster

Alignment Length:	599	Identity:	118/599 - (19%)
Similarity:	182/599 - (30%)	Gaps:	254/599 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 KRRLQNVRHWSKGLVNYYKKMGRIEEHEETEVYRVAEPLAAEELSKQMKQQLELLKTGKRSLSLI 150
            ::|.|...|.:.|     |:..:...|..:.....:....:...||...|:       .||.:.:
  Fly   176 QQRQQTHHHATTG-----KQQRQHHNHHSSNTNNSSNSGNSNTNSKSSSQR-------GRSAAAV 228

  Fly   151 EETTAIAEVPPKKPKQFPDITEEARVINDSDDRLDAAPSKQAAERTPTKSPAQVAASEDVPTPAT 215
             ...|....||..|.|.|:..|          ||           :|.:||||      .|||..
  Fly   229 -GAAATPSPPPPPPSQSPEELE----------RL-----------SPEESPAQ------QPTPKI 265

  Fly   216 PSKEQSGQTSTCSSAEKT------------DKVEKVGGGSKFLDMLISK--------VRVKNFA- 259
                    ..:|:..:.|            ||..::|     .:|:|:|        ||| :|:
  Fly   266 --------VGSCNCDDLTPVQCHLETKELWDKFHELG-----TEMIITKSGRRMFPTVRV-SFSG 316

  Fly   260 -RENNMPAEPSAVTFCTSEDEGSADFVGFDESVHQPGMLLTPLVPNNCKTTEGNSAFVSESLD-- 321
             .....||:..||                          |..:||                ||
  Fly   317 PLRQIQPADRYAV--------------------------LLDVVP----------------LDSR 339

  Fly   322 ----AYMREHHINDSDSQDDKDKLLEPMGHDGQVTSHSMPPP-------MDMPAVPEALQRLRTV 375
                ||.|...:                     |...:.|||       .|.|..||||::
  Fly   340 RYRYAYHRSSWL---------------------VAGKADPPPPSRIYAHPDCPLSPEALRK---- 379

  Fly   376 AERRQYLQRCKNHKMGIINNEAN-----VYRELQRKQ-RQRKVKIGAMQALQASDSQMPFTRQGW 434
                   |.....|:.:.|||.:     |...:.|.| |...|::...|::..|..::    |..
  Fly   380 -------QVVSFEKVKLTNNEMDKSGQVVLNSMHRYQPRIHLVRLSHGQSIPGSPKEL----QDM 433

  Fly   435 QAASYVATEH-----SKYYYQVIQVDGEMVRLPGAQGNNLKREKSPYL------SRLSRKEQEEL 488
            ...::|..|.     :.|..|:|              ..||.:.:|:.      ||||..:::.
  Fly   434 DHKTFVFPETVFTAVTAYQNQLI--------------TKLKIDSNPFAKGFRDSSRLSDFDRDP- 483

  Fly   489 KCSEQCLDA-RIQQELKVIPTRVSPPRNPKILNQYPLPAIFRPCPLSKKPLQRPLDDDTAALLLA 552
                  :|| ...|.::..|.|                  |.|.||..:  ..|.:.|.|
  Fly   484 ------MDAFFFDQHMRTAPLR------------------FFPDPLMSQ--LTPQEADAA----- 517

  Fly   553 GGSMAVVSMPNVELDVMPQLGRPLDEIAKRYLQHILPHHDITREWAEFSVSTLQAPPATMKDA-- 615
              |||::......|.:   .||      ..|.:.:|||      ..:.|.:....|||....|
  Fly   518 --SMALLEKARQHLQM---FGR------SPYTEMLLPH------LYQRSAAPPPPPPAPHLSAFQ 565

  Fly   616 ----EEQASQTPAG 625
                ::|..|..||
  Fly   566 LGMWQQQWPQLTAG 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ocm	NP_001188998.1	DUF4801	771..821	CDD:292677
H15	NP_608926.2	TBOX	276..475	CDD:238106	53/296 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439052
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11267
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.930