DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ocm and Tbx4

DIOPT Version :9

Sequence 1:	NP_001188998.1	Gene:	ocm / 37874	FlyBaseID:	FBgn0266083	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	XP_006247098.1	Gene:	Tbx4 / 303399	RGDID:	1309057	Length:	555	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	108/581 - (18%)
Similarity:	182/581 - (31%)	Gaps:	212/581 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 QAAERTPTKSPAQVAASE--DVPTPATPSKEQSG----------------QTSTCSSAEKTDKVE 237
            :.|.|.|..:..:.:.|.  :||.||..:...||                ..:..::||:|.:..
  Rat    11 EEAFRAPGPALGETSNSNNTNVPEPALATPGLSGTALSSPPGQGADVAAAAAAAAAAAEQTIENI 75

  Fly   238 KVGGGSKFL---------DMLISKVRVKNFARENNMPAEPSAVTFCTSEDEGSADFVGFDESVHQ 293
            |||...|.|         :|:|:|...:.|      |:....||             |.:.....
  Rat    76 KVGLHEKELWKKFHEAGTEMIITKAGRRMF------PSYKVKVT-------------GMNPKTKY 121

  Fly   294 PGMLLTPLVPNNCKTTEGNSAFVSESLDAYMREHHINDSDSQDDKDKLLEPMGHDGQVTSHSMPP 358
              :||..:||.:                    :|.....|::.......|| ...|::..|.
  Rat   122 --ILLIDIVPAD--------------------DHRYKFCDNKWMVAGKAEP-AMPGRLYVHP--- 160

  Fly   359 PMDMPAVPEALQRLRTVAERRQYLQRCKNHKMGIINNEANVYRELQRKQRQRKVKIGAMQALQ-- 421
              |.||......|           |.....|:.:.||..:.:..         :.:.:|...|
  Rat   161 --DSPATGAHWMR-----------QLVSFQKLKLTNNHLDPFGH---------IILNSMHKYQPR 203

  Fly   422 ----ASDSQMPFTRQGWQAASYVATEHSKYYYQVIQVDGEMVRLPGAQGNNLKREKSPYLSRLSR 482
                .:|....|..:.....::|..|.|  :..|.......:       ..||.|.:|:......
  Rat   204 LHIVKADENNAFGSKNTAFCTHVFPETS--FISVTSYQNHKI-------TQLKIENNPFAKGFRG 259

  Fly   483 KEQEELKCSEQCLDARIQQELKVIPTRVSPPRNPKILNQYPLPAIFRPCPLSKKPLQRPLDDDTA 547
            .:..:|:.      ||:|.:                  :||:        :||..:::.|
  Rat   260 SDDSDLRV------ARLQSK------------------EYPV--------ISKSIMRQRL----- 287

  Fly   548 ALLLAGGSMAVVSMPNVELDVMPQLGRPLDEIAKRYLQHILPHHDITREWAEFSVSTLQAPPATM 612
                      |.|..:.:.||.|.      ....:.|||....:....::|.
  Rat   288 ----------VSSQLSAKPDVSPL------HSTHQALQHYQYENGAHMQFAA------------- 323

  Fly   613 KDAEEQ---ASQTPAGRRKSFTFVIPYLNDRNHILVRRVVDRSEHLD----RSFKEEPNKL-QEF 669
              ||.|   .:..|..|..|..:         |.|.|| .|.:.|||    ||:.|.|:.: .:.
  Rat   324 --AEPQDLPLNTFPTQRDSSLFY---------HCLKRR-ADSARHLDLPCKRSYLETPSSVGDDH 376

  Fly   670 TFREMLPPQPDAEIVA---CAEMISDMINTVAISCSENSFISEDPDALDASSVPKSSDLCP 727
            .||.  ||..|.::::   |:|:      |...:|   .:.|..|:....|:|   .||.|
  Rat   377 YFRS--PPPYDQQMLSPSYCSEV------TPREAC---MYSSSGPEIAGVSAV---DDLPP 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ocm	NP_001188998.1	DUF4801	771..821	CDD:292677
Tbx4	XP_006247098.1	TBOX	74..263	CDD:238106	43/264 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335241
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830