DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ocm and tbx5a

DIOPT Version :9

Sequence 1:	NP_001188998.1	Gene:	ocm / 37874	FlyBaseID:	FBgn0266083	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_001300611.1	Gene:	tbx5a / 30071	ZFINID:	ZDB-GENE-991124-7	Length:	492	Species:	Danio rerio

Alignment Length:	555	Identity:	100/555 - (18%)
Similarity:	168/555 - (30%)	Gaps:	214/555 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 DSDD--RLDAAPSKQAAE--RTPTKSPAQVAASEDVPTPATPSKEQ--SGQTSTCSSAEKTDKVE 237
            ||:|  ||..:||....:  :...||..|.||....|:..|...:|  .|........|...|..
Zfish     3 DSEDTFRLQNSPSDSEPKDLQNEGKSDKQNAAVSKSPSSQTTYIQQGMEGIKVYLHERELWTKFH 67

  Fly   238 KVGGGSKFLDMLISKV-----------------RVKNFARENNMPAEPSAVTFCTSE--DEGSAD 283
            :||     .:|:|:|.                 :.|.....:.:||:.....|..::  ..|.|:
Zfish    68 EVG-----TEMIITKAGRRMFPSFKVKVTGLNPKTKYILLMDVVPADDHRYKFADNKWSVTGKAE 127

  Fly   284 FVGFDESVHQPGMLLTPLVPNNCKTTEGNSAFVSESLDAYMREHHINDSDSQDDKDKLLEPMGHD 348
                   ...||.|.  :.|::..|    .|.....|.::.:....|:.         |:|.||.
Zfish   128 -------PAMPGRLY--VHPDSPAT----GAHWMRQLVSFQKLKLTNNH---------LDPFGHI 170

  Fly   349 GQVTSHSMPPPMDMPAVPE--------------ALQRLRTVAERRQYLQRCKNHKMGIINNEANV 399
            ...:.|...|.:.:....|              .......:|     :...:|||:..:..|.|.
Zfish   171 ILNSMHKYQPRIHIVKADENNGFGSKNTAFCTHVFPETAFIA-----VTSYQNHKITQLKIENNP 230

  Fly   400 Y---------RELQRKQRQRKVK-------------IGAMQALQASDSQMPFTR--QGWQAASYV 440
            :         .||.|..|.:..|             :|:        ||.||:.  ||..|:..:
Zfish   231 FAKGFRGSDDMELHRMSRMQSTKEYPVVPRSTVRQRVGS--------SQSPFSGDVQGLSASGAI 287

  Fly   441 ATEHSKYYYQVIQVDGEMVRLPGAQGNNLKREKSPYLSRLSRKEQEELKCSEQCLDARIQQELKV 505
            ::::|            ......:...:|..:.|.|         .|......|:..:::.|
Zfish   288 SSQYS------------CENGVSSTSQDLLPQSSSY---------HEHTQDYHCIKRKVEDE--- 328

  Fly   506 IPTRVSPPRNPKILNQYPLPAIFRPCPLSKKPLQRPL------DDD--------TAALLLAGG-- 554
                                     ||..:.|.::|.      :||        :.:|.|:||
Zfish   329 -------------------------CPAGEHPYKKPYVESSSSEDDHYYRPLSYSQSLGLSGGAP 368

  Fly   555 ------------------------SMAVVSMPNVELDVMPQLGR-PLDEIAKRYLQHILPHHDIT 594
                                    |:..:|.|.|....:||:.| |        .||....|..:
Zfish   369 YRPESSQRQACMYASAPQPPEPVPSLEDISWPGVPPYSVPQMERLP--------YQHHFSAHFAS 425

  Fly   595 REWAE------FSVS-------TLQAPPATMKDAE 616
            |:..|      .|||       .:|:|.|.::..|
Zfish   426 RQMPEAHGMYASSVSHQCSPSGGIQSPSAGLQGNE 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ocm	NP_001188998.1	DUF4801	771..821	CDD:292677
tbx5a	NP_001300611.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		13/39 (33%)
		TBOX	52..240	CDD:238106	35/219 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..352		4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574532
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830