DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ocm and Mga

DIOPT Version :9

Sequence 1:	NP_001188998.1	Gene:	ocm / 37874	FlyBaseID:	FBgn0266083	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	XP_006499750.1	Gene:	Mga / 29808	MGIID:	1352483	Length:	3091	Species:	Mus musculus

Alignment Length:	2726	Identity:	469/2726 - (17%)
Similarity:	831/2726 - (30%)	Gaps:	986/2726 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 DPRLKRMIKR--RLQNVR------HW---SKGLVNYYKKMGRIEEHEETEVY-----------RV 120
            ||.|::.:||  ::.|:.      .|   |.|:..  .||.:::..:...||           ::
Mouse   419 DPILEKQLKRHNKVDNLEADHPSYKWLPNSPGVAK--AKMFKLDAGKMPVVYLEPCAVTKSTVKI 481

  Fly   121 AE----PLAAEELSKQMKQQLELL---------------KTGKRS-------LSLIEETTAIAEV 159
            :|    .|:.....|.|..:||.|               |..:.|       |.::::.|.:
Mouse   482 SELPDNMLSTSRKDKSMLAELEYLPAYIENSDGTDFCLSKDSENSLRKHSPDLRIVQKYTLL--- 543

  Fly   160 PPKKPK-QFPDITEEARVINDSDDRLDAAPSKQAAERTPTKS--------------PAQVAASED 209
              |:|. ::|||.:     |.|.:|:..:.....||....|.              |::...:..
Mouse   544 --KEPNWKYPDILD-----NSSTERIHDSSKGSTAESFSGKEDLGKKRTTMLKMAIPSKTVTASH 601

  Fly   210 VPTPATPSKEQSGQTSTCSSAEKTDKVEKVGGGSKFLDMLISKVRVKNFARENNMPAEPSA---- 270
            ..:|.||.|....:....|.|.:..|  ..|               |:.....|:|..|.:
Mouse   602 SASPNTPGKRGRPRKLRLSKAGRPPK--NTG---------------KSLTAAKNIPVGPGSTFPD 649

  Fly   271 ----------VTFCTSEDEGSADFVGFDESVHQPGMLLTPLV-PNNCKTTEGNSAFVSESLDAYM 324
                      |.|.:.|.:.:.|....|.:..:|..|.|... .:.|:|.      :|:     :
Mouse   650 VKPDLEDVDGVLFVSFESKEALDIHAVDGTTEEPSSLQTTTTNDSGCRTR------ISQ-----L 703

  Fly   325 REHHINDSDSQDDKDKLLEPMGHDGQVTSHSMPPP---------MDMPAVPEALQRLRTVAERRQ 380
            .:..|.|..|...| :::.|...:..:..:|:.|.         :.:|..|.....|..|.
Mouse   704 EKELIEDLKSLRHK-QVIHPALQEVGLKLNSVDPTVSIDLKYLGVQLPLAPATSFPLWNVT---- 763

  Fly   381 YLQRCKNHKMGIINNEANVYRELQRKQRQRKVKIGAMQALQASDSQMPFTR-----------QGW 434
                                              |...|  :.|:..||..           :||
Mouse   764 ----------------------------------GTNPA--SPDAGFPFVSRTGKTNDFTKIKGW 792

  Fly   435 QAASYVATEHSKYYYQVIQVDGEMVRLPGAQGNNLKREKSPYLSRLSRKEQEELKCSEQCLDARI 499
            :.....|:....                  :|.|         |..|.|.:... ||:: ||..:
Mouse   793 RGKFQNASASRN------------------EGGN---------SEASLKNRSAF-CSDK-LDEYL 828

  Fly   500 QQELKVIPTRV----SPPRNPKILNQYPLPAIFRPCPLSKKPLQRPLDDDTAALLLAGGSMAVVS 560
            :.|.|::.|.:    :.|.:|.:   |.||.       ......|.||    ::|....:::
Mouse   829 ENEGKLMETNIGFSSNAPTSPVV---YQLPT-------KSTSYVRTLD----SVLKKQSTIS--- 876

  Fly   561 MPNVELDVMPQLGRPLDEIAKRYLQHILPHHDITREWAEFSVSTLQAPPATMKDAEEQASQTPAG 625
             |:....|.||                             ||:|     |:.|...:....|.:|
Mouse   877 -PSTSHSVKPQ-----------------------------SVTT-----ASRKTKAQNKQTTLSG 906

  Fly   626 RRK-SFTFVIPY-LNDRNHILVRRVVDRSEHLDRSFKEEPNKLQEFTFREMLPPQPDAEIVACAE 688
            |.| |:..::|| ::.:         .::.|:.:..|...|.|...:         |.::.
Mouse   907 RTKSSYKSILPYPVSPK---------QKNSHVSQGDKITKNSLSSTS---------DNQVT---- 949

  Fly   689 MISDMINTVAISCSENSFISEDPDALDASSVPKSSDLCPAKEETGKDTDKSGAKPKNLPNKQKRL 753
                  |.|..|..||:|             ||...|..|:::   ...:.|.:|..|...|.:|
Mouse   950 ------NLVVPSVDENAF-------------PKQISLRQAQQQ---HLQQQGTRPPGLSKSQVKL 992

  Fly   754 ANELRRLNATIIDAA-----------ARKADAN------------------------KPCSKDYC 783
            .:        :.|.|           ..:||.:                        .||:.|:|
Mouse   993 MD--------LEDCALWEGKPRTYITEERADVSLTTLLTAQASLKTKPIHTIIRKRAPPCNNDFC 1049

  Fly   784 HLGCICASLAGTELPVRD--HCGRAECVLDCRCLSAEESRV-----------------------M 823
            .|||:|:|||   |..|.  ||.|.:|:..|.||..:...|                       :
Mouse  1050 RLGCVCSSLA---LEKRQPAHCRRPDCMFGCTCLKRKVVLVKGGSKTKHFHKKAANRDPLFYDTL 1111

  Fly   824 RLEAADGRGISNEDAFNLRRKATAR--------------------LAKMEKDFTSTLVLTDNETL 868
            ..|..:|.|: .||...|:.|...:                    ..|:|.:.....|.....::
Mouse  1112 GEEGREGGGV-REDEEQLKEKKKRKKLEYTVCEAEPEQPVRHYPLWVKVEGEVDPEPVYIPTPSV 1175

  Fly   869 L------------INESQGDKKRRCTKAPKRYEDFDDSIYDEEEKDVV-----SPTT-------R 909
            :            ::.:...|.....|..:.|....:.:..||:||.|     |..|       .
Mouse  1176 IEPIKPLVLPQPDLSSTTKGKLTPGIKPARTYTPKPNPVIREEDKDPVYLYFESMMTCARVRVYE 1240

  Fly   910 KQKKHAAAAAAAAAAAAAAAAASAKISAPALSEPCFVKDTDLAK-LKHCFVGLRRLSNVENLATF 973
            ::|:.....:...:.:::....|:..|:|   |....|:.|..: ||.....|...|:...
Mouse  1241 RKKEEQRQLSPPLSPSSSFQQQSSCYSSP---ENRVTKELDSEQTLKQLICDLEDDSDKSQ---- 1298

  Fly   974 CMTHQLYKCFCG-GD----------SPDGKPVVI--------EKDQWNAPVTHFNPDLAVRAHYS 1019
               .:.:|..|. |:          ||.|...:|        |:|:        |..|::.:.:.
Mouse  1299 ---EKSWKSSCNEGESSSTSYVHQRSPGGPTKLIEIISDCNWEEDR--------NKILSILSQHI 1352

  Fly  1020 FERPPE---------ETSTKKKGK-EKKP-----KHKLESKSSNDVADQKPQTQAVETLPLKTES 1069
            ....|:         |.::::|.: ||.|     :.|:...||.| .|...:....||
Mouse  1353 NSNMPQSLKVGSFIIELASQRKCRGEKTPPVYSSRVKISMPSSQD-QDDMAEKSGSET------- 1409

  Fly  1070 KQEPPPANSLFKDESPLKRS---------------------NELNKIFNYFRSRPDVCRRAISIP 1113
             .:.|.:.....|.||::..                     :...|:..|.|.........|.:.
Mouse  1410 -PDGPLSPGKMDDISPVQTDALDSVRERLHGGKGLPFYAGLSPSGKLVAYKRKPSSTTSGLIQVN 1473

  Fly  1114 KNSYQR----LNQRRADRVRHQIAREESLKTNEM----LKMRIQGAVVYYRKEIDRQRKRELSKK 1170
            ..||.:    |.|..|   .|...|..:..|..:    |.:.....|:   .::....|...|:|
Mouse  1474 GKSYPQAKLLLGQMGA---LHPANRLAAYITGRLRPSVLDLSTLSTVI---SKVASNAKVAASRK 1532

  Fly  1171 PVIEVRNESDASDASVRQKKIETPAEGPT---PGKRIK--LKADEPPAQE------------KKA 1218
            |...:.:.|::..||          .||.   .||.:|  :.|..|.|..            .|.
Mouse  1533 PRTLLPSTSNSKMAS----------SGPATNRSGKNLKAFVPAKRPIAARPSPGGVFTQFVMSKV 1587

  Fly  1219 HMLDIQVPRIAA--------CYSLNTASVDVLAPDMAKE-----ATTSAAATGS----------- 1259
            ..|..::|.:..        .:|:..:.|.|:.|.::.|     :|.:||.|.|
Mouse  1588 GALQQKIPGVRTPQPLTGPQKFSIRPSPVMVVTPVVSSEQVQVCSTVAAAVTTSPQVFLENVTAV 1652

  Fly  1260 ----------THGSTDTNSANVCTFYNDVVKNMNTLVSKKMQDIDLALQRESKIIPSPNEEIL-- 1312
                      ...:|.::||:..........|..|||:.......:.|.:.:.|..||...:.
Mouse  1653 PSLTANSDMGAKEATYSSSASTAGVVEISETNNTTLVTSTQSTATVNLTKTTGITTSPVASVSFA 1717

  Fly  1313 --CIIKWTNFLAAFESGFVFIWDVQMKTHNFLAATTTNLMPSVCGAIAVVN----TKFAPD--PQ 1369
              .:...|..|....:....|..|.....:.:..|.|:.:.||...::.:|    ....|:  ||
Mouse  1718 KPLVASPTITLPVASTASTSIVMVTTAASSSVVTTPTSSLSSVPIILSGINGSPPVSQRPENAPQ 1782

  Fly  1370 ALPLMARMLMNSMRNEKTNRLAV-VMQG---------------RQSFWLVKG-----FLRHMQGN 1413
            ......::..|:::......|.: |.||               |.....|:|     ..||..|.
Mouse  1783 IPVTTPQISSNNVKRTGPRLLLIPVQQGSPTLRPIQNPQLQGQRMVLQPVRGPSGMNLFRHPNGQ 1847

  Fly  1414 AC----------TKPTPMTHPLLTKKINVLCSLLVKQRVRENEKKTLGDGSGAPYEVLA------ 1462
            ..          :...|...|::.:....:..:.:....:.:|..: ...|.:.:.|::
Mouse  1848 IVQLLPLHQIRGSNAQPSLQPVVFRNPGSMVGIRLPAPCKSSETPS-SSASSSAFSVMSPVIQAV 1911

  Fly  1463 ------GDVSPQTSLLMKNRSRDLKRKSQADERLLPSGPSMTKS--------SK--PSAGGYPI- 1510
                  ..:|...|||....|    ..|||....|...|..|::        ||  ||.||.|:
Mouse  1912 GSSPTVNVISQAPSLLSSGSS----FVSQAGTLTLRISPPETQNLASKTGSESKITPSTGGQPVG 1972

  Fly  1511 AASVATSTTSAFA-----------SSSGKSTPVCTAKTNSASTKNKSSATGIRSNIEFRK----- 1559
            .||:....:.:||           ||..:.......|..|.||..|.....|:...|.:|
Mouse  1973 TASLIPLQSGSFALLQLPGQKPIPSSVLQHVASLQIKKESQSTDQKDETNSIKREEETKKALPSK 2037

  Fly  1560 ----------------------VNHNDVD---ELQIPELHQTDHRWVVLDIFDDFSHI------- 1592
                                  .::|.:|   :|...|..:.|.|..... :...||.
Mouse  2038 DKALDSEANIMKQNSGIIASENTSNNSLDDGGDLLDEETLREDARPYEYS-YSTGSHTDEDKDGD 2101

  Fly  1593 ---------------FVPSFS------DMISLTRIHSVMQVAEERQKVVKLQFFPNA-------P 1629
                           .||...      |:::|..|.|:     ..||.||::..|..       |
Mouse  2102 EDSGNKNQNSPKEKQTVPEVRAGSKNIDIMALQSIRSI-----RPQKCVKVKVEPQEGSDNPENP 2161

  Fly  1630 YDAFVTPSSKK-------------------------------------KIYFGPLSLDMPPPVLV 1657
            .|..|.....|                                     |...|||:
Mouse  2162 DDFLVLSKDSKFELSGNQVKEQQSNSQAEAKKDCEDSLGKDSLRERWRKHLKGPLT--------- 2217

  Fly  1658 LLQSVDRKMMLREVYQREHSI-------PVQRHRR------------------------------ 1685
                 .:.:.:.:.:.:|.::       |.|.:..
Mouse  2218 -----QKYIGISQNFNKEANVQFFTEMKPCQENSEQDISELLGKSGTIESGGVLKTEDGSWSGIS 2277

  Fly  1686 -SMAFWVLQ------INGQVHFE---IDTESTAKLAAQQKNAIGTPPGLNVLKIPSQLSVEIEKN 1740
             |.||.::.      ..|..||:   :......|...|.|:...:.....||.:..: ..|.||.
Mouse  2278 SSAAFSIIPRRATKGRRGSRHFQGHLLLPREQMKPKQQTKDGRSSAADFTVLDLEDE-DEEDEKT 2341

  Fly  1741 QDEVPPVVVIDS--DEEDDDGERQLVIDE-QDDEQAETDVKQEVERTGFTIQTLPSSGALQITIS 1802
            .|.:..:|.:.|  ..|:.|.|:...:|. :||||.:.:..:|:..              :|...
Mouse  2342 DDSLDEIVDVVSGYQSEEVDVEKNNYVDYLEDDEQVDVETIEELSE--------------EINFP 2392

  Fly  1803 DSAETSSHPAKDVNTCHFSGGFMPFIANVPA--KFGETAPTTQFLTPQVQVTTSQSGP------- 1858
            ....|::|.......||         :::.|  |..|.:.....::.:::.......|
Mouse  2393 YKKTTATHTQSFKQQCH---------SHISADEKASEKSRKVSLISSKLKDDCWGDKPHKETEAF 2448

  Fly  1859 ----ETLTSSSSSHLPASKSAYPKINESLQELFSSGVPPGGITITKVDSQEKTLPNETVQVV--K 1917
                .|.|::........:..:.|:..:|..|.||.|.. .:.:.:..|:.:.|.::..:::  |
Mouse  2449 AYYRRTHTANERRRRGEMRDLFEKLKITLGLLHSSKVSK-SLILNRAFSEIQGLTDQADKLIGQK 2512

  Fly  1918 N----KKSIAITGIHKQVTKAASSTATVTAARAPVV--KPQSTSVSK-----------VAPPI-- 1963
            |    |:||.|    ::|:..:..|..|...:...:  |.|:....|           |:|.|
Mouse  2513 NLLSRKRSILI----RKVSSLSGKTEEVVLKKLEYIYAKQQALEAQKRKKKLGSDEFCVSPRIGT 2573

  Fly  1964 -RPGATTQPKTLVRLY-----PKPALAAGRKSLPANAKTPVATPRQSQPVACD--------KPPL 2014
             ..|::.....|.::.     .||.:.:.::.......:|..||..|..:...        |.||
Mouse  2574 QLEGSSASSVDLGQMLMNNRRGKPLILSRKRDQATENASPSDTPHSSANLVMTPQGQLLTLKGPL 2638

  Fly  2015 VSGSTL---PALVEPSARKSLPSKPLAAGEH----LRPR----QSLPA--------------KVT 2054
            .||..:   |||:|...:..:.|..::..|:    :.||    .||.|              :|.
Mouse  2639 FSGPVVAVSPALLEGGLKPQVASSTMSQSENDDLFMMPRIVNVTSLAAEEDLGGMSGNKYRHEVP 2703

  Fly  2055 ANPPAAARPDAASTSAQNLTNV-----------SKAQLAKEEICYGIMVAKDLPRFRAKVEGSDF 2108
            ...|.....|.|.:.|.:|.:.           |:..|...::   ::..||          |.|
Mouse  2704 DGKPLDHLRDIAGSEASSLKDTERISSRGNHRDSRKALGPTQV---LLANKD----------SGF 2755

  Fly  2109 MIKIPEHGVFRFKTFGLAASFLSRHVAKDPKLKQFLPAEWK---------------FHPLE 2154
                 .| |....|...|..|:.::::.|.:..::   :||               ||.|:
Mouse  2756 -----PH-VADVSTMQAAQEFIPKNMSGDVRGHRY---KWKECELRGERLKSKESQFHKLK 2807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ocm	NP_001188998.1	DUF4801	771..821	CDD:292677	22/75 (29%)
Mga	XP_006499750.1	TBOX	74..264	CDD:238106
		DUF4801	1038..1080	CDD:374336	18/44 (41%)
		DUF5585	<1510..>1811	CDD:375359	56/313 (18%)
		Atrophin-1	1729..>2023	CDD:367360	55/298 (18%)
		bHLHzip_MGA	2452..2516	CDD:381481	12/64 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831509
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830