DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ocm and Tbr1

DIOPT Version :9

Sequence 1:	NP_001188998.1	Gene:	ocm / 37874	FlyBaseID:	FBgn0266083	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_033348.2	Gene:	Tbr1 / 21375	MGIID:	107404	Length:	681	Species:	Mus musculus

Alignment Length:	762	Identity:	145/762 - (19%)
Similarity:	242/762 - (31%)	Gaps:	215/762 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1423 HPLLTKKINVLCSLLVKQRVR----ENEKKTLGDGSGAPYEVLAGDVSPQTSLLMKNR-SRDLKR 1482
            ||:::...|:..|..:|:..|    :::.....|...:|.:|....:||....:.:.| |.|
Mouse    37 HPIISTTDNLERSSPLKKITRGMTNQSDTDNFPDSKDSPGDVQRSKLSPVLDGVSELRHSFD--- 98

  Fly  1483 KSQADERLLPSGPSMTKSSKPSAGGYPIAASVATSTTSAFASSSGKSTPVCTAKTNSASTKNKSS 1547
            .|.||..||      ::||:|.      :|:.|.|....:.|..|.:.|..:..:.|....:...
Mouse    99 GSAADRYLL------SQSSQPQ------SAATAPSAMFPYPSQHGPAHPAFSIGSPSRYMAHHPV 151

  Fly  1548 ATGIRSNIEFRKVNHNDVDELQIPELHQTDHRWVVLDIFDDFSHI---FVPSFSDM--------I 1601
            .|....|......:.........|...|..|.:.... |..||..   .||..:.:        :
Mouse   152 ITNGAYNSLLSNSSPQGYPTAGYPYPQQYGHSYQGAP-FYQFSSTQPGLVPGKAQVYLCNRPLWL 215

  Fly  1602 SLTRIHSVMQVAEERQKVVKLQFF------PNAPYDAFV-------------------------- 1634
            ...|..:.|.:.::.:::.....|      |.|.|:.||
Mouse   216 KFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCGKADTN 280

  Fly  1635 -----------TPSS-----KKKIYFGPLSLDMPPPV------LVLLQSVDRKMMLREVYQREHS 1677
                       :|::     :::|.||.|.|......      :|:|||:
Mouse   281 VQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSL--------------- 330

  Fly  1678 IPVQRHRRSMAFWVLQINGQVHFEIDTESTAKLAAQQKNAIGTPPGLNVLKIPSQLSVEIEKNQD 1742
                 |:......|:::|     |..||.|::....|   ..|.|....:.:.:..:.:|.:.:.
Mouse   331 -----HKYQPRLHVVEVN-----EDGTEDTSQPGRVQ---TFTFPETQFIAVTAYQNTDITQLKI 382

  Fly  1743 EVPPVVVIDSDEEDD-----DGERQLVIDEQDDEQAETDVKQEVERTGFTIQTLPSSGALQITIS 1802
            :..|......|..|.     |.:| |.....|..:::..........|..:|....|...:....
Mouse   383 DHNPFAKGFRDNYDTIYTGCDMDR-LTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFH 446

  Fly  1803 DSAETSSHPAKDVNTCHFSGGFMPFIANVPAKFGETAPTTQFLTPQVQVTTSQSGPETLTSSSSS 1867
            ..|.....|..|.:..|.:|...|..|..|   |..:|...|:||                 :::
Mouse   447 PGAGAGPGPGTDRSVPHTNGLLSPQQAEDP---GAPSPQRWFVTP-----------------ANN 491

  Fly  1868 HLPASKSAYPKINESLQELFSSGVPPGGITITKVDSQEKTLPNETVQVVKNKKSIAITGIHKQVT 1932
            .|..:.|||.                   |.|.......||           .|.|..|:.....
Mouse   492 RLDFAASAYD-------------------TATDFAGNAATL-----------LSYAAAGVKALPL 526

  Fly  1933 KAASSTATVTAARAPVVKPQSTSVSKVAPPIRPGATTQPK-------TLVRLYPKPALAAGRKS- 1989
            :||..|.          :|    :...|.|...||.:.|:       :::..:|..|.||.|.:
Mouse   527 QAAGCTG----------RP----LGYYADPSGWGARSPPQYCGAKSGSVLPCWPNSAAAAARMAG 577

  Fly  1990 ----LPANAKTPVATPRQSQPVACD-KPPLVSGSTLPALVEPSARKSLPSKPLAAGEHLRPRQSL 2049
                |...|:...|......|.|.| ||..:|.|:.  :..||:.||:.|......|..:.|:..
Mouse   578 ANPYLGEEAEGLAAERSPLAPAAEDAKPKDLSDSSW--IETPSSIKSIDSSDSGIYEQAKRRRIS 640

  Fly  2050 PAKVTANPPAAARPDAASTSAQNLTNVSKAQLAKEEICYGIMVAKDL 2096
            ||..           ..|.|:..|.:...||...|:.|     |||:
Mouse   641 PADT-----------PVSESSSPLKSEVLAQRDCEKNC-----AKDI 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ocm	NP_001188998.1	DUF4801	771..821	CDD:292677
Tbr1	NP_033348.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..83		7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..127		6/24 (25%)
		TBOX	203..396	CDD:238106	31/220 (14%)
		T-box_assoc	418..679	CDD:374412	70/336 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..483		10/38 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..655		19/70 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831508
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830