DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nop60B and dkc1

DIOPT Version :9

Sequence 1:	NP_001014547.1	Gene:	Nop60B / 37873	FlyBaseID:	FBgn0259937	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_001028279.2	Gene:	dkc1 / 613144	ZFINID:	ZDB-GENE-031118-120	Length:	506	Species:	Danio rerio

Alignment Length:	514	Identity:	341/514 - (66%)
Similarity:	412/514 - (80%)	Gaps:	20/514 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADVEVRKEKKKKKIKEEPLDGDDIGTLQKQGNFQIKPSSKIAELDTSQWPLLLKNFDKLNIRSN 65
            |||.|.:||||:|..|   :..:::|.:|:.|:|.|||.||:|.|||||||||||||||||||:.
Zfish     1 MADTESKKEKKRKSKK---ISDEEVGDIQESGDFLIKPESKVASLDTSQWPLLLKNFDKLNIRTA 62

  Fly    66 HYTPLAHGSSPLNRDIKEYMKTGFINLDKPSNPSSHEVVAWIKKILKVEKTGHSGTLDPKVTGCL 130
            |||||.|||:||.|.|.:|:::||||||||:||||||||||||:||:||||||||||||||||||
Zfish    63 HYTPLPHGSNPLKRGIHDYVRSGFINLDKPANPSSHEVVAWIKRILRVEKTGHSGTLDPKVTGCL 127

  Fly   131 IVCIDRATRLVKSQQSAGKEYVAIFKLHGAVESVAKVRQGLEKLRGALFQRPPLISAVKRQLRVR 195
            |||::|||||||||||||||||.|.:||.|:|:..::.:.||.|.||||||||||:|||||||||
Zfish   128 IVCVERATRLVKSQQSAGKEYVGIVRLHNALENEHQLARALECLTGALFQRPPLIAAVKRQLRVR 192

  Fly   196 TVYDSKLLDYDETRNMGVFWVSCEAGSYIRTMCVHLGLVLGVGGQMLELRRVRSGIQSERDGMVT 260
            |:|:|||::||..|.:|:||||||||:||||:||||||:|||||||.||||||||:..|:|.:||
Zfish   193 TIYESKLIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVLGEKDNLVT 257

  Fly   261 MHDVLDAMWLYENHKDESMLRRVIKPLEGLLVNHKRIIMKDSSVNAVCYGAKITLPGVLRYEDGI 325
            |||||||.|.::::|||:.|||||.|||.||::||||:||||:|||:||||||.|||||||||||
Zfish   258 MHDVLDAQWQFDHNKDETYLRRVIFPLEKLLISHKRIVMKDSAVNAICYGAKIMLPGVLRYEDGI 322

  Fly   326 EIDQEIVICTTKGEAICLAIALMTTATMASCDHGVVAKIKRVIMERDTYPRKWGLGPKASAKKAL 390
            |::|:||:.||||||||.|:||||||.:::||||||||||||||||||||||||||||||.||.:
Zfish   323 EVNQDIVVITTKGEAICTAVALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKASQKKMM 387

  Fly   391 IAAGKLDKFGRPNENTPKEWLTGYVDYNAKKPAAQEVSPTNGSSEPSKRKLSTSSVEETAAAAV- 454
            |..|.|||.|:||.:||.:|..|||||:..|       ...|....:|||...|..|..||||.
Zfish   388 IQKGLLDKHGKPNNSTPSDWKEGYVDYSTTK-------VKKGGEASAKRKRDESGSEGEAAAAAQ 445

  Fly   455 ----SEETPSKDKKKKKKKHK---GDEEAPEA-AEEEAEPVEK-EKKKKKKKDKDRDRD 504
                :||...|:||||||:.|   .:|.|.|| ||||.|..|. :|||||||.|:.:.|
Zfish   446 DTSKTEEESKKEKKKKKKEKKQKLAEEAAAEAPAEEETEVTESAKKKKKKKKAKETEAD 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nop60B	NP_001014547.1	DKCLD	47..104	CDD:285330	44/56 (79%)
		CBF5	54..379	CDD:273073	246/324 (76%)
		PseudoU_synth_hDyskerin	86..268	CDD:211338	139/181 (77%)
		PUA	295..368	CDD:279774	57/72 (79%)
dkc1	NP_001028279.2	DKCLD	44..101	CDD:285330	44/56 (79%)
		CBF5	51..376	CDD:273073	246/324 (76%)
		PseudoU_synth_hDyskerin	83..265	CDD:211338	139/181 (77%)
		PUA	292..365	CDD:279774	57/72 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589986
Domainoid	1	1.000	185	1.000	Domainoid score	I3338
eggNOG	1	0.900	-	-		E1_COG0130
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1045
Inparanoid	1	1.050	679	1.000	Inparanoid score	I690
OMA	1	1.010	-	-		QHG54015
OrthoDB	1	1.010	-	-		D1070373at2759
OrthoFinder	1	1.000	-	-		FOG0005182
OrthoInspector	1	1.000	-	-		oto40273
orthoMCL	1	0.900	-	-		OOG6_100327
Panther	1	1.100	-	-	LDO	PTHR23127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R170
SonicParanoid	1	1.000	-	-		X3697
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800