DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nop60B and trub2

DIOPT Version :9

Sequence 1:	NP_001014547.1	Gene:	Nop60B / 37873	FlyBaseID:	FBgn0259937	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_001002200.2	Gene:	trub2 / 431747	ZFINID:	ZDB-GENE-040704-41	Length:	354	Species:	Danio rerio

Alignment Length:	222	Identity:	39/222 - (17%)
Similarity:	84/222 - (37%)	Gaps:	53/222 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 DKP--SNPSSHEVVAWIKKILKVEKTGHSGTLDPKVTGCLIVCIDRATRLVKS--QQSAGKEYVA 153
            |.|  :.|..|:|...:         ||  .||...:|.|::.:.:...::::  :....::|..
Zfish    83 DHPLVTGPQFHKVHVGV---------GH--RLDAFSSGVLVLGVGKGNSVLENLCKSHVTRDYTI 136

  Fly   154 IFKLHGAVESVAKVRQGLEK-----------------LRGALFQRPPLISAVKRQLRVRTVYD-- 199
            ..:...|.::.:...:.:||                 |:|:  .:..||:..:.:|:.:..|:
Zfish   137 EGEFGKATDNFSHTGRVIEKTTYDHITHDKLERVLAMLQGS--NQKALITYSQVELQTQEAYELA 199

  Fly   200 SKLLDYDETRNMGVFW---------------VSC--EAGSYIRTMCVHLGLVLGVGGQMLELRRV 247
            ::.|.|.:.::..:..               |.|  |...|:|.:...:||.|.......::||.
Zfish   200 ARGLLYPDGKSPPILTGLRCIKFNPPHFTLEVRCVNETQKYLRKLIHEVGLELRASAVCTKVRRT 264

  Fly   248 RSGIQSERDGMVTMHDVLDAMWLYENH 274
            |.|.....:.:...|...|::....||
Zfish   265 RDGPFKVENALTRQHWTADSVLQAINH 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nop60B	NP_001014547.1	DKCLD	47..104	CDD:285330	4/12 (33%)
		CBF5	54..379	CDD:273073	39/222 (18%)
		PseudoU_synth_hDyskerin	86..268	CDD:211338	37/214 (17%)
		PUA	295..368	CDD:279774
trub2	NP_001002200.2	PseudoU_synth_hTruB2_like	16..289	CDD:211345	37/218 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0130
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810