DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nop60B and TRUB2

DIOPT Version :9

Sequence 1:	NP_001014547.1	Gene:	Nop60B / 37873	FlyBaseID:	FBgn0259937	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_056494.1	Gene:	TRUB2 / 26995	HGNCID:	17170	Length:	331	Species:	Homo sapiens

Alignment Length:	199	Identity:	36/199 - (18%)
Similarity:	67/199 - (33%)	Gaps:	44/199 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 KTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSA--GKEYVAIFKLHGAVESVAK----------- 166
            |.|....||.:.:|.|::.:....||:....:|  .|:|.....|..|.:...:
Human    90 KVGVGHRLDAQASGVLVLGVGHGCRLLTDMYNAHLTKDYTVRGLLGKATDDFREDGRLVEKTTYD 154

  Fly   167 --VRQGLEKLRGAL--FQRPPLISAVKRQLRVRTVYDSKLLDYDETRN---MGVFWVSC------ 218
              .|:.|:::...:  ..:..|:......|:.:..|:..:.......|   |.:..:.|
Human   155 HVTREKLDRILAVIQGSHQKALVMYSNLDLKTQEAYEMAVRGLIRPMNKSPMLITGIRCLYFAPP 219

  Fly   219 ----------EAGSYIRTMCVHLGLVLGVGGQMLELRRVRSGIQSERDGMVTMHD-VLDAMWLYE 272
                      |....:|.:...:||.|.......::||.       |||..|:.. :|...|...
Human   220 EFLLEVQCMHETQKELRKLVHEIGLELKTTAVCTQVRRT-------RDGFFTLDSALLRTQWDLT 277

  Fly   273 NHKD 276
            |.:|
Human   278 NIQD 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nop60B	NP_001014547.1	DKCLD	47..104	CDD:285330
		CBF5	54..379	CDD:273073	36/199 (18%)
		PseudoU_synth_hDyskerin	86..268	CDD:211338	33/189 (17%)
		PUA	295..368	CDD:279774
TRUB2	NP_056494.1	PseudoU_synth_hTruB2_like	11..283	CDD:211345	36/199 (18%)
TRUB2	NP_056494.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..331
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0130
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810