DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nop60B and cbf5

DIOPT Version :9

Sequence 1:	NP_001014547.1	Gene:	Nop60B / 37873	FlyBaseID:	FBgn0259937	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_594878.1	Gene:	cbf5 / 2542481	PomBaseID:	SPAC29A4.04c	Length:	474	Species:	Schizosaccharomyces pombe

Alignment Length:	480	Identity:	293/480 - (61%)
Similarity:	368/480 - (76%)	Gaps:	27/480 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NFQIKP-SSKIAELDTSQWPLLLKNFDKLNIRSNHYTPLAHGSSPLNRDIKEYMKTGFINLDKPS 96
            :|.||| ::..:::||::|||||||||||.:|:.||||:..|::||.|.|.||:.:|.||||||:
pombe     9 DFMIKPEATSASKIDTAEWPLLLKNFDKLLVRTGHYTPIPCGNNPLKRPIAEYVSSGVINLDKPA 73

  Fly    97 NPSSHEVVAWIKKILKVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVAIFKLHGAV 161
            ||||||||||:||||:|||||||||||||||||||:|.||||||||||||||||||.:.:||.:|
pombe    74 NPSSHEVVAWVKKILRVEKTGHSGTLDPKVTGCLIICNDRATRLVKSQQSAGKEYVCVLRLHDSV 138

  Fly   162 ESVAKVRQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYDETRNMGVFWVSCEAGSYIRT 226
            |....|...:|.|.||||||||||||||||||:|::|:|||:::|..||:.|||.|||||:|:||
pombe   139 EGERNVASAIETLTGALFQRPPLISAVKRQLRIRSIYESKLIEFDNERNLAVFWASCEAGTYMRT 203

  Fly   227 MCVHLGLVLGVGGQMLELRRVRSGIQSERDGMVTMHDVLDAMWLYENHKDESMLRRVIKPLEGLL 291
            :||||||:|||||.|.||||||||..||.|.:|||||||||.|:|:|.:|||.|||||:|||.||
pombe   204 LCVHLGLLLGVGGHMQELRRVRSGCLSENDDIVTMHDVLDAQWIYDNTRDESYLRRVIRPLESLL 268

  Fly   292 VNHKRIIMKDSSVNAVCYGAKITLPGVLRYEDGIEIDQEIVICTTKGEAICLAIALMTTATMASC 356
            |.:|||::|||:|||:|||||:.:||:||||.|||:::|||:.|||||||.:.||.|:|..:::|
pombe   269 VGYKRIVVKDSAVNAICYGAKLMIPGLLRYEAGIEVNEEIVLITTKGEAIAVGIAQMSTVELSTC 333

  Fly   357 DHGVVAKIKRVIMERDTYPRKWGLGPKASAKKALIAAGKLDKFGRPNENTPKEWLTGYVDY---N 418
            |||||||:||.|||||.|||:|||||::..||.|...|||||:||||||||.:|...|:||   |
pombe   334 DHGVVAKVKRCIMERDVYPRRWGLGPQSMKKKTLKKEGKLDKYGRPNENTPADWSKSYIDYSDPN 398

  Fly   419 AK--KPA--AQEVSPT-----NGSSEPSKRKLSTSSVEETAAAAVSEETPSKDKKKKKKKHKGDE 474
            |:  |||  ....:||     ||..:..|||...||.::...||..||...|.:.||:||.|.:
pombe   399 AEVAKPAPVVAPAAPTVEAEVNGVEDSKKRKSVESSEKDEDEAAKKEEKRRKKEAKKEKKEKKE- 462

  Fly   475 EAPEAAEEEAEPVEKEKKKKKKKDK 499
                         :||||:||||.:
pombe   463 -------------KKEKKEKKKKSE 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nop60B	NP_001014547.1	DKCLD	47..104	CDD:285330	37/56 (66%)
		CBF5	54..379	CDD:273073	226/324 (70%)
		PseudoU_synth_hDyskerin	86..268	CDD:211338	134/181 (74%)
		PUA	295..368	CDD:279774	47/72 (65%)
cbf5	NP_594878.1	DKCLD	24..81	CDD:285330	37/56 (66%)
		CBF5	31..356	CDD:273073	226/324 (70%)
		PseudoU_synth_hDyskerin	63..245	CDD:211338	134/181 (74%)
		PUA	272..345	CDD:279774	47/72 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	181	1.000	Domainoid score	I805
eggNOG	1	0.900	-	-		E1_COG0130
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1045
Inparanoid	1	1.050	587	1.000	Inparanoid score	I163
OMA	1	1.010	-	-		QHG54015
OrthoFinder	1	1.000	-	-		FOG0005182
OrthoInspector	1	1.000	-	-		oto101604
orthoMCL	1	0.900	-	-		OOG6_100327
Panther	1	1.100	-	-	LDO	PTHR23127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R170
SonicParanoid	1	1.000	-	-		X3697
TreeFam	1	0.960	-	-
	14	13.860