DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nop60B and K01G5.5

DIOPT Version :9

Sequence 1:	NP_001014547.1	Gene:	Nop60B / 37873	FlyBaseID:	FBgn0259937	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_499370.1	Gene:	K01G5.5 / 176504	WormBaseID:	WBGene00010478	Length:	445	Species:	Caenorhabditis elegans

Alignment Length:	492	Identity:	290/492 - (58%)
Similarity:	354/492 - (71%)	Gaps:	49/492 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KKIKEEPLDGDDIGTLQKQGNFQIKPSSKIAELDTSQWPLLLKNFDKLNIRSNHYTPLAHGSSPL 77
            ||.|...|:|||:...|::|:||:..|::.|:||.|||||||||:||||:|:|||||...|.|||
Worm     3 KKDKRSKLEGDDLAEAQQKGSFQLPSSNETAKLDASQWPLLLKNYDKLNVRTNHYTPHVEGVSPL 67

  Fly    78 NRDIKEYMKTGFINLDKPSNPSSHEVVAWIKKILKVEKTGHSGTLDPKVTGCLIVCIDRATRLVK 142
            .||||.|:.:||.||||||||||||||:|||:||:.|||||||||||||:|||||||||.|||.|
Worm    68 KRDIKNYISSGFFNLDKPSNPSSHEVVSWIKRILRCEKTGHSGTLDPKVSGCLIVCIDRTTRLAK 132

  Fly   143 SQQSAGKEYVAIFKLHGAVESVAKVRQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYDE 207
            |||.|||||:.|||||..||...||:|.||||.||||||||||||||||||:||||::|.::||.
Worm   133 SQQGAGKEYICIFKLHEEVEDDRKVKQALEKLTGALFQRPPLISAVKRQLRIRTVYENKFIEYDP 197

  Fly   208 TRNMGVFWVSCEAGSYIRTMCVHLGLVLGVGGQMLELRRVRSGIQSERDGMVTMHDVLDAMWLYE 272
            .:.||:|...||:|:|:||:||||||:||.||||.||||.||||..|.:.||||||||||.:|.:
Worm   198 AQQMGIFNCICESGTYVRTICVHLGLILGCGGQMQELRRNRSGICDENENMVTMHDVLDAQYLLD 262

  Fly   273 NHKDESMLRRVIKPLEGLLVNHKRIIMKDSSVNAVCYGAKITLPGVLRYEDGIEIDQEIVICTTK 337
            ..||||.:|.:::|||.||..|||:::|||.:||:||||||.:||:|||:|.||:.:||||.:||
Worm   263 TQKDESYMRHIVRPLEALLTQHKRVVVKDSCINAICYGAKILIPGILRYDDDIEVGKEIVIMSTK 327

  Fly   338 GEAICLAIALMTTATMASCDHGVVAKIKRVIMERDTYPRKWGLGPKASAKKALIAAGKLDKFGRP 402
            |||||:|||.|.|:|:||.|||||||.||||||||.|.|||||||.||.||.::..|.|||||:|
Worm   328 GEAICIAIAQMNTSTIASVDHGVVAKSKRVIMERDVYGRKWGLGPVASKKKQMVKDGLLDKFGKP 392

  Fly   403 NENTPKEWLTGYVDYNAKKPAAQEVSPTNGSSEPSKRKLSTSSVEETAAAAVSEETPSKDKKKKK 467
            |:.|||.|...||                                         :|.:|.:.||
Worm   393 NDTTPKSWAKEYV-----------------------------------------QTSTKKEVKK- 415

  Fly   468 KKHKGDEEAPEAAEEEAEPVEKEKKKKKKKDKDRDRD 504
                  ||.|:..|||| |.:|.||.||::..|.|.|
Worm   416 ------EETPDEEEEEA-PKKKSKKSKKQESSDSDSD 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nop60B	NP_001014547.1	DKCLD	47..104	CDD:285330	42/56 (75%)
		CBF5	54..379	CDD:273073	226/324 (70%)
		PseudoU_synth_hDyskerin	86..268	CDD:211338	133/181 (73%)
		PUA	295..368	CDD:279774	49/72 (68%)
K01G5.5	NP_499370.1	DKCLD	38..94	CDD:285330	42/55 (76%)
		CBF5	44..369	CDD:273073	226/324 (70%)
		PseudoU_synth_hDyskerin	76..258	CDD:211338	133/181 (73%)
		PUA	285..358	CDD:279774	49/72 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163600
Domainoid	1	1.000	156	1.000	Domainoid score	I2580
eggNOG	1	0.900	-	-		E1_COG0130
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1045
Inparanoid	1	1.050	587	1.000	Inparanoid score	I543
Isobase	1	0.950	-	0.906565	Normalized mean entropy	S134
OMA	1	1.010	-	-		QHG54015
OrthoDB	1	1.010	-	-		D1070373at2759
OrthoFinder	1	1.000	-	-		FOG0005182
OrthoInspector	1	1.000	-	-		oto19520
orthoMCL	1	0.900	-	-		OOG6_100327
Panther	1	1.100	-	-	LDO	PTHR23127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R170
SonicParanoid	1	1.000	-	-		X3697
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790