Protein Alignment Nop60B and DKC1

DIOPT Version :10

• Sequence 1: NP_525120.1
• Gene: Nop60B / 37873
• FlyBaseID: FBgn0259937
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_001354.1
• Gene: DKC1 / 1736
• HGNCID: 2890
• Length: 514
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 340/518 - (65%)
• Similarity: 409/518 - (78%)
• Gaps: 28/518 - (5%)

  Fly     1 MADVEV----RKEKKKKKIKEEPLDGDDIGTLQKQGNFQIKPSSKIAELDTSQWPLLLKNFDKLN 61
            |||.||    :|.||||:.|..|  .:|:..:|....|.|||.||:|:|||||||||||||||||
Human     1 MADAEVIILPKKHKKKKERKSLP--EEDVAEIQHAEEFLIKPESKVAKLDTSQWPLLLKNFDKLN 63

  Fly    62 IRSNHYTPLAHGSSPLNRDIKEYMKTGFINLDKPSNPSSHEVVAWIKKILKVEKTGHSGTLDPKV 126
            :|:.||||||.||:||.|:|.:|::|||||||||||||||||||||::||:||||||||||||||
Human    64 VRTTHYTPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKV 128

  Fly   127 TGCLIVCIDRATRLVKSQQSAGKEYVAIFKLHGAVESVAKVRQGLEKLRGALFQRPPLISAVKRQ 191
            ||||||||:|||||||||||||||||.|.:||.|:|...::.:.||.|.||||||||||:|||||
Human   129 TGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQ 193

  Fly   192 LRVRTVYDSKLLDYDETRNMGVFWVSCEAGSYIRTMCVHLGLVLGVGGQMLELRRVRSGIQSERD 256
            |||||:|:||:::||..|.:|:||||||||:||||:||||||:|||||||.||||||||:.||:|
Human   194 LRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKD 258

  Fly   257 GMVTMHDVLDAMWLYENHKDESMLRRVIKPLEGLLVNHKRIIMKDSSVNAVCYGAKITLPGVLRY 321
            .||||||||||.|||:||||||.||||:.|||.||.:|||::||||:|||:||||||.|||||||
Human   259 HMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRY 323

  Fly   322 EDGIEIDQEIVICTTKGEAICLAIALMTTATMASCDHGVVAKIKRVIMERDTYPRKWGLGPKASA 386
            |||||::||||:.||||||||:||||||||.:::||||:|||||||||||||||||||||||||.
Human   324 EDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQ 388

  Fly   387 KKALIAAGKLDKFGRPNENTPKEWLTGYVDY--NAKKPAAQEV--SP--TNGSSEPSKRKLSTSS 445
            ||.:|..|.|||.|:|.::||..|...||||  :|||....||  :|  ...:::.:|||..:.|
Human   389 KKLMIKQGLLDKHGKPTDSTPATWKQEYVDYSESAKKEVVAEVVKAPQVVAEAAKTAKRKRESES 453

  Fly   446 VEETAAAAVSEETPSKDK---KKKKKKHKGDEEAPEAAEEEAEPVE-----KEKKKKKKKDKD 500
                    .|:|||....   ||:|||.|.|::|....|..|||.:     .:|||||||.|:
Human   454 --------ESDETPPAAPQLIKKEKKKSKKDKKAKAGLESGAEPGDGDSDTTKKKKKKKKAKE 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nop60B	NP_525120.1	CBF5	54..379	CDD:273073	252/324 (78%)
DKC1	NP_001354.1	Nucleolar localization	2..21		9/18 (50%)
		CBF5	56..381	CDD:273073	252/324 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..514		28/74 (38%)
		Nuclear and nucleolar localization	446..514		28/71 (39%)