DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nop60B and Dkc1

DIOPT Version :9

Sequence 1:	NP_001014547.1	Gene:	Nop60B / 37873	FlyBaseID:	FBgn0259937	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_596910.1	Gene:	Dkc1 / 170944	RGDID:	621780	Length:	509	Species:	Rattus norvegicus

Alignment Length:	516	Identity:	334/516 - (64%)
Similarity:	402/516 - (77%)	Gaps:	21/516 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADVEV-----RKEKKKKKIKEEPLDGDDIGTLQKQGNFQIKPSSKIAELDTSQWPLLLKNFDKL 60
            |||.|.     :|.||||:.|  ||...|:..:|...:|.|||.||.|:||||||||||||||:|
  Rat     1 MADAEAAMTFPKKHKKKKERK--PLPEADVAEIQHAEDFLIKPESKAAQLDTSQWPLLLKNFDRL 63

  Fly    61 NIRSNHYTPLAHGSSPLNRDIKEYMKTGFINLDKPSNPSSHEVVAWIKKILKVEKTGHSGTLDPK 125
            |:|:.||||:..||:||.|:|.||::|||||||||||||||||||||::||:|||||||||||||
  Rat    64 NVRTTHYTPIPCGSNPLKREIGEYVRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPK 128

  Fly   126 VTGCLIVCIDRATRLVKSQQSAGKEYVAIFKLHGAVESVAKVRQGLEKLRGALFQRPPLISAVKR 190
            |||||||||:|||||||||||||||||.:.:||.|:|..|::.:.||.|.||||||||||:||||
  Rat   129 VTGCLIVCIERATRLVKSQQSAGKEYVGVVRLHNAIEGTAQLSRALETLTGALFQRPPLIAAVKR 193

  Fly   191 QLRVRTVYDSKLLDYDETRNMGVFWVSCEAGSYIRTMCVHLGLVLGVGGQMLELRRVRSGIQSER 255
            ||||||:|:|::::||..|.:||||||||||:||||:||||||:|||||||.||||||||:..||
  Rat   194 QLRVRTIYESRVVEYDPERRLGVFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVVGER 258

  Fly   256 DGMVTMHDVLDAMWLYENHKDESMLRRVIKPLEGLLVNHKRIIMKDSSVNAVCYGAKITLPGVLR 320
            |.||||||||||.:||::|:|||.||||:.|||.||.:|||::||||:|||:||||||.|||:||
  Rat   259 DHMVTMHDVLDAQYLYDHHRDESYLRRVVFPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLR 323

  Fly   321 YEDGIEIDQEIVICTTKGEAICLAIALMTTATMASCDHGVVAKIKRVIMERDTYPRKWGLGPKAS 385
            ||||||::||:|:.||||||:|:||||||||.:::||||||||||||||||||||||||||||||
  Rat   324 YEDGIEVNQEVVVITTKGEAVCVAIALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKAS 388

  Fly   386 AKKALIAAGKLDKFGRPNENTPKEWLTGYVDY--NAKKPAAQEVSPTNGSSEPS----KRKLSTS 444
            .||.||..|.|||.|||.:.||..|...||||  ::||..|.|.:|..|.:..:    |||..:.
  Rat   389 QKKQLIKQGLLDKHGRPTDGTPASWTRDYVDYSDSSKKATAAEATPGPGVTADAASIVKRKRDSD 453

  Fly   445 SVEETAAAAVSEETPSKDKKKKKKKHKGDEEAPEAAEEEAEPVEKEKKKKKKKDKDRDRDE 505
            |   .|..|....||...|:|||||.|.|     ..||.||..:.:..:||||.|.|..:|
  Rat   454 S---DADEATPTTTPRVKKEKKKKKEKAD-----GGEEAAEDGDGDATRKKKKKKARAAEE 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nop60B	NP_001014547.1	DKCLD	47..104	CDD:285330	43/56 (77%)
		CBF5	54..379	CDD:273073	245/324 (76%)
		PseudoU_synth_hDyskerin	86..268	CDD:211338	142/181 (78%)
		PUA	295..368	CDD:279774	55/72 (76%)
Dkc1	NP_596910.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		12/25 (48%)
		Nucleolar localization. /evidence=ECO:0000250	2..22		9/21 (43%)
		DKCLD	50..107	CDD:285330	43/56 (77%)
		CBF5	57..382	CDD:273073	245/324 (76%)
		PseudoU_synth_hDyskerin	89..271	CDD:211338	142/181 (78%)
		PUA	298..371	CDD:279774	55/72 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..509		59/134 (44%)
		Nuclear and nucleolar localization. /evidence=ECO:0000250	447..509		27/68 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348829
Domainoid	1	1.000	186	1.000	Domainoid score	I3284
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1045
Inparanoid	1	1.050	659	1.000	Inparanoid score	I738
OMA	1	1.010	-	-		QHG54015
OrthoDB	1	1.010	-	-		D1070373at2759
OrthoFinder	1	1.000	-	-		FOG0005182
OrthoInspector	1	1.000	-	-		oto97752
orthoMCL	1	0.900	-	-		OOG6_100327
Panther	1	1.100	-	-	LDO	PTHR23127
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3697
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910