Protein Alignment Nop60B and Dkc1

DIOPT Version :10

• Sequence 1: NP_525120.1
• Gene: Nop60B / 37873
• FlyBaseID: FBgn0259937
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_596910.1
• Gene: Dkc1 / 170944
• RGDID: 621780
• Length: 509
• Species: Rattus norvegicus
• Alignment Length: 516
• Identity: 334/516 - (64%)
• Similarity: 402/516 - (77%)
• Gaps: 21/516 - (4%)

  Fly     1 MADVEV-----RKEKKKKKIKEEPLDGDDIGTLQKQGNFQIKPSSKIAELDTSQWPLLLKNFDKL 60
            |||.|.     :|.||||:.|  ||...|:..:|...:|.|||.||.|:||||||||||||||:|
  Rat     1 MADAEAAMTFPKKHKKKKERK--PLPEADVAEIQHAEDFLIKPESKAAQLDTSQWPLLLKNFDRL 63

  Fly    61 NIRSNHYTPLAHGSSPLNRDIKEYMKTGFINLDKPSNPSSHEVVAWIKKILKVEKTGHSGTLDPK 125
            |:|:.||||:..||:||.|:|.||::|||||||||||||||||||||::||:|||||||||||||
  Rat    64 NVRTTHYTPIPCGSNPLKREIGEYVRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPK 128

  Fly   126 VTGCLIVCIDRATRLVKSQQSAGKEYVAIFKLHGAVESVAKVRQGLEKLRGALFQRPPLISAVKR 190
            |||||||||:|||||||||||||||||.:.:||.|:|..|::.:.||.|.||||||||||:||||
  Rat   129 VTGCLIVCIERATRLVKSQQSAGKEYVGVVRLHNAIEGTAQLSRALETLTGALFQRPPLIAAVKR 193

  Fly   191 QLRVRTVYDSKLLDYDETRNMGVFWVSCEAGSYIRTMCVHLGLVLGVGGQMLELRRVRSGIQSER 255
            ||||||:|:|::::||..|.:||||||||||:||||:||||||:|||||||.||||||||:..||
  Rat   194 QLRVRTIYESRVVEYDPERRLGVFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVVGER 258

  Fly   256 DGMVTMHDVLDAMWLYENHKDESMLRRVIKPLEGLLVNHKRIIMKDSSVNAVCYGAKITLPGVLR 320
            |.||||||||||.:||::|:|||.||||:.|||.||.:|||::||||:|||:||||||.|||:||
  Rat   259 DHMVTMHDVLDAQYLYDHHRDESYLRRVVFPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLR 323

  Fly   321 YEDGIEIDQEIVICTTKGEAICLAIALMTTATMASCDHGVVAKIKRVIMERDTYPRKWGLGPKAS 385
            ||||||::||:|:.||||||:|:||||||||.:::||||||||||||||||||||||||||||||
  Rat   324 YEDGIEVNQEVVVITTKGEAVCVAIALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKAS 388

  Fly   386 AKKALIAAGKLDKFGRPNENTPKEWLTGYVDY--NAKKPAAQEVSPTNGSSEPS----KRKLSTS 444
            .||.||..|.|||.|||.:.||..|...||||  ::||..|.|.:|..|.:..:    |||..:.
  Rat   389 QKKQLIKQGLLDKHGRPTDGTPASWTRDYVDYSDSSKKATAAEATPGPGVTADAASIVKRKRDSD 453

  Fly   445 SVEETAAAAVSEETPSKDKKKKKKKHKGDEEAPEAAEEEAEPVEKEKKKKKKKDKDRDRDE 505
            |   .|..|....||...|:|||||.|.|     ..||.||..:.:..:||||.|.|..:|
  Rat   454 S---DADEATPTTTPRVKKEKKKKKEKAD-----GGEEAAEDGDGDATRKKKKKKARAAEE 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nop60B	NP_525120.1	CBF5	54..379	CDD:273073	245/324 (76%)
Dkc1	NP_596910.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		12/25 (48%)
		Nucleolar localization. /evidence=ECO:0000250	2..22		9/21 (43%)
		CBF5	57..382	CDD:273073	245/324 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	381..509		59/134 (44%)
		Nuclear and nucleolar localization. /evidence=ECO:0000250	447..509		27/68 (40%)