DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nop60B and TRUB1

DIOPT Version :9

Sequence 1:	NP_001014547.1	Gene:	Nop60B / 37873	FlyBaseID:	FBgn0259937	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_631908.1	Gene:	TRUB1 / 142940	HGNCID:	16060	Length:	349	Species:	Homo sapiens

Alignment Length:	218	Identity:	59/218 - (27%)
Similarity:	86/218 - (39%)	Gaps:	59/218 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 TGFINLDKPSNPSSHEVV----------------AWIKKILKVEKTGHSGTLDPKVTGCLIVCID 135
            :|...:.||..|:|.|::                .|.|:..:..|.||.||||....|.|:|.|.
Human    69 SGVFAVHKPKGPTSAELLNRLKEKLLAEAGMPSPEWTKRKKQTLKIGHGGTLDSAARGVLVVGIG 133

  Fly   136 RATRLVKSQQSAGKEYVAIFKLHGAVESV------------AKVRQG-----LEKLRGALFQRPP 183
            ..|:::.|..|..|.|.||.:|..|.:::            .|:.|.     |:|..|.:.|.||
Human   134 SGTKMLTSMLSGSKRYTAIGELGKATDTLDSTGRVTEEKPYDKITQEDIEGILQKFTGNIMQVPP 198

  Fly   184 LISAVKRQ------------------LRVRTVYDSKLLDYDETRNMGVFW---VSCEAGSYIRTM 227
            |.||:|:.                  .|..|||...|..:...     |:   |.|..|.|||::
Human   199 LYSALKKDGQRLSTLMKRGEVVEAKPARPVTVYSISLQKFQPP-----FFTLDVECGGGFYIRSL 258

  Fly   228 CVHLGLVLGVGGQMLELRRVRSG 250
            ...:|..|.....:|||.|.:.|
Human   259 VSDIGKELSSCANVLELTRTKQG 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nop60B	NP_001014547.1	DKCLD	47..104	CDD:285330	6/16 (38%)
		CBF5	54..379	CDD:273073	59/218 (27%)
		PseudoU_synth_hDyskerin	86..268	CDD:211338	59/218 (27%)
		PUA	295..368	CDD:279774
TRUB1	NP_631908.1	PseudoU_synth_TruB_4	70..348	CDD:211344	59/217 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0130
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100327
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710