Protein Alignment CG3328 and MYRF

DIOPT Version :10

• Sequence 1: NP_611893.3
• Gene: CG3328 / 37871
• FlyBaseID: FBgn0034985
• Length: 1423
• Species: Drosophila melanogaster
• Sequence 2: XP_005274279.1
• Gene: MYRF / 745
• HGNCID: 1181
• Length: 1152
• Species: Homo sapiens
• Alignment Length: 1503
• Identity: 432/1503 - (28%)
• Similarity: 592/1503 - (39%)
• Gaps: 458/1503 - (30%)

  Fly     1 MDLDFFE--LSPQDLDDI---------NSDGMDHLDLLVQGAFDDGIQLGHNGHLS-AGGGVHSH 53
            :|....|  :|.:|..|:         :|....|....:.|:  .|:.     ||| .|||....
Human    28 IDTSILEEYISKEDASDLCFPDISAPASSASYSHGQPAMPGS--SGVH-----HLSPPGGGPSPG 85

  Fly    54 MESPHTSPMNGLDAHLTNSGRVGST----------PVAAQAQSHVHP-QLPESPPDS-QPAYSP- 105
            ...|...|..|...:..|:..:|:.          |:.|:.::...| .||:||||| ..||||
Human    86 RHGPLPPPGYGTPLNCNNNNGMGAAPKPFPGGTGPPIKAEPKAPYAPGTLPDSPPDSGSEAYSPQ 150

  Fly   106 -LGEAHGMAMPLQRELIYPGLAPMQHQANMLQTDLGQYASPPQQQHHFAAPQADVRIKHESELII 169
             :.|.|.:.......|.:.|:.............|.....||....|:...|.|:.:|.|..  |
Human   151 QVNEPHLLRTITPETLCHVGVPSRLEHPPPPPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPP--I 213

  Fly   170 NPSNLLGQQQPQQQQMQQQQQQLNEQMFAQH-------------HQQHQDSILQDQMLYYDNGAG 221
            .....:||..........||.|:..|:..||             |.:...|.|..|||
Human   214 PHYAAMGQGLVPTDLHHTQQSQMLHQLLQQHGAELPTHPSKKRKHSESPPSTLNAQML------- 271

  Fly   222 AGMYATGSYQNLSTCTLTSALGLGDRVQVIGT-SQLSLNRVSAPSTPVHSLSRKRKMSTQLDCPE 285
            .||..                      |..|| :.|.|:...|||.|..              |:
Human   272 NGMIK----------------------QEPGTVTALPLHPTRAPSPPWP--------------PQ 300

  Fly   286 FPSAPKVDAGLQMSPLRASHHSLATPTPAPSHCSASVSPALSAVNSQADNSLDGQPGGVVTGSGS 350
            .|.:|    |....||     |:|.....|.|...:.||                  |::..|.|
Human   301 GPLSP----GPGSLPL-----SIARVQTPPWHPPGAPSP------------------GLLQDSDS 338

  Fly   351 GSGSGSGSGSEAGDPAGGQCIRFNAFQPENWHKLFDQSLQELSVIYYRVDADKGFNFSVSDDAYV 415
            .|||..       || ..|.|::...|...|..|:|.:.:||.::.|||||||||||||.|||:|
Human   339 LSGSYL-------DP-NYQSIKWQPHQQNKWATLYDANYKELPMLTYRVDADKGFNFSVGDDAFV 395

  Fly   416 CQKKNHFQVTCHARLQGDAKFVKTPSGFEKIKSFHLHFYGVKFEAPNQTIRVEQSQSDRSKKAFH 480
            ||||||||||.:..:.|:.|:||||.|.:.:..|:|..:|||.||.||:|.:|||||||||:.|:
Human   396 CQKKNHFQVTVYIGMLGEPKYVKTPEGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFN 460

  Fly   481 PVPIDLQKHIVSKITVGRLHFSETTNNNMRKKGRPNPEQRFFQLVVGLHVHTISGNFPVVSHGSE 545
            ||.::|....|:|:|||||||||||.|||||||:|||:||:|.|||.|..|..:.|:.:.:..||
Human   461 PVTVNLPPEQVTKVTVGRLHFSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISE 525

  Fly   546 KIIVRASNPGQFESDVDLCWQRGLTPESVFHTGRVGINTDRPDESLVVHGNLKVSGHIVQPSDSR 610
            :||||||||||||||.|:.|||...|::|||.||||||||||||:||||||:||.|.::.|||.|
Human   526 RIIVRASNPGQFESDSDVLWQRAQVPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLR 590

  Fly   611 AKQEIGELDTSVQLRNLQKIRIVRYRYMPEFAVHSGLRRESDTREIEDTGVIAQEVREVIPDAVQ 675
            ||:.:.|:||:.||:.:.::|:|.|||.||||..:|:...:     .:||||||||:|::|:||:
Human   591 AKEHVQEVDTTEQLKRISRMRLVHYRYKPEFAASAGIEATA-----PETGVIAQEVKEILPEAVK 650

  Fly   676 EAGSVVLPNGNVIEKFLLVNKDRILMENIGAVKELCKVTCSLETRIEHLERANIGQNSQQLRAKD 740
            :.|.:|..||..||.||:|||:||.|||:||||||||:|.:|||||:.|||.:  ....:||..|
Human   651 DTGDMVFANGKTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWS--HKLAKLRRLD 713

  Fly   741 LLE---------------------PRCILPERAAITSYGSRRDGYEVC-SSRSLQIVIFLLIIVM 783
            .|:                     |....|.:.|..|.....|  :.| |.|.||..|..|::||
Human   714 SLKSTGSSGAFSHAGSQFSRAGSVPHKKRPPKVASKSSSVVPD--QACISQRFLQGTIIALVVVM 776

  Fly   784 AACLAAVSTLYFVEHNKQQ---QADGFFGAGMFRQEAGPTHLSDEERHYFHNLHTLFKNKTHGPW 845
            |..:.::||||.:....::   ..||.|
Human   777 AFSVVSMSTLYVLSLRTEEDLVDTDGSF------------------------------------- 804

  Fly   846 PMRQMYATSTSRPPGSRQAEEEAEDLAAVLTKPQVSSGQQQLSLKHGVITTTAPRFSNKTISSKK 910
                  |.|||              ....|.:||...|.:.|          .|..|:::..:
Human   805 ------AVSTS--------------CLLALLRPQPPGGSEAL----------CPCRSSQSFGT-- 837

  Fly   911 GKWPPTQEVLRQAAGQKLHLPQPVHVVPAAPAKVPPAALNDTVASTEKPPQAIPLPQDFENNSID 975
                 ||  |||:.           :....|...|...|..|..::..|..|:        .::|
Human   838 -----TQ--LRQSP-----------LTTGLPGIQPSLLLVTTSLTSSAPGSAV--------RTLD 876

  Fly   976 IDAQQKQSQLKLDEHIVVVGTIASPASDAYDSNSPSVAAHPIRKFNPGTVYTHVYKTVSPPTANL 1040
            :          ...|...|...:||.::  .:..||:..    .||||    ||......|:.|
Human   877 M----------CSSHPCPVICCSSPTTN--PTTGPSLGP----SFNPG----HVLSPSPSPSTN- 920

  Fly  1041 ALTTNKVSTEPAQSPLTHALDVPPPALPVRNSSDNPDALDLQNLSNTNESVDNPITQVFGFEYQE 1105
                   .:.|:|..|          |||.|                             ...:.
Human   921 -------RSGPSQMAL----------LPVTN-----------------------------IRAKS 939

  Fly  1106 SGLRESNLGRRSANQRSLEWIRQKDIKTAIFGQPAECNGDESVSDNCQSVCFEELPPTHPQPDNV 1170
            .||..:.:| .|.:.:|||.:..                                 |..|.|
Human   940 WGLSVNGIG-HSKHHKSLEPLAS---------------------------------PAVPFP--- 967

  Fly  1171 DANVKEQHVEDDLQSAEEQEHDPDIVETQPAVSIGNETSAALEAQPGFLGKSSHGTDALTKKQTE 1235
                                              |.:..|......||.|::..|....:....|
Human   968 ----------------------------------GGQGKAKNSPSLGFHGRARRGALQSSVGPAE 998

  Fly  1236 PVVAAKDDPVYRLLQSASGQDQGPKADESVLPPFQLDCWSVASCVLAAQYNHTIDVEQFCPTSGS 1300
            |..|                 ||..|.....|...|....|..       |......|:|....:
Human   999 PTWA-----------------QGQSASLLAEPVPSLTSIQVLE-------NSMSITSQYCAPGDA 1039

  Fly  1301 SL--NVSYVVPVSRYLQASSLELHLS------SNKPLQWSICVDEDQAKPSANGQLNED----DE 1353
            ..  |.:|.:|||     |...||||      |:.|:...:|....:.:|...|.|.:.    .:
Human  1040 CRPGNFTYHIPVS-----SGTPLHLSLTLQMNSSSPVSVVLCSLRSKEEPCEEGSLPQSLHTHQD 1099

  Fly  1354 AESTS---GVKILKQQGKNKLSLALDLPARGYFLREFMLRASHDLEQQKLCDDNAHPANPILQYN 1415
            .:.||   .:.||.                   .|||.......|..|..|...| .|.|...|:
Human  1100 TQGTSHRWPITILS-------------------FREFTYHFRVALLGQANCSSEA-LAQPATDYH 1144

  Fly  1416 FRIVRDCD 1423
            |...|.||
Human  1145 FHFYRLCD 1152

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3328	NP_611893.3	NDT80_PhoG	413..560	CDD:398753	88/146 (60%)
		Peptidase_S74_CIMCD	607..729	CDD:381748	65/121 (54%)
MYRF	XP_005274279.1	NDT80_PhoG	393..540	CDD:398753	88/146 (60%)
		Peptidase_S74_CIMCD	587..705	CDD:381748	65/124 (52%)
		MRF_C2	1017..1151	CDD:464020	37/165 (22%)