DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Naa35 and Naa35

DIOPT Version :9

Sequence 1:	NP_611891.1	Gene:	Naa35 / 37866	FlyBaseID:	FBgn0034982	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_030103327.1	Gene:	Naa35 / 78689	MGIID:	1925939	Length:	840	Species:	Mus musculus

Alignment Length:	815	Identity:	302/815 - (37%)
Similarity:	442/815 - (54%)	Gaps:	110/815 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PAEADP----STMNGSSVAEPPDFQAATAAAAAAARASSL-----------------EQDEWSVG 50
            ||...|    |.....|||..|.: |..:|.|.|.|..:|                 :...|.:|
Mouse    97 PAAGSPRGPVSASISVSVALGPRW-ARVSAEAPAGRGKALVLRSPPGIMVMKATVDDDASGWELG 160

  Fly    51 ECGFLDPDVQRTMRSGSAAEDITQYPMHGWVDVTKEFHDACAELQPGELAQDMLFGLFEAMSAIE 115
                    |...|...|.:          |||:|::|.|||.||:.|||..|.||||||||||||
Mouse   161 --------VPEKMEKSSTS----------WVDITQDFEDACRELKLGELLHDKLFGLFEAMSAIE 207

  Fly   116 IMDPKMDVGMGFDKQDLPPPSFEAAIATGAIKLDDLTPSELIGIYDALFSCLVSWLEGNSMDQVL 180
            :||||||.||..::.:....:||.||..|.||:.||:..|||||.|..|.||::||||:|:.|.:
Mouse   208 MMDPKMDAGMIGNQVNRKVLNFEQAIKDGTIKIKDLSLPELIGIMDTCFCCLITWLEGHSLAQTV 272

  Fly   181 FTCLYLHAPAQIKDKALRVFCTAVRNLIVVIKKIIAVAAVNEEEDFQ--LYGNSALLAAEKAQPA 243
            |||||:|.|..|:|.|::.|...:..:..:.::.:..|||.||||||  .||   ...|......
Mouse   273 FTCLYIHNPDFIEDPAMKAFALGILKICDIAREKVNKAAVFEEEDFQSMTYG---FKMANSVTDL 334

  Fly   244 TVYSSLKDVEDELIRKCKKLTSTEDWMAVVHRLRFMRHLFQVIYHVEQMASNDTVDDKVDI---- 304
            .|...||||||:|.|:.|...|.:                           .:..|.:|::
Mouse   335 RVTGMLKDVEDDLQRRVKSTRSRQ---------------------------GEERDPEVELETSA 372

  Fly   305 ----YKILLVASEMLPGIRNTLDRGTQPEKGS---DAPNPMGFSPRIHDRSQPPAFPRSIKIRDR 362
                .|:::.|:::|..|..:|..|.|.:.|:   |.|..|||.|.::.|..||.|||..||..|
Mouse   373 VAEAQKLMVQAADLLSAIHTSLHHGIQAQNGTTKGDHPIMMGFEPLVNQRLLPPTFPRYAKIIKR 437

  Fly   363 PSSYQFLEEMISRFKYACKVTKYKDYYSALNFFIEYSKKSGQCILSRSVLQTLFSANMRMAHGKL 427
            .....:...:|.|.|..|:|....:.:..|:||.|:|::| .|:||||:|||.|..:.:...|..
Mouse   438 EEMVNYFSRLIDRIKTVCEVVNLPNLHCILDFFCEFSEQS-PCVLSRSLLQTTFLVDNKKVFGTH 501

  Fly   428 PMKQFLRHSVQVFNSPPVLNAKHPVAADPKVQQHLENFFRYCINMNTFTQFIRICGFNRARQRDK 492
            .|:..::.:::.|.|||||:.|..:..:.:.:..:::|..:|:  ..|...::|.|.||||||||
Mouse   502 LMQDMVKDALRSFVSPPVLSPKCCLYNNHQAKDCIDSFVTHCV--RPFCSLVQIHGHNRARQRDK 564

  Fly   493 LARLIENFDTIQVDAARLDSMMNQLANERAMEGNEPMATALKHSTHFSTWVLYNCFRAMLIFLMS 557
            |..::|.|.|:|.:|.::|:.::.:..::     ||..   :|.....|||||:..|.|:.:|:|
Mouse   565 LGHILEEFATLQDEAEKVDAALHTMLLKQ-----EPQR---QHLACLGTWVLYHNLRIMIQYLLS 621

  Fly   558 GFELELYAVHEFLYIYWYPYEFLIGFLVSALTRTENILLAQEEYAEHQSKTQSGGSGAAKNRKAA 622
            |||||||::||:.|||||..|||..:|:|.|:|.:...:|:|...|.|.          |.|.:.
Mouse   622 GFELELYSMHEYYYIYWYLSEFLYAWLMSTLSRADGSQMAEERIMEEQQ----------KGRSSK 676

  Fly   623 KPKKNKKTQRPYRAEIVFYHALLSLCGGMYKAMGALTKDGRVRLPLSKFDNEEIRYNRRFLPFAT 687
            |.||.||. ||...||....|..::|.||:|.|.|...||:||.|..:.|:|::||..||.||.:
Mouse   677 KTKKKKKV-RPLSREITMSQAYQNMCAGMFKTMVAFDMDGKVRKPKFELDSEQVRYEHRFAPFNS 740

  Fly   688 LTSPPPVSYAEFKNVREHMMRHS----VEDLYTYAAKHFDQARNVLESIQNPDQEMLDLLQIART 748
            :.:||||.|.:||.:.: :.::|    ..:||..|:|||.||:.:||:|.|||:|:..:|::|:.
Mouse   741 VMTPPPVHYLQFKEMSD-LNKYSPPPQSPELYVAASKHFQQAKMILENIPNPDREVSRILKVAKP 804

  Fly   749 NFVVMNVLARGHQKEVKRQPEFDFSKHSYFPIIKL 783
            |||||.:||.||:||.|..||||||.|.|||::||
Mouse   805 NFVVMKLLAGGHKKESKVPPEFDFSVHKYFPVVKL 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Naa35	NP_611891.1	Mak10	96..230	CDD:282030	68/135 (50%)
Naa35	XP_030103327.1	Mak10	189..324	CDD:367822	68/136 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849860
Domainoid	1	1.000	359	1.000	Domainoid score	I958
eggNOG	1	0.900	-	-		E1_KOG2343
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5781
Inparanoid	1	1.050	506	1.000	Inparanoid score	I1326
Isobase	1	0.950	-	0	Normalized mean entropy	S4516
OMA	1	1.010	-	-		QHG55136
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004758
OrthoInspector	1	1.000	-	-		oto94628
orthoMCL	1	0.900	-	-		OOG6_103368
Panther	1	1.100	-	-	LDO	PTHR21373
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6180
SonicParanoid	1	1.000	-	-		X4443
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740