DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43775 and CRISPLD2

DIOPT Version :9

Sequence 1:	NP_726425.3	Gene:	CG43775 / 37863	FlyBaseID:	FBgn0264297	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	NP_113664.1	Gene:	CRISPLD2 / 83716	HGNCID:	25248	Length:	497	Species:	Homo sapiens

Alignment Length:	199	Identity:	41/199 - (20%)
Similarity:	65/199 - (32%)	Gaps:	67/199 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 PSAKRMRALQWDSELAYMARTHAATVSFMHSECRSTLRFPLAGEVLALSPPVGHRLSLTELLRMV 158
            |.|..|..:.||.||...|...|:...:.|..             .:|...:|..|.
Human    72 PQASNMEYMTWDDELEKSAAAWASQCIWEHGP-------------TSLLVSIGQNLG-------- 115

  Fly   159 FAHIFDEYKTVQDP----QSFARRFDSKRDYS-------------------VGHFSIIVNDRVSR 200
             || :..|::   |    ||:   :|..:||:                   ..|::.||....::
Human   116 -AH-WGRYRS---PGFHVQSW---YDEVKDYTYPYPSECNPWCPERCSGPMCTHYTQIVWATTNK 172

  Fly   201 VGCGFAVGSNCEKD---GKV--GFCHFLTCHFDYTNVNGSYVYKTGKATTGCNDWKTIASIKYSN 260
            :||..   :.|.|.   |:|  ...:|:..:....|..|...||.|:..:.|..       .|..
Human   173 IGCAV---NTCRKMTVWGEVWENAVYFVCNYSPKGNWIGEAPYKNGRPCSECPP-------SYGG 227

  Fly   261 LCEN 264
            .|.|
Human   228 SCRN 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43775	NP_726425.3	SCP_euk	66..228	CDD:240180	32/161 (20%)
CRISPLD2	NP_113664.1	SCP_euk	56..201	CDD:240180	32/160 (20%)
		LCCL	286..370	CDD:128866
		LCCL	387..479	CDD:128866
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151221
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2340
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1528782at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10334
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X35
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850