DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43775 and CRISPLD1

DIOPT Version :9

Sequence 1:	NP_726425.3	Gene:	CG43775 / 37863	FlyBaseID:	FBgn0264297	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	NP_113649.1	Gene:	CRISPLD1 / 83690	HGNCID:	18206	Length:	500	Species:	Homo sapiens

Alignment Length:	319	Identity:	61/319 - (19%)
Similarity:	108/319 - (33%)	Gaps:	128/319 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSILLLA-GLLLLLLPMVAGYNYCNNRTHVCDLAQRKHFMCRLGE---LKPYGGRAKYYASIPD 61
            :|::|.:| .:..:::|         |.|.:..|.::  :|...||   .|..|.||     |.|
Human    11 VTTVLFMARAIPAMVVP---------NATLLEKLLEK--YMDEDGEWWIAKQRGKRA-----ITD 59

  Fly    62 TLKVRKDTLAVLNTFRDMLAGGELDTAENKTFPSAKRMRALQWDSELAYMARTHAATVSFMHSEC 126
                 .|..::|:....:         .::.:|:|..|..:.||.||...|.:.|.:..:.|...
Human    60 -----NDMQSILDLHNKL---------RSQVYPTASNMEYMTWDVELERSAESWAESCLWEHGPA 110

  Fly   127 RSTLRFPLAGEVLALSPPVGHRLSLTELLRMVFAHIFDEYKTVQDPQSFARR--FDSKRDYS--- 186
                         :|.|.:|..|.         || :..|:    |.:|..:  :|..:|:|
Human   111 -------------SLLPSIGQNLG---------AH-WGRYR----PPTFHVQSWYDEVKDFSYPY 148

  Fly   187 ----------------VGHFSIIVNDRVSRVGCGFAVGSNCEKDGKVGFCH-------------F 222
                            ..|::.:|....:|:||.            :..||             :
Human   149 EHECNPYCPFRCSGPVCTHYTQVVWATSNRIGCA------------INLCHNMNIWGQIWPKAVY 201

  Fly   223 LTCHFD-YTNVNGSYVYKTGKATT--------GCNDWKTIASIKYSNLC--ENTGEIFP 270
            |.|::. ..|..|...||.|:..:        ||.:          |||  |.:...:|
Human   202 LVCNYSPKGNWWGHAPYKHGRPCSACPPSFGGGCRE----------NLCYKEGSDRYYP 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43775	NP_726425.3	SCP_euk	66..228	CDD:240180	33/195 (17%)
CRISPLD1	NP_113649.1	SCP_euk	63..207	CDD:240180	32/191 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	254..281
		LCCL	291..375	CDD:128866
		LCCL	392..483	CDD:128866
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151158
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2340
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1528782at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10334
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X35
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850