DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43775 and CRISP2

DIOPT Version :9

Sequence 1:	NP_726425.3	Gene:	CG43775 / 37863	FlyBaseID:	FBgn0264297	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	XP_005249406.1	Gene:	CRISP2 / 7180	HGNCID:	12024	Length:	278	Species:	Homo sapiens

Alignment Length:	234	Identity:	46/234 - (19%)
Similarity:	76/234 - (32%)	Gaps:	65/234 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LGELKPYGGRAKYYASIPDTLKVRKDTLAVLNTFRDMLAGGELDTAENKTFPSAKRMRALQWDSE 107
            |..|...|....:.|.:...|:|:::.:...|..|..::            |.|..|..::|..|
Human    14 LPSLPAEGKDPAFTALLTTQLQVQREIVNKHNELRKAVS------------PPASNMLKMEWSRE 66

  Fly   108 LAYMARTHAATVSFMHSECRSTLRFPLAGEVLALSPPVGHRLSLTELLRMVFAHIFDEYKTVQDP 172
            :...|:..|...:..||:..........||.|.:|                           .||
Human    67 VTTNAQRWANKCTLQHSDPEDRKTSTRCGENLYMS---------------------------SDP 104

  Fly   173 QSFARRFDSKRD------YS---------VGHFSIIVNDRVSRVGCGFAVGSNCEKDGKVGFCHF 222
            .|::....|..|      |.         |||::.:|.....:||||.|...|.:     ...::
Human   105 TSWSSAIQSWYDEILDFVYGVGPKSPNAVVGHYTQLVWYSTYQVGCGIAYCPNQD-----SLKYY 164

  Fly   223 LTCHFDYTNVNGSYVYKTGKATTGCNDWKTIASIKYSNL 261
            ..|  .|.....:|:.|    ..|.|.||....:::..|
Human   165 YVC--QYCPAMKTYLNK----REGINVWKCFLRLRHFQL 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43775	NP_726425.3	SCP_euk	66..228	CDD:240180	32/176 (18%)
CRISP2	XP_005249406.1	SCP_CRISP	35..172	CDD:240183	34/182 (19%)
CRISP2	XP_005249406.1	Crisp	224..278	CDD:285731
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151284
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2340
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1528782at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X35
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750