DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG3253 and LARGE1

DIOPT Version :10

Sequence 1:NP_611886.1 Gene:CG3253 / 37861 FlyBaseID:FBgn0041706 Length:389 Species:Drosophila melanogaster
Sequence 2:NP_004728.1 Gene:LARGE1 / 9215 HGNCID:6511 Length:756 Species:Homo sapiens


Alignment Length:420 Identity:95/420 - (22%)
Similarity:161/420 - (38%) Gaps:132/420 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 FDNINLSYGRWDNQLL---------------------------------YRIKDFAL-------L 39
            |.|:.|::..:|..||                                 :|.:.|.:       |
Human   397 FRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFL 461

  Fly    40 GEQYVDSSEGSLVCLATQTSVERLNSLPQVAANWQGKMSVALFAAGPEEFVVLQYFVTYMRLCFA 104
            ..:|..:::.:.|.|..|.|::||..|..:..:|:|.:|:||:.:..|    .|.|:.|.:....
Human   462 HYEYEPAADSTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAE----AQQFLRYAQGSEV 522

  Fly   105 NI-RENATFHLLTPRDFDKLPRVAALPLNMRGKFDCQYPDRTLKALLKFRSLKTLQWRQRNTYPQ 168
            .: |.|..:|::                                            :::...||.
Human   523 LMSRHNVGYHIV--------------------------------------------YKEGQFYPV 543

  Fly   169 NHMRNLARKGCQTKYVFLTDIDIVPS-------TNSVPQLNHFFRTANCTKSCAYVIPTFE-IDV 225
            |.:||:|.|...|.|:||:|||.:|.       ..||.||:    .||..|  |.::|.|| :..
Human   544 NLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLD----LANTKK--AMIVPAFETLRY 602

  Fly   226 RATFPRSKNALVRLIRKGLARPFHEKVFIYNQYATNFSKWLSPNTNETEVSVSHVVTNFEFLYEP 290
            |.:||:||..|:.::..|....|...|:......|||:||   .|..|...|     .:|..:||
Human   603 RLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKW---RTATTPYRV-----EWEADFEP 659

  Fly   291 FYIAVDNAPAHDERFLGYGFTRNSQVYEMHIAGYQFYVLSPVFTGHWGLQRKQARPAWREQQNNA 355
            :.:...:.|.:|.||:|:|:.:.:.:.|:.:..|:|.||...:..|.                 .
Human   660 YVVVRRDCPEYDRRFVGFGWNKVAHIMELDVQEYEFIVLPNAYMIHM-----------------P 707

  Fly   356 NRRKFDVFKSEIFVRYKNDPRLLLKAKKNQ 385
            :...||:.|    .|.....|:.||..|.:
Human   708 HAPSFDITK----FRSNKQYRICLKTLKEE 733

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG3253NP_611886.1 Glyco_transf_49 52..371 CDD:464027 80/327 (24%)
LARGE1NP_004728.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 43..69
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 81..109
GT8_LARGE_C 138..417 CDD:133053 6/19 (32%)
Xylosyltransferase activity. /evidence=ECO:0000305|PubMed:22223806 138..413 5/15 (33%)
Glucuronyltransferase activity. /evidence=ECO:0000305|PubMed:22223806 414..756 89/403 (22%)
Glyco_transf_49 473..743 CDD:464027 85/344 (25%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.