DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3253 and large2

DIOPT Version :9

Sequence 1:	NP_001246488.1	Gene:	CG3253 / 37861	FlyBaseID:	FBgn0041706	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_001004538.1	Gene:	large2 / 446214	ZFINID:	ZDB-GENE-050419-253	Length:	750	Species:	Danio rerio

Alignment Length:	376	Identity:	90/376 - (23%)
Similarity:	161/376 - (42%)	Gaps:	82/376 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RWDNQLLYRIKDFALLGEQYVDSSEGSLVCLATQTSVERLNSLPQVAANWQGKMSVALFAAGPEE 88
            |.:..:|:|:..: .|..:|..:.:|:.:.|..|.|::||..|..:..:|:|.:|:||:.:..|
Zfish   441 RRERIMLHRVHLY-FLQYEYSPTDDGTDITLVAQLSMDRLQMLEAICKHWEGPISLALYMSDAE- 503

  Fly    89 FVVLQYFVTYMRLC-FANIRENATFHLLTPRDFDKLPRVAALPLNMRGKFDCQYPDRTLKALLKF 152
               .|.|:.|.:.. ....|:|..:|::
Zfish   504 ---AQQFLRYAQASEVLKNRKNVGYHIV------------------------------------- 528

  Fly   153 RSLKTLQWRQRNTYPQNHMRNLARKGCQTKYVFLTDIDIVPS-------TNSVPQLNHFFRTANC 210
                   :::...||.|.:||:|.:...|.||||||:|.:|.       ..|:.||:    .||.
Zfish   529 -------YKEGQFYPVNLVRNVALRNVNTPYVFLTDVDFLPMYGLYDYLRKSIVQLD----MANT 582

  Fly   211 TKSCAYVIPTFE-IDVRATFPRSKNALVRLIRKGLARPFHEKVFIYNQYATNFSKWLSPNTNETE 274
            .|  |.|:|.|| :..|.:||:||..|:.::..|....|...|:......||::||   .|..|.
Zfish   583 KK--ALVVPAFETLRYRLSFPKSKAELLSMLDMGTLYTFRYHVWTKGHAPTNYAKW---RTATTP 642

  Fly   275 VSVSHVVTNFEFLYEPFYIAVDNAPAHDERFLGYGFTRNSQVYEMHIAGYQFYVLSPVFTGH--- 336
            ..|     .:|..:||:.:...:.|.:|:||:|:|:.:.|.:.|:....|...||...|..|
Zfish   643 YKV-----EWEADFEPYVVVRRDCPEYDQRFVGFGWNKVSHIMELDAQEYDLIVLPNAFMIHMPH 702

  Fly   337 ---WGLQRKQARPAWREQQNNANRRKFDVFKSEIFVRYKNDPRLLLKAKKN 384
               :.:.:.::.|::|.......    |.|..::..:|.:.....|.|::|
Zfish   703 APSFDISKFRSSPSYRYCLTTLK----DEFHQDLSRKYGSAALKYLTAQRN 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3253	NP_001246488.1	Glyco_transf_49	52..371	CDD:290607	80/333 (24%)
large2	NP_001004538.1	GT8_LARGE_C	132..411	CDD:133053
		Xylosyltransferase activity. /evidence=ECO:0000250\|UniProtKB:O95461	132..407
		Glucuronyltransferase activity. /evidence=ECO:0000250\|UniProtKB:O95461	408..750		90/376 (24%)
		Glyco_transf_49	467..736	CDD:316419	80/334 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3765
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5095
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840