DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3253 and large1

DIOPT Version :9

Sequence 1:	NP_001246488.1	Gene:	CG3253 / 37861	FlyBaseID:	FBgn0041706	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_001004537.1	Gene:	large1 / 446213	ZFINID:	ZDB-GENE-061204-1	Length:	757	Species:	Danio rerio

Alignment Length:	414	Identity:	94/414 - (22%)
Similarity:	155/414 - (37%)	Gaps:	126/414 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FDNINLSYGRWDNQLL---------------------------------YRIKDFAL-------L 39
            |.|:.|::..:|..||                                 :|.:.|.:       |
Zfish   398 FRNLYLTFLEYDGNLLRRELFGCPSETDHNSENLQKTLSELDEDDPCYEFRRERFTVHRTHVYFL 462

  Fly    40 GEQYVDSSEGSLVCLATQTSVERLNSLPQVAANWQGKMSVALFAAGPEEFVVLQYFVTYMRLCFA 104
            ..:|..:.:.:.|.|..|.|::||..|..:..:|:|.:|:||:.:..|    .|.|:.|.:....
Zfish   463 HYEYEPTVDNTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAE----AQQFLRYAQGSEV 523

  Fly   105 NI-RENATFHLLTPRDFDKLPRVAALPLNMRGKFDCQYPDRTLKALLKFRSLKTLQWRQRNTYPQ 168
            .: |.|..:|::                                            :::...||.
Zfish   524 LMSRSNVGYHIV--------------------------------------------YKEGQFYPV 544

  Fly   169 NHMRNLARKGCQTKYVFLTDIDIVPS-------TNSVPQLNHFFRTANCTKSCAYVIPTFE-IDV 225
            |.:||:|.....|.|:||:|||.:|.       ..||.||:    ..|..|  |.|:|.|| :..
Zfish   545 NLLRNVAMGQVNTPYMFLSDIDFLPMYGLYEYLRKSVVQLD----MGNTKK--ALVVPAFETLRY 603

  Fly   226 RATFPRSKNALVRLIRKGLARPFHEKVFIYNQYATNFSKWLSPNTNETEVSVSHVVTNFEFLYEP 290
            |.:||:||..|:..:..|....|...|:......|:|:||   .|..|...|     .:|..:||
Zfish   604 RLSFPKSKAELLSQLDMGTLFTFRYHVWTKGHAPTDFAKW---RTATTPYRV-----QWEADFEP 660

  Fly   291 FYIAVDNAPAHDERFLGYGFTRNSQVYEMHIAGYQFYVLSPVFTGHWG----------LQRKQAR 345
            :.:....:|.:|.||:|:|:.:.:.:.|:....|:|.||...:..|..          ...||.|
Zfish   661 YVMVRRESPEYDRRFVGFGWNKVAHIMELDAQEYEFVVLPNAYMIHMPHAPSFDITKFRSNKQYR 725

  Fly   346 PAWRE-----QQNNANRRKFDVFK 364
            ...:.     |||.:.|..|...|
Zfish   726 ACLKTLKEEFQQNMSRRYGFAALK 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3253	NP_001246488.1	Glyco_transf_49	52..371	CDD:290607	84/337 (25%)
large1	NP_001004537.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..127
		RfaJ	137..>387	CDD:224359
		GT8_LARGE_C	139..418	CDD:133053	6/19 (32%)
		Xylosyltransferase activity. /evidence=ECO:0000250\|UniProtKB:O95461	139..414		5/15 (33%)
		Glucuronyltransferase activity. /evidence=ECO:0000250\|UniProtKB:O95461	415..757		88/397 (22%)
		Glyco_transf_49	474..743	CDD:290607	81/330 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D729091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920