Protein Alignment CG4049 and CHD9

DIOPT Version :10

• Sequence 1: NP_611885.3
• Gene: CG4049 / 37860
• FlyBaseID: FBgn0034976
• Length: 1669
• Species: Drosophila melanogaster
• Sequence 2: XP_005256225.1
• Gene: CHD9 / 80205
• HGNCID: 25701
• Length: 2898
• Species: Homo sapiens
• Alignment Length: 1723
• Identity: 333/1723 - (19%)
• Similarity: 536/1723 - (31%)
• Gaps: 660/1723 - (38%)

  Fly     5 EANMEESNPNYDVNQRLQKPEGWPHVNEFHPSMMYPDDPRRYFHNASTDPQHQPQQHPQQQPEQ- 68
            |:.....|||..:|.           |.|  .:::...|:..:.|:...|.|.....|.....|
Human   320 ESTQHILNPNTSLNS-----------NNF--QILHSSHPQGNYSNSKLSPVHMNFPDPVDSGTQM 371

  Fly    69 -HPEQHPQ------------HPLHSQQQP------------------------------------ 84
             |...|.:            |.:.||.:|
Human   372 GHFNDHVETNGFSSLEENLLHQVESQTEPFTGLDPEDLLQEGLLPHFDESTFGQDNSSHILDHDL 436

  Fly    85 ----QQHPQQQPQQHPQQQTQQPPQ-----------LQPQQHPQAQIQPPIPVPISTPMEGTMEV 134
                ..|...:|....|.|.|...:           |..:.|...|.||    |.|...:|:
Human   437 DRQFTSHLVTRPSDMAQTQLQSQARSWHSSFSNHQHLHDRNHLCLQRQP----PSSKKSDGS--- 494

  Fly   135 PVKMPEYCPETSQPVEPDRVINPLAEVAKNTVPYGHKRKNSAGEDQAANKKLSMAAAEEKKNSHL 199
                ..|....:..|   ||::...:         .|:..|..:.:.||:.:|.|.|:.|:..
Human   495 ----GTYTKLQNTQV---RVMSEKKQ---------RKKVESESKQEKANRIISEAIAKAKERG-- 541

  Fly   200 RKNIRDVMNENNLDTTTLAAQREESER-----------------------------LARVAGQQK 235
            .:||..||:..|..|.::..:.|:..|                             :..:..:||
Human   542 ERNIPRVMSPENFPTASVEGKEEKKGRRMKSKPKDKDSKKTKTCSKLKEKTKIGKLIITLGKKQK 606

  Fly   236 SMRE--------------------IQKQVVHKQIFRILQLDESEGIESCAVAN----------PV 270
            ...|                    .||:..::||.|....::.||.:|.....          |:
Human   607 RKNESSDEISDAEQMPQHTLKDQDSQKRRSNRQIKRKKYAEDIEGKQSEEEVKGSMKIKKNSAPL 671

  Fly   271 EHHPP----VDFPEEEIAS--DTFDDSNS--SSLSGGSIED-----VLHKGASVQPSEVVTIDDS 322
            ....|    |:.|.||.|:  |....|.:  ..:|.|.:.|     |.:|..|....|..|.:..
Human   672 PGEQPLQLFVENPSEEDAAIVDKILSSRTVKKEISPGVMIDTEEFFVKYKNYSYLHCEWATEEQL 736

  Fly   323 SDDDCI----------------LLSEEEEEEDDEDLNESDDATN-SGMHVKD-----IY------ 359
            ..|..|                ..::.|||..:.|..|.|.... |....||     ||
Human   737 LKDKRIQQKIKRFKLRQAQRAHFFADMEEEPFNPDYVEVDRVLEVSFCEDKDTGEPVIYYLVKWC 801

  Fly   360 NVPDENG----QVVVNMAHPEGEETLYLA-PQIAKVIKP----------------------HQIG 397
            ::|.|:.    :..|::|..|..|.|..: |...::.:|                      :|:.
Human   802 SLPYEDSTWELKEDVDLAKIEEFEQLQASRPDTRRLDRPPSNIWKKIDQSRDYKNGNQLREYQLE 866

  Fly   398 GVRFLYDNIIESTRRYNKSSGFGCILAHSMGLGKTLQVVSFCDIFLRHTSAKTVLCVMPINTLQN 462
            |:.:|..|      .||:.:   ||||..||||||:|.::|....|........|.:.|::|:.|
Human   867 GLNWLLFN------WYNRRN---CILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIAN 922

  Fly   463 WLSEFNMWIPRYSTDSNVRPRNFDIFVLNDQQKTLTARAKVILNWVHDGGV----LLIGYELFRL 523
            |..||..|     ||.||                          .|:.|.:    ::..||::
Human   923 WEREFRTW-----TDINV--------------------------VVYHGSLISRQMIQQYEMY-- 954

  Fly   524 LALKLVKTRKRKGSVIRPDGMDSSSDLMNLVYEALVKPGPDL-------VICDEGHRIKNSHAGI 581
                   .|..:|.:||  |......::. .:|.::....:|       ||.||.||:||.:..:
Human   955 -------FRDSQGRIIR--GAYRFQAIIT-TFEMILGGCGELNAIEWRCVIIDEAHRLKNKNCKL 1009

  Fly   582 SLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCNMFERPIQNGQCVDSTPDD 646
            ...||.:....:::|||.||||.:.|.:.::.|:.|....:.:.|...|              .|
Human  1010 LEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEF--------------GD 1060

  Fly   647 IKLMRYRAHVLHSLLLGFVQRRSHTVLQLTLPQKYEYVILVKMTAFQRKLYD-------TFMTDV 704
            :| ...:...|.::|...:.||....::..|..|.|.:|.|::|..|:|.|.       :|::..
Human  1061 LK-TEEQVQKLQAILKPMMLRRLKEDVEKKLAPKEETIIEVELTNIQKKYYRAILEKNFSFLSKG 1124

  Fly   705 VRTKAFPNPLKAFAVCCKIWNHPDVLYNFLKKCETDLDLEIDEEVTKGAATPIVEPSADSSLSLA 769
            ......||.:.......|..|||.::                    |||
Human  1125 AGQTNVPNLVNTMMELRKCCNHPYLI--------------------KGA---------------- 1153

  Fly   770 SPLEKKINGSGDPINSIETFSKAENQTLFNIPASSDLNAKYLNKSPSFYDEKPEPLNYGSFGSEG 834
               |:||.|              |.:..:| ||:||.:.:.:
Human  1154 ---EEKILG--------------EFRDTYN-PAASDFHLQAM----------------------- 1177

  Fly   835 KNNYWMDSSILPKPGCVEVIKQTDTNMSSNFESITGSSEIVDLDTNEIKTVETTIQAPCSNNQLD 899
                                             |..:.::|.:|
Human  1178 ---------------------------------IQSAGKLVLID--------------------- 1188

  Fly   900 NGCNAGKPSEWNAAGSKNSSGVAAAEPFKKLLKSKQRNEEFSCSWAVDLMKNYVSGLISNSPKME 964
                                         |||                             |||:
Human  1189 -----------------------------KLL-----------------------------PKMK 1195

  Fly   965 IFFCILKESLNLGDRILLFSQSLLTLNLLEVYLKSSYVPGSNQLWTKNSSYFRLDGSTSSQERER 1029
            ..          |.::|:|||.:..|::||.||..           |...|.|:||......|:.
Human  1196 AG----------GHKVLIFSQMVRCLDILEDYLIH-----------KRYLYERIDGRVRGNLRQA 1239

  Fly  1030 LVNEFN-ANSNVKLFLISTRAGSLGINLTGANRVIIFDASWNPCHDTQAVYRIYRYGQTKPCFVY 1093
            .::.|: .:|:..:||:.||||.||||||.|:..||||:.|||.:|.||..|.:|.||.|...||
Human  1240 AIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQNKAVKVY 1304

  Fly  1094 RIVMDRCLEKKIYDRQIKKQGMSDRIVDECNPE-------AHLSMKDITNL-------------- 1137
            |:|.....|::::||...|.|:...::...:..       ..||.|:|.:|
Human  1305 RLVTRNSYEREMFDRASLKLGLDKAVLQSMSGRESNVGGIQQLSKKEIEDLLRRGAYGAIMEEED 1369

  Fly  1138 -----CQDYDSDEDTVEEVNKSTGDLSKPGSPSEEGSKPGSANMSPNASNKSNNGPTKPLDDQNT 1197
                 |:: |.|:..:......|.:....||...:.|...|.|.:..:           |||.|.
Human  1370 EGSKFCEE-DIDQILLRRTKTITIESEGRGSTFAKASFVASGNRTDIS-----------LDDPNF 1422

  Fly  1198 PKSPNGASHSPIKTEKNDGQEHAVHVDGIINTILDMHRHCVTKEPFMHESLLVDQKDRKLSQAE- 1261
            .:  ..|..:.|..|...|:.         :.::|..|......||   |...|:. .:||:||
Human  1423 WQ--KWAKKAEIDIEAISGRN---------SLVIDTPRIRKQTRPF---SATKDEL-AELSEAES 1472

  Fly  1262 --------KRQAHRS--------YELEKKAAV----NQRFTYAPAKMNYKIVNNDGTVITKPMNQ 1306
                    :|...||        :.:||...|    ..|...:..:...::..:|..:|.:.:..
Human  1473 EGDEKPKLRRPCDRSNGYGRTECFRVEKNLLVYGWGRWREILSHGRFKRQLNEHDVEIICRALLA 1537

  Fly  1307 QIKTNTSSSTGGRSTRWIPADVWQRQGMTAQEMTLPLDVVIPTNSADKANIILKAGQRVMVLKSA 1371
            ....:.      |....|...:|              |::.||.......:....|....|.:..
Human  1538 YCLVHY------RGDEKIKGFIW--------------DLITPTEDGQTRELQNHLGLSAPVPRGR 1582

  Fly  1372 KG--IYMQLDSGKIIAIRTTAKTEPEKTNKDD--------------------------------- 1401
            ||  :..|..|..|.......|..||:..:|:
Human  1583 KGKKVKTQTSSFDIQKAEWLRKYNPEQLLQDEGYKKHIKHHCNKVLLRVRMLYYLKQEVIGNECQ 1647

  Fly  1402 -VIDITDDGDTDTTKPQSPEEDVK----DLTAD 1429
             |.|..|..|.|...|:....:|.    |..||
Human  1648 KVFDGVDASDIDVWVPEPDHSEVPAEWWDFDAD 1680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4049	NP_611885.3	DEXHc_ARIP4	391..653	CDD:350827	67/294 (23%)
		HepA	<392..1121	CDD:440319	164/769 (21%)
CHD9	XP_005256225.1	GAT1	161..558	CDD:227928	50/275 (18%)
		ROM1	176..>362	CDD:227709	11/54 (20%)
		CD1_tandem_CHD5-9_like	686..750	CDD:349315	15/63 (24%)
		CD2_tandem_CHD5-9_like	770..828	CDD:349310	14/57 (25%)
		PLN03142	811..>1480	CDD:215601	202/972 (21%)
		BRK	2483..2532	CDD:197800
		BRK	2557..2601	CDD:197800