Protein Alignment CG4049 and SMARCA2

DIOPT Version :10

• Sequence 1: NP_611885.3
• Gene: CG4049 / 37860
• FlyBaseID: FBgn0034976
• Length: 1669
• Species: Drosophila melanogaster
• Sequence 2: NP_003061.3
• Gene: SMARCA2 / 6595
• HGNCID: 11098
• Length: 1590
• Species: Homo sapiens
• Alignment Length: 1871
• Identity: 364/1871 - (19%)
• Similarity: 591/1871 - (31%)
• Gaps: 750/1871 - (40%)

  Fly     1 MDNPEANMEESNPNY--------DVNQRLQKPEGW-----PHVNEFHPSMMYPDDPRRYFHNAST 52
            |..|::.|::.:..|        ...:.:..|...     |.:....|..:.|.||:     |.:
Human   106 MGPPQSPMDQHSQGYMSPHPSPLGAPEHVSSPMSGGGPTPPQMPPSQPGALIPGDPQ-----AMS 165

  Fly    53 DPQHQP------QQH--------------------------------PQQQPEQHPEQHPQHPLH 79
            .|...|      |.|                                |..|.:|..:|..|....
Human   166 QPNRGPSPFSPVQLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQQQQQ 230

  Fly    80 SQQQPQQHPQQQPQQHPQQQTQQP------------PQL----------------QPQQHPQAQI 116
            .|||.||.|||||.|...||.|||            |:|                :|...|.|..
Human   231 QQQQQQQQPQQQPPQPQTQQQQQPALVNYNRPSGPGPELSGPSTPQKLPVPAPGGRPSPAPPAAA 295

  Fly   117 QPP---IPVP-ISTPMEG----TMEVPVKM----PEYCPETSQPVE------------------- 150
            |||   :|.| :..|..|    .:::..|.    |...|:...|||
Human   296 QPPAAAVPGPSVPQPAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREYRLQARIAHRIQE 360

  Fly   151 ---------PD------------RVIN----------------PLAEVAKNTVPYGHKRKNSAGE 178
                     ||            |::|                ...|.|.|:..|...::.:..|
Human   361 LENLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVACMRRDTTLETALNSKAYKRSKRQTLRE 425

  Fly   179 DQAANK-------------------------------------------KLSMAAA--------E 192
            .:...|                                           |||.|.|        |
Human   426 ARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTERE 490

  Fly   193 EKKNSHL--RKNIRDVMNENNLDTTTLAAQREE----------------------SERLARVAGQ 233
            :||.:..  ::.:|.:|.|:......|..|:::                      ..:.|:.|.:
Human   491 QKKETERIEKERMRRLMAEDEEGYRKLIDQKKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKE 555

  Fly   234 QKSMREIQKQVVHKQIFRILQLDESEGIESC--AVANPVEHHP-----PVDFPEEEIASDTF-DD 290
            :|..|..:|:..          :.:||.||.  ....|::...     ||.....|.....| .:
Human   556 KKKRRRRKKKAE----------ENAEGGESALGPDGEPIDESSQMSDLPVKVTHTETGKVLFGPE 610

  Fly   291 SNSSSLSGGSIEDVLHKGASVQPSEVVTIDDSSDDDCILLSEEEEEEDDEDLNESD-----DATN 350
            :..:|.....:|  ::.|..|.|.   :..:.||.|    .|||:||::....|::     |..:
Human   611 APKASQLDAWLE--MNPGYEVAPR---SDSEESDSD----YEEEDEEEESSRQETEEKILLDPNS 666

  Fly   351 SGMHVKDI--------YNVPDE--------NGQVVVNMAHPEGEETLYLAPQIAKVI----KPHQ 395
            ..:..||.        .:|.||        ..|....:||...|.   :..|.|.:|    |.:|
Human   667 EEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISER---VEKQSALLINGTLKHYQ 728

  Fly   396 IGGVRF---LYDNIIESTRRYNKSSGFGCILAHSMGLGKTLQVVSFCDIFLRHTSAK-TVLCVMP 456
            :.|:.:   ||:|.:..            |||..||||||:|.::.....:.|.... ..|.::|
Human   729 LQGLEWMVSLYNNNLNG------------ILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVP 781

  Fly   457 INTLQNWLSEFNMWIPRYSTDSNVRPRNFDIFVLNDQQKTLTARAKVILNWVHDG--GVLLIGYE 519
            ::||.||..||:.|.|.               |:....|...|..:.::..:..|  .|||..||
Human   782 LSTLSNWTYEFDKWAPS---------------VVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYE 831

  Fly   520 LFRLLALKLVKTRKRKGSVIRPDGMDSSSDLMNLVYEALVKPGPDLVICDEGHRIKNSHAGISLA 584
            .       ::|.:                       ..|.|.....:|.|||||:||.|..::..
Human   832 Y-------IIKDK-----------------------HILAKIRWKYMIVDEGHRMKNHHCKLTQV 866

  Fly   585 LK-EIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCNMFERPI-QNGQCVDSTPDDI 647
            |. .....|||:|||.||||.|.|.|.:::|:.|....:.:.|...|..|. ..|:.||...::.
Human   867 LNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEET 931

  Fly   648 KLMRYRAHVLHSLLLGFVQRRSHTVLQLTLPQKYEYVILVKMTAFQRKLYDTFMTDVVRTKAFPN 712
            .|:..|   ||.:|..|:.||....::..||:|.||||...|:|.|:
Human   932 ILIIRR---LHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQK------------------ 975

  Fly   713 PLKAFAVCCKIWNHPDVLYNFLKKCETDLDLEIDEEVTKGAATPIVEPSADSSLSLASPLEKKIN 777
                            :||..::              .||             :.|....||...
Human   976 ----------------ILYRHMQ--------------AKG-------------ILLTDGSEKDKK 997

  Fly   778 GSGDPINSIETFSKAENQTLFNIPASSDLNAKYLNKSPSFYDEKPEPLNYGSFGSEGKNNYWMDS 842
            |.|.
Human   998 GKGG------------------------------------------------------------- 1001

  Fly   843 SILPKPGCVEVIKQTDTNMSSNFESITGSSEIVDLDTNEIKTVETTIQAPCSNNQLDNGCNAGKP 907
                                                   .||:..||.      ||...||
Human  1002 ---------------------------------------AKTLMNTIM------QLRKICN---- 1017

  Fly   908 SEWNAAGSKNSSGVAAAEPFKKLLKSKQRNEEFSCSWAVDLMKNYVSGLISN------SPKMEIF 966
                             .|:     ..|..||   |:|..|  .|.:|:|:.      |.|.|:.
Human  1018 -----------------HPY-----MFQHIEE---SFAEHL--GYSNGVINGAELYRASGKFELL 1055

  Fly   967 FCILKESLNLGDRILLFSQSLLTLNLLEVYLKSSYVPGSNQLWTKNSSYFRLDGSTSSQERERLV 1031
            ..||.:......|:|||.|....:.::|.|..           .:|..|.||||:|.|::|..|:
Human  1056 DRILPKLRATNHRVLLFCQMTSLMTIMEDYFA-----------FRNFLYLRLDGTTKSEDRAALL 1109

  Fly  1032 NEFN-ANSNVKLFLISTRAGSLGINLTGANRVIIFDASWNPCHDTQAVYRIYRYGQTKPCFVYRI 1095
            .:|| ..|...:||:|||||.||:||..|:.|:|||:.|||..|.||..|.:|.||.....|.|:
Human  1110 KKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRL 1174

  Fly  1096 VMDRCLEKKI---------YDRQIKKQGMSDRIVDECNPEAHLSM---KDITNLCQDYDSDEDTV 1148
            .....:|:||         .|:::.:.||.|:........|.|..   .:..|..:|...|::|:
Human  1175 CTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEENEEEDEVPDDETL 1239

  Fly  1149 EE------------------------------------------VNKSTGDLSKPGSPSEE---- 1167
            .:                                          :.|...::.:.....||
Human  1240 NQMIARREEEFDLFMRMDMDRRREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKIF 1304

  Fly  1168 --GSKP-GSANMSPNASNKS-----NNGPTKPLDDQ----------NTPKSPNGASHSPIKTEKN 1214
              ||:. ...:.|...:.|.     .:|..:.::::          |..|.|  |.....|.:|.
Human  1305 GRGSRQRRDVDYSDALTEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDP--AKEDVEKAKKR 1367

  Fly  1215 DGQEHA-----------VHVDGIINTILDMHRHCVTKEPFMHESLLVDQKDRKLSQAEKRQAHRS 1268
            .|:..|           ..::.||:|:                   ::.|||  ...||..::..
Human  1368 RGRPPAEKLSPNPPKLTKQMNAIIDTV-------------------INYKDR--CNVEKVPSNSQ 1411

  Fly  1269 YELEKKAA---VNQRFTYAPAKMN----YKIVNNDGTVITKPMNQQIKTNTSSSTGGRSTRWIPA 1326
            .|:|..::   :::.|...|::..    |:::..  .|..|.:.::|:.:...|.|
Human  1412 LEIEGNSSGRQLSEVFIQLPSRKELPEYYELIRK--PVDFKKIKERIRNHKYRSLG--------- 1465

  Fly  1327 DVWQRQGMTAQEMTLPLDVVIPTNSADKANIILKAGQRVMVLKSAKGIYMQLDSGKIIAIRTTAK 1391
                         .|..||::..::|...|:              :|..:..||   |.:::..|
Human  1466 -------------DLEKDVMLLCHNAQTFNL--------------EGSQIYEDS---IVLQSVFK 1500

  Fly  1392 TEPEKTNKDDVIDITDDGDTDTTKPQSPEEDVKDLTADDEPRVVKNKESNPATTSRPEMPAKDRK 1456
            :..:|..|::..:       |.:..:..|||.::  ::.|.:.||.|         .::..||.|
Human  1501 SARQKIAKEEESE-------DESNEEEEEEDEEE--SESEAKSVKVK---------IKLNKKDDK 1547

  Fly  1457 STENVQHFKSQTQPNTTLATTTNQHQLPSDLTYSQPQQSHQQPQQQASQQQ 1507
            ..:.   .|.:.:||...|     ..:.||....:.|...:|.:...:..:
Human  1548 GRDK---GKGKKRPNRGKA-----KPVVSDFDSDEEQDEREQSEGSGTDDE 1590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4049	NP_611885.3	DEXHc_ARIP4	391..653	CDD:350827	72/273 (26%)
		HepA	<392..1121	CDD:440319	175/752 (23%)
SMARCA2	NP_003061.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71
		Atrophin-1	<46..>450	CDD:460830	64/348 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..176		13/74 (18%)
		QLQ	173..207	CDD:462622	2/33 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..334		35/121 (29%)
		HSA	436..508	CDD:214727	9/71 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	551..592		9/50 (18%)
		BRK	589..632	CDD:462196	8/44 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	627..672		12/51 (24%)
		DEXHc_SMARCA2	701..951	CDD:350821	84/312 (27%)
		PLN03142	720..>1202	CDD:215601	173/750 (23%)
		DEGH box	851..854		2/2 (100%)
		SnAC	1259..1326	CDD:464219	7/66 (11%)
		Bromodomain	1333..>1419	CDD:445827	18/108 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1344..1383		8/40 (20%)
		Bromo_SNF2L2	1382..1506	CDD:99947	28/185 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1506..1590		20/109 (18%)