Protein Alignment CG4049 and ERCC6L

DIOPT Version :10

• Sequence 1: NP_611885.3
• Gene: CG4049 / 37860
• FlyBaseID: FBgn0034976
• Length: 1669
• Species: Drosophila melanogaster
• Sequence 2: NP_060139.2
• Gene: ERCC6L / 54821
• HGNCID: 20794
• Length: 1250
• Species: Homo sapiens
• Alignment Length: 1359
• Identity: 274/1359 - (20%)
• Similarity: 461/1359 - (33%)
• Gaps: 462/1359 - (33%)

  Fly   278 FPEEEIASD-------TFDDSNSSSLSGGSIED---VLHKGASVQPSEVV-----TIDDSSDDDC 327
            |||.|..|.       .:......:...|.:|:   :.:....:.|:|.|     .|.::
Human     7 FPEAEALSPEQAAHYLRYVKEAKEATKNGDLEEAFKLFNLAKDIFPNEKVLSRIQKIQEA----- 66

  Fly   328 ILLSEEEEEEDDEDLNESDDATNSGMHVKDIYNVPDENGQVVVNMAHPEGEETLYLAPQIAKVIK 392
              |.|..|:.||    |..|..|||                            |.|..::...:.
Human    67 --LEELAEQGDD----EFTDVCNSG----------------------------LLLYRELHNQLF 97

  Fly   393 PHQIGGVRFLYDNIIESTRRYNKSSGFGCILAHSMGLGKTLQVVSFCDIFLRHTSAKTVLCVMPI 457
            .||..|:.|||     |..|..:..|   |||..||||||:|:::|.......:....||.:||.
Human    98 EHQKEGIAFLY-----SLYRDGRKGG---ILADDMGLGKTVQIIAFLSGMFDASLVNHVLLIMPT 154

  Fly   458 NTLQNWLSEFNMWIP--RYST----DSNVRPRNFDIFVLNDQQKTLTARAKVILNWVHDGGVLLI 516
            |.:..|:.||..|.|  |..|    ..:.|.||     ||..|:.              .||::.
Human   155 NLINTWVKEFIKWTPGMRVKTFHGPSKDERTRN-----LNRIQQR--------------NGVIIT 200

  Fly   517 GYELFRLLALKLVKTRKRKGSVIRPDGMDSSSDLMNLVYEALVKPGPDLVICDEGHRIKNSHAGI 581
            .|::       |:...::.          ||......|:        |.||.||.|:||.|....
Human   201 TYQM-------LINNWQQL----------SSFRGQEFVW--------DYVILDEAHKIKTSSTKS 240

  Fly   582 SLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFV-RPNYLGTRTEFCNMFERPIQNGQCVDSTPD 645
            ::..:.|....|::|||.|:||||.|.|.:.||. :.:.|||...|...:|.||...:..|:||.
Human   241 AICARAIPASNRLLLTGTPIQNNLQELWSLFDFACQGSLLGTLKTFKMEYENPITRAREKDATPG 305

  Fly   646 DIKLMRYRAHVLHSLLLGFVQRRSHTVLQL------------------------TLPQKYEYVIL 686
            :..|....:..|.:::..:..||:...:|.                        :|.:|.:.:|.
Human   306 EKALGFKISENLMAIIKPYFLRRTKEDVQKKKSSNPEARLNEKNPDVDAICEMPSLSRKNDLIIW 370

  Fly   687 VKMTAFQRKLYDTFMT-DVVRTKAFP--NPLKAFAVCCKIWNHPDVLYNFLKKCETDLDLEIDEE 748
            :::...|.::|..|:: |.::.....  :||....|..|:.:||.:|
Human   371 IRLVPLQEEIYRKFVSLDHIKELLMETRSPLAELGVLKKLCDHPRLL------------------ 417

  Fly   749 VTKGAATPIVEPSADSSLSLASPLEKKINGSGDPINSIETFSKAENQTLFNIPASSDLNAKYLNK 813
                        ||.:...|                ::.|||..:
Human   418 ------------SARACCLL----------------NLGTFSAQD-------------------- 434

  Fly   814 SPSFYDEKPEPLNYGSFGSEGKNNYWMDSSILPKPGCVEVIKQTDTNMSSNFESITGSSEIVDLD 878
                             |:||:::          |....:.:.||                   |
Human   435 -----------------GNEGEDS----------PDVDHIDQVTD-------------------D 453

  Fly   879 TNEIKTVETTIQAPCSNNQLDNGCNAGKPSEWNAAGSKNSSGVAAAEPFKKLLKSKQRNEEFSCS 943
            |
Human   454 T---------------------------------------------------------------- 454

  Fly   944 WAVDLMKNYVSGLISNSPKMEIFFCILKESLNLGDRILLFSQSLLTLNLLEVYLKSSYVPGSNQL 1008
                        |:..|.||.....:||...:.|.:.|:||||...||::|..||:
Human   455 ------------LMEESGKMIFLMDLLKRLRDEGHQTLVFSQSRQILNIIERLLKN--------- 498

  Fly  1009 WTKNSSYFRLDGS-TSSQERERLVNEFNANSNVKLFLISTRAGSLGINLTGANRVIIFDASWNPC 1072
              ::....|:||: |...|||:.:|.|..|.:..:||::|:.|.:|:.||.|.||:|||.||||.
Human   499 --RHFKTLRIDGTVTHLLEREKRINLFQQNKDYSVFLLTTQVGGVGLTLTAATRVVIFDPSWNPA 561

  Fly  1073 HDTQAVYRIYRYGQTKPCFVYRIVMDRCLEKKIYDRQIKKQGMSDRIVDE-CNPEAHLSMKDITN 1136
            .|.|||.|:||.||.:...|||::....:|:|||.||:.|..:..:...| .||..:.|.:::..
Human   562 TDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQVFKDSLIRQTTGEKKNPFRYFSKQELRE 626

  Fly  1137 LCQDYDSDEDTVEEVNKSTGDLSKPGSPSEEGSKPGSANMSPNASNKSNNGPTKPLDDQNTPKSP 1201
            |.        |:|::..|...|..               .|.:|:.:.
Human   627 LF--------TIEDLQNSVTQLQL---------------QSLHAAQRK----------------- 651

  Fly  1202 NGASHSPIKTEKNDGQEHAVHVDGIINTILDMHRHCVTKEPFMHESLLVDQKDRKLSQ-AEKRQA 1265
                 |.||.:     ||..::..:....:..|....|.:..:.|.|.|.::...:.| .:|.|.
Human   652 -----SDIKLD-----EHIAYLQSLGIAGISDHDLMYTCDLSVKEELDVVEESHYIQQRVQKAQF 706

  Fly  1266 HRSYELEKKAAVNQRFTYAPAKMNYKIVNNDGTVITKPMNQQIKTNTSSSTGGRSTRWIPADVWQ 1330
            ...:|.:.|..:          |..:...|:|..:.:|:       ..|||..:..: :.....|
Human   707 LVEFESQNKEFL----------MEQQRTRNEGAWLREPV-------FPSSTKKKCPK-LNKPQPQ 753

  Fly  1331 RQGMTAQEMTLPLDVVIPTNSADKANIIL----KAGQR---------VMVLKSAKGIYMQLDSGK 1382
            ...:.:...|...|:     |:..|::::    |.|::         |..|:..||      :|.
Human   754 PSPLLSTHHTQEEDI-----SSKMASVVIDDLPKEGEKQDLSSIKVNVTTLQDGKG------TGS 807

  Fly  1383 IIAIRTTAK----TEPEKTNKDDVIDITDDGDTDTTKPQSPEEDVKDLTADDEPRVVKNKESNPA 1443
            ..:|.|..|    .|...||....::.:.....:..:.::.:|..|.....::|....|...:.:
Human   808 ADSIATLPKGFGSVEELCTNSSLGMEKSFATKNEAVQKETLQEGPKQEALQEDPLESFNYVLSKS 872

  Fly  1444 TTSRPEMPAKDRKSTENVQHFK-----SQTQPNTTLATTTNQHQLPSDLTYSQPQQSHQQPQQQA 1503
            |.:.........|..|.::|..     |.|..:....:..:..::..||:.|.......|..:..
Human   873 TKADIGPNLDQLKDDEILRHCNPWPIISITNESQNAESNVSIIEIADDLSASHSALQDAQASEAK 937

  Fly  1504 SQQQPAQQPP-----------PPAYKHQNHLPAAGEGYSNANSIQPNVPLPPHPGAPNS 1551
            .:::|:...|           ..|...||....:.|.....||:..:        ||||
Human   938 LEEEPSASSPQYACDFNLFLEDSADNRQNFSSQSLEHVEKENSLCGS--------APNS 988

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4049	NP_611885.3	DEXHc_ARIP4	391..653	CDD:350827	79/268 (29%)
		HepA	<392..1121	CDD:440319	174/763 (23%)
ERCC6L	NP_060139.2	TPR 1	21..54		3/32 (9%)
		HepA	<90..610	CDD:440319	174/770 (23%)
		DEXHc_ERCC6L	96..328	CDD:350759	80/283 (28%)
		DEAH box	228..231		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	735..768		5/40 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	926..946		2/19 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1061..1092
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1110..1199
		TPR 2	1200..1233