Protein Alignment CG4049 and Mi-2

DIOPT Version :10

• Sequence 1: NP_611885.3
• Gene: CG4049 / 37860
• FlyBaseID: FBgn0034976
• Length: 1669
• Species: Drosophila melanogaster
• Sequence 2: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Alignment Length: 1691
• Identity: 311/1691 - (18%)
• Similarity: 548/1691 - (32%)
• Gaps: 617/1691 - (36%)

  Fly   123 PISTPMEGTMEVPVKMPEYCPETSQPVEPDRVINPLAEVAKNTVPY-GHKRKNSAGEDQAANKKL 186
            |:.|..:|...        ||..|.|        ||...|:..:.: ..:|.|..|...:...|.
  Fly   468 PLDTIPDGDWR--------CPRCSCP--------PLTGKAEKIITWRWAQRSNDDGPSTSKGSKN 516

  Fly   187 SMAAAEEKKNSHLRKNIRDVMNENNLDTTTLAAQREESERLARVAGQQKSMREIQKQVVHKQIFR 251
            |        ||.:|:..   :..:|:.                 ....:.:.|:|..|.|..:.|
  Fly   517 S--------NSRVREYF---IKWHNMS-----------------YWHCEWVPEVQLDVHHPLMIR 553

  Fly   252 ILQ--------------LDESEGIESCAVANPVEHHPPVDFPEEEIASDTFDDSNSSSLSGGSIE 302
            ..|              |||::     .....::.|      ::::.....||:.       .:|
  Fly   554 SFQRKYDMEEPPKFEESLDEAD-----TRYKRIQRH------KDKVGMKANDDAE-------VLE 600

  Fly   303 DVLHKGASVQPSEVV--------TIDDSSDDDCILLSE--------EEEEEDDEDLNESDD---- 347
            :..:|. .|:|..::        |..|.|....:...|        |||.:|.:.|.::.|
  Fly   601 ERFYKN-GVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQD 664

  Fly   348 -------------ATNSGMHVKDIYNVPDENGQVVVNMAHPEGEETLYLAPQ----------IAK 389
                         :..|....|....|.|:..:.|.:...|..:.|..|..:          ...
  Fly   665 LRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGM 729

  Fly   390 VIKPHQIGGVRFLYDNIIESTRRYNKSSGFGCILAHSMGLGKTLQVVSFC-DIFLRHTSAKTVLC 453
            .:.|:||.|:.:|         ||:...|...|||..||||||:|.|:|. .::.........|.
  Fly   730 QLHPYQIEGINWL---------RYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLV 785

  Fly   454 VMPINTLQNWLSEFNMWIPRYSTDSNVRPRNFDIFVLNDQQKTLTARAKVILNWVHDGGVLLIGY 518
            .:|::||.||..||.:|.|.:          :.|..:.|:......|...:.  ..:|.:.  |.
  Fly   786 AVPLSTLVNWEREFELWAPDF----------YCITYIGDKDSRAVIRENELS--FEEGAIR--GS 836

  Fly   519 ELFRLLALKLVKTRKRKGSVIRPDGMDSSSDLMNLVYEALVKPGPDLVICDEGHRIKNSHAGISL 583
            ::.||      :|.:.|.:|:.     :|.:|:::....|......:::.||.||:|::.:....
  Fly   837 KVSRL------RTTQYKFNVLL-----TSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFR 890

  Fly   584 ALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCNM--FERPIQNGQCVD-STPD 645
            .|.......:::|||.||||||.|.:.:::|:      :|.:|.::  |:     |:..| |..:
  Fly   891 ILNSYTIAYKLLLTGTPLQNNLEELFHLLNFL------SRDKFNDLQAFQ-----GEFADVSKEE 944

  Fly   646 DIKLMRYRAHVLHSLLLGFVQRRSHTVLQLTLPQKYEYVILVKMTAFQRKLYDTFMT---DVVRT 707
            .:|.       ||.:|...:.||..|.:...:|.|.|:::.|:::|.|:|.|...:|   :.:.:
  Fly   945 QVKR-------LHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNS 1002

  Fly   708 K------AFPNPLKAFAVCCKIWNHPDVLYNFLKKCETDLDLEIDEEVTKGAATPIVEPSADSSL 766
            |      :..|.:.....||   |||   |.|                          |||....
  Fly  1003 KSGGGSCSLINIMMDLKKCC---NHP---YLF--------------------------PSAAEEA 1035

  Fly   767 SLASPLEKKINGSGDPINSIETFSKAENQTLFNIPASSDLNAKYLNKSPSFYDEKPEPLNYGSFG 831
            :.|:       |....|||:.
  Fly  1036 TTAA-------GGLYEINSLT-------------------------------------------- 1049

  Fly   832 SEGKNNYWMDSSILPKPGCVEVIKQTDTNMSSNFESITGSSEIVDLDTNEIKTVETTIQAPCSNN 896
                                                                             
  Fly  1050 ----------------------------------------------------------------- 1049

  Fly   897 QLDNGCNAGKPSEWNAAGSKNSSGVAAAEPFKKLLKSKQRNEEFSCSWAVDLMKNYVSGLISNSP 961
                          .|||             |.:|.||
  Fly  1050 --------------KAAG-------------KLVLLSK--------------------------- 1060

  Fly   962 KMEIFFCILKESLNLGDRILLFSQSLLTLNLLEVYLKSSYVPGSNQLWTKNSSYFRLDGSTSSQE 1026
                   :||:......|:|:|||....|::||.:|:.           :...|.|:||..:...
  Fly  1061 -------MLKQLKAQNHRVLIFSQMTKMLDILEDFLEG-----------EQYKYERIDGGITGTL 1107

  Fly  1027 RERLVNEFNA-NSNVKLFLISTRAGSLGINLTGANRVIIFDASWNPCHDTQAVYRIYRYGQTKPC 1090
            |:..::.||| .:...:||:|||||.|||||..|:.|||:|:.|||.:|.||..|.:|.||....
  Fly  1108 RQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKV 1172

  Fly  1091 FVYRIVMDRCLEKKI-------------------------YDRQ----IKKQGMSDRIVDECNPE 1126
            .:||.|....:|:::                         :.:|    |.:.|..|...::...|
  Fly  1173 MIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQELDDILRFGTEDLFKEDDKEE 1237

  Fly  1127 A-HLSMKDITNL--------------CQDY------------DSDEDTVEEVNKSTGDLSKPG-- 1162
            | |...|.:..|              ..:|            :.:|:...|:.|...:.|.|.
  Fly  1238 AIHYDDKAVAELLDRTNRGIEEKESWANEYLSSFKVASYATKEEEEEEETEIIKQDAENSDPAYW 1302

  Fly  1163 ----------SPSEEGSKPGSANMSPNASNKSNNG-----PTKPLDDQNTPKSPNGASHSPIKTE 1212
                      ...:.|...|.........|.::.|     .|:  ||.|.  ..||:.::   :|
  Fly  1303 VKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYTDGGVVAADTTR--DDSNW--QDNGSEYN---SE 1360

  Fly  1213 KNDGQEHAVHVDGIINTILDMHRHCVTKEPFMHESLLVDQKDRKLSQAEKRQ-----AHRSYELE 1272
            .:.|.:.    ||             ..:.|..::....:..|:|.:.:.|.     |.....:|
  Fly  1361 YSAGSDE----DG-------------GDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIE 1408

  Fly  1273 KKA-AVNQRFTYAPAKMNYKIVNND---GTVITKPMNQQIKTNTSSSTG---------GRSTRWI 1324
            ... ...||.::..|.|.|.:...|   ...:.:.:..:.:.|..:...         |......
  Fly  1409 VLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAET 1473

  Fly  1325 PADVWQRQGMTAQEMTLPLDVVIPTNSADKANIILKAGQRV-----------MVLKSAKGIYMQL 1378
            .||...|:|::.|.:...:.|:         ::|.|..|..           ::||..:.:...|
  Fly  1474 FADGVPREGLSRQHVLTRIGVM---------SLIRKKVQEFEHINGYYSMPELILKPCEPVRSAL 1529

  Fly  1379 --DSGKIIAIRTTAKTEPEKTNKDDVIDITDDGDTDTTKPQSPEEDVKDLTADDEPRVVKNKESN 1441
              |...:.|..|....:...|..:.|...|....:..  |.|.:.:.||..::.|    |:|.|.
  Fly  1530 KQDVAALEAPPTGGNVDKSATTSNSVTPATSAAPSPA--PASEKGEDKDKDSEKE----KDKTSA 1588

  Fly  1442 PATTSRPEMPAKDRKSTENVQHFKSQTQPNTTLA--TTTNQHQLPSDLTYSQPQQSHQQP----- 1499
            ..:..:.|..|::.|...:|:    |..|....|  |..:..::.:::..::|::..:.|
  Fly  1589 EKSEVKQEQEAEEDKKPGDVK----QENPVEEAAGDTKPSDAEVKTEVAKTEPKEETKDPEVKEE 1649

  Fly  1500 ---QQQASQQQPAQQPPPP--------------------------AYKHQNHLPAAGEGYSNANS 1535
               :::..::...::|.||                          :.|.|..:.||....:.|..
  Fly  1650 PKTEEKEKEKVDDKKPIPPTTVIDDDDDDVMIVKEDGELEKPSASSPKDQKAVAAATSAATGATG 1714

  Fly  1536 IQPNVPLPPHPGAPNSSEAPPP------ADSSYFQPKPFQHTYPPQYYDYYDNKHKSAPPGSGYH 1594
                      .||.:|.|....      ||..:.:    .||       .:.|:.|:|.||..|.
  Fly  1715 ----------KGAEDSLEVLKRKFMFNIADGGFTE----LHT-------LWLNEEKAAVPGREYE 1758

  Fly  1595 I 1595
            |
  Fly  1759 I 1759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4049	NP_611885.3	DEXHc_ARIP4	391..653	CDD:350827	67/265 (25%)
		HepA	<392..1121	CDD:440319	160/771 (21%)
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007	5/21 (24%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	16/97 (16%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	11/53 (21%)
		PLN03142	720..>1234	CDD:215601	160/785 (20%)
		DUF1087	<1292..1334	CDD:461922	5/41 (12%)
		CHDII_SANT-like	1380..1517	CDD:461920	22/145 (15%)
		CHDCT2	1757..1902	CDD:462358	2/3 (67%)